Search results for "HD"
showing 10 items of 4547 documents
Les sirènes mâles dans la sculpture bourguignonne
2020
J.-P. Thevenot aperçut un jour sur mon écran d’ordinateur ce curieux carreau médiéval, représentant un combat de sirènes mâles (fig. 1). Il m’en demanda des explications que je fus bien incapable de lui donner. Ce colloque réuni en son honneur me donne l’occasion de répondre à sa curiosité. Je me suis donc aventuré assez loin de mes sujets de prédilection pour pouvoir comprendre comment ces sirènes mâles - ou tritons - ont pu se retrouver sur le sol du château de Gevrey-Chambertin. Après quel...
L’habitat et la nécropole du Haut Moyen Âge du lieu-dit Le Moulin Vaquet à Honguemarre-Guenouville (Eure) : un « village prénormand » du plateau du R…
2010
Sur le plateau du Roumois, le lieu-dit Moulin Vaquet à Honguemare-Guenouville (Eure) était occupé entre le VIIe et le Xe siècle par un village, habitat rural polarisé autour d’une nécropole probablement dominée par une église de bois. La fouille de ce site par la MADE sur 8 600m2 complète celle de l’INRAP à quelques centaines de mètres. Between the 7th and 10th centuries, the “Moulin Vaquet"site, near Honguemare-Guenouville (Eure) on the Roumois Plateau, was occupied by a village – a rural settlement built around a necropolis, likely dominated by a wooden church. The 8,600m2 excavation of the site run by MADE (the Eure archaeological mission) complements the INRAP excavations a few hundred …
Aspects régionaux de l’élevage en Gaule septentrionale au second âge du Fer
2020
L’étude des restes animaux livre un certain nombre de paramètres susceptibles d’aider à la définition de groupes régionaux. Il s’agit d’abord de la morphologie des animaux, puis de données relatives à la pratique de l’élevage. L’examen auquel nous nous sommes livré montre que, pour l’instant, il reste beaucoup de problèmes à régler avant de parvenir à la définition d’éventuelles entités régionales à partir de l’étude des restes animaux. Die Untersuchung der Tierknochen liefert eine Reihe von Parametern, über die eine Definition von regionalen Gruppen möglich scheint. Es handelt sich v.a. um die Morphologie der Tiere einerseits und die Besonderheiten der Viehzucht andererseits. Unsere Unters…
The long-term transformation of the concept of CSR: towards a more comprehensive emphasis on sustainability
2021
AbstractThis article adds to the discussion of the long-term transformation of CSR, presenting a perspective on the interplay between CSR debate and public discourse on business responsibility. 50 years after Milton Friedman’s provoking claim that the only responsibility for business is to seek profit, a broader debate has emerged aligning CSR with an increasingly comprehensive concept of sustainability. We trace this evolution of the concept during the last three decades focusing on the intersection of economic, social, and environmental responsibility. Based on discourse analysis of news articles and opinion pieces in the largest public newspaper in Norway from 1990 until 2018, the study …
Estudiantes Universitarios con Trastornos del Espectro del Autismo: Revisión de sus necesidades y notas para su atención
2021
[ENIn the last 10 years we have seen an increase in the number of publications related to the inclusion in university classrooms of students with Autism Spectrum Disorders, Asperger's Syndrome or high functioning autism. This article summarizes the literature on the presence of students with Autism Spectrum Disorders at the University and reflects on the need to develop specific programs for their care within the framework of support services for students with disabilities or other similar service structures. Among the specific measures, we have found experiences on awareness programs for teachers and students with the aim of generating a culture about "autism", programs to treat anxiety, m…
Inclusive university teachers: What characterizes them and how do they think about disability
2021
espanolEl incremento de estudiantes con discapacidad en las universidades espanolas conlleva la necesidad de desarrollar practicas docentes inclusivas que garanticen la participacion y el aprendizaje de todo el alumnado. Con este trabajo se pretende: (1) conocer las concepciones que el profesorado universitario que ejerce practicas docentes inclusivas tiene sobre la discapacidad; (2) analizar las razones que les motivan para tener en cuenta las necesidades de los estudiantes con discapacidad, y (3) describir las caracteristicas que les definen. En el estudio participaron 42 docentes que fueron seleccionados como inclusivos por estudiantes con discapacidad de seis universidades publicas de d…
EU income stabilization tool: potential impacts, financial sustainability and farmer’s risk aversion
2021
AbstractThe Income Stabilization Tool, a risk management scheme introduced within the Common Agricultural Policy (CAP) 2014–2020, could help European Union farmers manage the income risks they face. This study assesses the potential impact of implementing this tool through the maximum level of contribution to the fund which determines an indifference to participate in the fund and its financial sustainability. The study relies on an expected utility approach and assesses the variability of loss ratios over time using a sample of Italian hazelnut farms as a case study. The participation depends on the level of farmers' contributions and their degree of risk aversion. However, the CAP public …
La Perdita di Funzione del Complesso di Deacetilazione Istonica Sin3A/Rpd3 Causa Fusioni Telomeriche
2008
HDAC inhibitors target oncogenic BRAF and p53 in melanoma cells and promote a switch from pro-survival autophagy to apoptosis
Antitumor effects of novel co-drugs linking histone deacetylase and ribonucleotide reductase inhibitors in hematological tumors
2011
Combination therapy is the mainstay of anticancer therapy due to the significant synergistic effects achievable. Now that anticancer drug research turned toward a more molecular targeted approach, the design of dual-target drugs appears to be a new promising strategy with the potential to improve the therapeutic efficacy of the single drug and to reduce the probability of drug induced resistance and cross resistance. In our previous work, we found that 3’-C-methyl-adenosine (3’-Me-Ado), developed by us as a potent ribonucleotide reductase (RR) inhibitor with antitumor activity against both human leukemia and carcinoma cell lines, elicited significant growth inhibitory and apoptotic synergis…