Search results for "HD"
showing 10 items of 4547 documents
Atherogenic lipoprotein phenotype and LDL size and subclasses in women with gestational diabetes.
2008
AIMS: Women with gestational diabetes are more likely to develop Type 2 diabetes and cardiovascular disease after pregnancy; however, the exact nature of the lipid alterations present is not clear. In Mediterranean women with gestational diabetes, we measured low-density lipoprotein (LDL) size and all seven subclasses, as well as the 'atherogenic-lipoprotein phenotype'[ALP, e.g. concomitant presence of elevated triglycerides, reduced high-density lipoprotein (HDL)-cholesterol and increased small, dense LDL]. METHODS: In 27 women with gestational diabetes and 23 healthy pregnant women matched for age, weeks of gestation and body mass index, we measured plasma lipids and LDL size and subclass…
Kokemus elämänhallinnasta eläkkeelle siirryttäessä ja kolmannessa iässä
2008
Suomalaisen yhteiskunnan vanheneminen ja suurten ikäluokkien siirtyminen eläkkeelle ja kolmanteen ikään nostaa esille kysymyksiä, miten vastattaisiin tulevaisuuden palvelujen tarpeisiin ja miten palvelujärjestelmää olisi kehitettävä. Tutkimuksen tarkoitus on selvittää 60- ja 65-vuotiaiden ikääntyvien elämänhallintaa ja nykyistä sekä tulevaa tuen tarvetta. Elämänhallinnan viitekehyksenä on Antonovskyn koherenssiteoria, jossa elämänhallinta rakentuu merkityksellisyydestä, hallinnantunteesta ja ymmärrettävyydestä. Aineisto koostuu 35 Helsingin Vanhan kaupungin alueella asuvan henkilön haastattelusta. Haastateltavista enemmistö oli jo eläkkeellä, mutta osa oli vielä työelämässä. Haastattelu rak…
Victims of family violence identified in emergency care : comparisons of mental health and somatic diagnoses with other victims of interpersonal viol…
2019
Family violence is a global health problem incurring significant costs to both individuals and health care systems. However, family violence as a cause of trauma and other health issues is often unidentified in patients attending emergency care. Better understanding of the risk factors associated with family violence could improve the identification and treatment of victimized patients in health care settings. Little longitudinal research exists on the mental and somatic health of family violence victims currently identified in EDs and little is known about how victims of family violence differ from other help-seeking victims of interpersonal violence. A total of 345 patients were identifie…
PhDs' early career trajectories strongly differentiated
2017
International audience
Health care and societal costs of the management of children and adolescents with attention-deficit/hyperactivity disorder in Spain : a descriptive a…
2017
Background Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition in childhood (5.3% to 7.1% worldwide prevalence), with substantial overall financial burden to children/adolescents, their families, and society. The aims of this study were to describe the clinical characteristics of children and adolescents with ADHD in Spain, estimate the associated direct/indirect costs of the disorder, and assess whether the characteristics and financial costs differed between children/adolescents adequately responding to currently available pharmacotherapies compared with children/adolescents for whom pharmacotherapies failed. Methods This was a multicenter, cross-secti…
Why do Third Sector Employees Intend to Remain or Leave their Workplace?
2016
Third sector employees have claimed to enjoy high job satisfaction and low turnover intentions because their work is considered intrinsically rewarding. Employees have strong motivation for public service and they consider the organization’s goals as their own. This makes work meaningful and thus reduces turnover intentions. Changes in the third sector institutional environment, however, have intensified the working environment. This probably undermines job quality and thus increases turnover intentions. The analysis conducted among Finnish third sector employees showed that third sector employees report more turnover intentions than their counterparts in the public or private sector. This …
Why do Young People Give up Their Job Search?
2018
The decision to search or not to search for work is usually considered a purely individual choice. However, this is a simplistic view, which ignores important structural and situational aspects of job search behaviour. This article discusses the reasons why long-term unemployed youth in Finland give up their search for work or a student place. The data comprise 28 life course interviews that were analysed by means of content analysis. The data show that young people’s job seeking behaviour is greatly influenced by how they view their labour market position and prospects. Job search abandonment is often temporary and young people soon resume their search because of the expectations of the so…
Correction to: Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit (Intensive Care…
2018
In the original publication Dr Patrick Meybohm of the Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Frankfurt University Hospital, Frankfurt, Germany was inadvertently omitted from the list of investigators.
Gut Microbiota, Microbial Metabolites and Human Physical Performance
2021
Trillions of microbes inhabiting the gut modulate the metabolism of the host. Cross-sectional studies have reported associations between physical performance and the gut microbiota (GM). Physical activity seems to increase GM diversity and the abundance of certain health-beneficial microbes. We reviewed the evidence from longitudinal studies on the connection between physically active lifestyle or long-term exercise interventions and the GM. We made literature searches using databases of Web of Science and PubMed Medline to collect human studies showing or not the associations between the GM and exercise. Many controversies exist in the studies. However, the longitudinal studies show that f…
Lipase maturation factor 1 is required for endothelial lipase activity
2011
Lipase maturation factor 1 (Lmf1) is an endoplasmic reticulum (ER) membrane protein involved in the posttranslational folding and/or assembly of lipoprotein lipase (LPL) and hepatic lipase (HL) into active enzymes. Mutations in Lmf1 are associated with diminished LPL and HL activities ("combined lipase deficiency") and result in severe hypertriglyceridemia in mice as well as in human subjects. Here, we investigate whether endothelial lipase (EL) also requires Lmf1 to attain enzymatic activity. We demonstrate that cells harboring a (cld) loss-of-function mutation in the Lmf1 gene are unable to generate active EL, but they regain this capacity after reconstitution with the Lmf1 wild type. Fur…