Search results for "HIF"
showing 10 items of 1515 documents
L’immagine serve il testo? L’esempio del Narrenschiff (1494) e del Fortunatus (1509)
2008
The executive functions of shifting updating and inhibition and their association with arithmetical abilities.
2008
The study aimed to investigate, in 110 children attending the fourth class of an Italian primary school, the relationships between the executive functions of shifting, updating and inhibition and various aspect of arithmetic (written calculation, arithmetical facts and numeral knowledge). Shifting was assessed rating time and errors in color/number and number/letter Making trails task. Updating was assessed using Palladino et al.’s task (2001). Inhibition of endogenous information was assessed rating intrusion errors in Updating task, whereas effortful inhibition of exogenous interference and automatic inhibition of endogenous information were respectively assessed using Stroop and Negative…
HIF-1a induces downregulated expression of Aurora A in breast cancer cell lines
2012
Background: Aurora A (AURKA) is an oncogenic serine/treonine kinase that play a critical role during mitosis, governing the correct distribution of genetic material to the daughter cells. AURKA is overexpressed in many types of human tumors including breast cancer and its deregulated expression, inducing alteration of mitotic spindle, chromosomal segregation and aneuploidy can lead to malignant transformation of cells. Aims: Since hypoxia is a typical tumoral condition which influences the expression of various proteins involved in proliferation and cell cycle progression, aim of our study was to obtain new insights into AURKA regulation in breast cancer cell lines cultured under normoxic a…
Adipose tissue in sleep apnea: effects of hypoxia and inflammation
2014
Identification and molecular characterization of a novel mutation in MSH2 gene in a lynch syndrome family
2017
Background and aim of the work: The Lynch Syndrome (LS) is associated with germline mutations in one of the MisMatch Repair (MMR) genes, including MLH1, MSH2, MSH6, PMS2, MLH3 and MSH3. The molecular characterization of mutations in these MMR genes facilitates the pre-symptomatic diagnosis of subjects at risk to develop a colon cancer or a cancer LS-related. Methods: DHPLC and direct sequencing were performed for the mutation detection analysis. Results: In this study, we identified a novel frame shift mutation, the named is c.170delT in MSH2 gene that determined a premature stop codon and consequently, the formation of a truncated protein (p. Val56Glyfs*7). This is a novel mutation, as it …
Firm demography and regional development: evidence from Italy
2017
This article contributes to the literature on firm demography and regional development in at least three different ways. First, consumption, rather than employment, which is the most common variable seen in literature, is used to measure the impact of firm demography on regional development. Second, while the literature is mainly focused on the relationship between new business formation and regional development, we investigate both entry and exit flows of firms. Third, we decompose each of these flows into spatial and sectoral components. The empirical investigation looks at the Italian regions with reference to the period 2004–2009. Results seem to be substantially divergent between the S…
Disentangling conditional effects of multiple regime shifts on Atlantic cod productivity
2020
AbstractRegime shifts are increasingly prevalent in the ecological literature. However, definitions vary, and many detection methods are subjective. Here, we employ an operationally objective means of identifying regime shifts, using a Bayesian online change-point detection algorithm able to simultaneously identify shifts in the mean and(or) variance of time series data. We detected multiple regime shifts in long-term (59-154 years) patterns of coastal Norwegian Atlantic cod (>70% decline) and putative drivers of cod productivity: North Atlantic Oscillation (NAO); sea-surface temperature; zooplankton abundance; fishing mortality (F). The consequences of an environmental or climate-relate…
The effects of using participatory working time scheduling software on working hour characteristics and wellbeing : a quasi-experimental study of irr…
2020
Background: Studies in the health care sector indicate that good work time control is associated with better perceived wellbeing but also with non-ergonomic work schedules, such as compressed work schedules. Participatory working time scheduling is a collaborative approach to scheduling shift work. Currently, there is a lack of information on whether working hour characteristics and employees' wellbeing in irregular shift work change after implementing participatory working time scheduling. Objective: To investigate the effects of using digital participatory working time scheduling software on working hour characteristics and well-being among Finnish hospital employees. Participants and met…
Verzeichniss der Rigaer See- und Fluss-Schiffe, 1908
1908
Inhalt: Verzeichniss der Rigaer See- und Fluss-Schiffe ; See-Dampfer ; Bugsir- und Fluss-Dampfer.
Verzeichniss der Rigaer See- und Fluss-Schiffe, 1909
1909
Inhalt: Verzeichniss der Rigaer See- und Fluss-Schiffe ; See-Dampfer ; Bugsir- und Fluss-Dampfer.