Search results for "HERA"
showing 10 items of 14928 documents
A Dual Role for Hyperbaric Oxygen in Stroke Neuroprotection: Preconditioning of the Brain and Stem Cells
2018
Stroke continues to be an extremely prevalent disease and poses a great challenge in developing safe and effective therapeutic options. Hyperbaric oxygen therapy (HBOT) has demonstrated significant pre-clinical effectiveness for the treatment of acute ischemic stroke, and limited potential in treating chronic neurological deficits. Reported benefits include reductions in oxidative stress, inflammation, neural apoptosis, and improved physiological metrics such as edema and oxygen perfusion, all of which contribute to improved functional recovery. This pre-clinical evidence has failed to translate into an effective evidence-based therapy, however, due in large part to significant inconsistenc…
DEVELOPMENT & QUALIFICATION OF BIOASSAYS FOR THE DETERMINATION OF THE BIOACTIVITY, PREDICTIVE PHARMACOKINETICS AND POTENTIAL IMMUNOGENICITY OF THERAP…
2021
The critical quality attributes of a given biotherapeutic monoclonal antibody (mAb), its molecular characterization, functional assessment and effector function analysis should be defined and profiled in detail during the life cycle of a biotherapeutic drug. In the past, this product characterization was simple and standardized. In today’s complex world of biologics, success demands a more thoughtful approach and drug developers are investing in advanced analytics much earlier in the development process. Indeed, investing in selected sophisticated and state of the art analytics in early developmental phases of a therapeutic monoclonal antibody may mitigate risks by confirming that the drug …
Profilaktyka i terapia fonoholizmu wśród uczniów szkół podstawowych
2020
Wobec nasilającego się zjawiska fonoholizmu wśród dzieci i młodzieży szczególnego znaczenia nabierają obecnie działania związane z profilaktyką i terapią tego typu zaburzeń. Istotne w nich role mają do odegrania nauczyciele, a także, co oczywiste, rodzice. Ich wysiłki jednak będą skuteczne dopiero wtedy, gdy opanują oni wiedzę dotyczącą mechanizmów powstawania omawianych patologii, zrozumieją cele i zadania, jakie się w tej kwestii przed nimi stawia, sami zaprezentują wartościowe wzorce postępowania. Materiał przytoczony w artykule (w tym wyniki badań sondażowych, przeprowadzonych w grupie rodziców uczniów szkół podstawowych) świadczy o tym, że ani jedni, ani drudzy nie do końca odpowiednio…
Patients’ conceptions of undergoing physiotherapy for persistent low back pain delivered in Finnish primary healthcare by physiotherapists who had pa…
2020
To explore the conceptions of patients with persistent low back pain (LBP) of undergoing physiotherapy delivered in Finnish primary healthcare by physiotherapists who had participated in brief training in Cognitive Functional Therapy (CFT). As part of a feasibility implementation study exploring CFT in management of LBP in the Finnish primary healthcare system, we interviewed nine patients from four geographical areas in Finland after receiving care. We used a phenomenographic approach to explore the variation in their conceptions. The analysis revealed four descriptive categories: “hung out to dry,” “stuck,” “making sense and taking control,” and “holistic approach to care and living,” tha…
Processus attentionnels et apprentissage moteur
2012
International audience; Le but de cet article est de synthétiser les travaux portant sur les effets de l’attention volontaire sur l’apprentissage d’une habileté motrice. Les premiers modèles d’apprentissage considèrent que l’apprenant franchit plusieurs étapes au cours desquelles la sollicitation des processus attentionnels diminue (Fitts & Posner, 1967). Ainsi, la réalisation d’un mouvement nécessiterait d’engager de l’attention en début d’apprentissage alors qu’elle serait automatique en fin d’apprentissage. Cet article propose de vérifier cette affirmation au regard des recherches récentes qui révèlent que l’apprenant débutant module volontairement son attention a fin d’optimiser la réal…
Krytyczne spojrzenie z perspektywy psychologa na granice poradnictwa filozoficznego w porównaniu do psychoterapii, pomocy psychologicznej i coachingu
2018
Tekst ten stanowi próbę ogólnego zdefiniowania doradztwa filozoficznego a także porównania go do profesjonalnej pomocy psychologicznej, psychoterapii i coachingu. Na początku opisana została pomoc psychologiczna z jej rodzajami i porównana do możliwych obszarów pokrewnych doradztwu filozoficznemu. Następnie opisano psychoterapię i jej poszczególne szkoły porównując je do oddziaływań doradcy filozoficznego. Na końcu opisano coaching nakreślając wspólne elementy z doradztwem udzielanym przez filozofa. Ogólne wnioski płynące z porównania tych różnych form pracy z ludźmi można określić następująco: Doradztwo filozoficzne jest dziedziną młodą w polskiej rzeczywistości. Koniecznym jest dookreślen…
The Significance of Silent Moments in Creating Words for the Not-Yet-Spoken Experiences in Threat of Divorce
2015
In the context of couple therapy involving the threat of divorce, the study examined the significance of silent moments for arriving at words for the not-yet-spoken experiences. It also examined whether interactional and embodied synchrony occurred during such silent moments. A mixed method analysis was conducted, focusing on the therapeutic dialogue, psychophysiological data (the Autonomic Nervous System, ANS), and the participants’ thoughts and feelings during individual Stimulated Recall interviews. Two episodes containing several silent moments were analyzed. The analysis indicated that during the silent moments the participants continued the therapeutic conversations through their enti…
The role of the silent moments in relational conflict situation in multi-actor therapy dialogue
2015
Tämän tutkimuksen tarkoituksena oli syventää hiljaisten hetkien merkitystä pariterapiassa keskusteltaessa parisuhdekonfliktista. Lisäksi tarkastelimme, löytyykö hiljaisten hetkien aikana synkroniaa osallistujien väliltä keskustelun ja kehon tasolla. Monimenetelmäinen tutkimuksemme keskittyi kolmeen tasoon: terapeuttiseen keskusteluun, psykofysiologisista mittareista (autonominen hermosto) saatuun informaatioon sekä osallistujien ajatuksiin ja tunteisiin SR- haastattelussa. Nämä mittarit analysoitiin ensin erikseen, jonka jälkeen niiden antama informaatio yhdistettiin. Tarkoituksena oli saada mahdollisimman luotettavaa tietoa hiljaisten hetkien merkityksestä parisuhdekonfliktin käsittelyssä.…
Long-term outcome of antiandrogen monotherapy in advanced prostate carcinoma. Twelve-year’s results of a phase II study.
2003
OBJECTIVE: To present the long-term outcome of patients with locally advanced or metastatic prostate carcinoma treated by first-line antiandrogen monotherapy. PATIENTS AND METHODS: From 1983 to 1990, 41 patients with advanced prostate carcinoma were treated with flutamide monotherapy until progression or the appearance of toxicity. Twenty-five patients (61%) had T3-T4N0M0 and 16 (39%) T2-4N0-3M1 prostate carcinoma. Consensus criteria were adopted to evaluate the response. Plasma testosterone and sexual function were recorded for the first 3 years. RESULTS: Flutamide was administered for up to 147 months; seven patients (17%) interrupted the treatment because of toxicity. There was an object…
Physical activity as a protective factor for dementia and Alzheimer’s disease: systematic review, meta-analysis and quality assessment of cohort and …
2022
ObjectivePhysical activity (PA) is associated with a decreased incidence of dementia, but much of the evidence comes from short follow-ups prone to reverse causation. This meta-analysis investigates the effect of study length on the association.DesignA systematic review and meta-analysis. Pooled effect sizes, dose–response analysis and funnel plots were used to synthesise the results.Data sourcesCINAHL (last search 19 October 2021), PsycInfo, Scopus, PubMed, Web of Science (21 October 2021) and SPORTDiscus (26 October 2021).Eligibility criteriaStudies of adults with a prospective follow-up of at least 1 year, a valid cognitive measure or cohort in mid-life at baseline and an estimate of the…