Search results for "HIF"
showing 10 items of 1515 documents
Growth of citrus production among the Euro-Mediterranean countries: political implications and empirical findings
2013
The agricultural matter has always played an important role in holding back the Euro-Mediterranean integration process due to the strong complementarity of the agricultures of the coastal countries which share excellent products including citrus fruits. The main goal of this paper is to understand the growth dynamics of the citriculture in the countries bordering the Mediterranean Sea. Through the application of the dynamic formulation of the Shift and Share Analysis it has been possible to analyse the trend of the amount of harvested citrus production, in physical and economic terms, in the last fifteen years, and above all which components, structural and competitive, have mainly influenc…
Fluorescent styrylpyrylium probes for the imaging of mitochondria in live cells
2021
Eight styrylpyrylium tetrafluoroborate salts have been synthesized and fully optically characterized by UV-vis absorption and fluorescence steady-state/time-resolved spectroscopies. The new dyes exhibit strong emission bands with yellow–orange colours, depending on the substituents present in the structure. Notably, the Stokes shift recorded for some of them exceeds 100 nm, a very valuable feature for biological imaging. Four of them have been assayed as biological imaging agents by confocal laser scanning microscopy (CLSM) in the human hepatoma cell line Hep3B. It has been found that all the compounds efficiently stain intracellular structures which have been identified as mitochondria thr…
Between a rock and a soft place: the role of viruses in lithification of modern microbial mats.
2021
10 pages; International audience; Stromatolites are geobiological systems formed by complex microbial communities, and fossilized stromatolites provide a record of some of the oldest life on Earth. Microbial mats are precursors of extant stromatolites; however, the mechanisms of transition from mat to stromatolite are controversial and are still not well understood. To fully recognize the profound impact that these ecosystems have had on the evolution of the biosphere requires an understanding of modern lithification mechanisms and how they relate to the geological record. We propose here viral mechanisms in carbonate precipitation, leading to stromatolite formation, whereby viruses directl…
Broadening the phenotypic spectrum and physiological insights related toEIF2S3variants
2021
Mental deficiency, epilepsy, hypogonadism, microcephaly and obesity (MEHMO) syndrome is a severe X-linked syndrome caused by pathogenic variants in EIF2S3. The gene encodes the γ subunit of the eukaryotic translation initiation factor-2, eIF2, essential for protein translation. A recurrent frameshift variant is described in severely affected patients while missense variants usually cause a moderate phenotype. We identified a novel missense variant (c.433A>G, p.(Met145Val)) in EIF2S3 in a mildly affected patient. Studies on zebrafish confirm the pathogenicity of this novel variant and three previously published missense variants. CRISPR/Cas9 knockout of eif2s3 in zebrafish embryos recapitula…
Estimating the substitutability between private and public consumption: the case of Spain, 1960–2003
2005
This paper examines the relationship between private and public consumption using Spanish data over the period 1960–2003, using a two-good permanent-income model. We extend previous analysis addressing the question of whether this relationship is stable over time, or exhibits a structural break allowing the instability to occur at an unknown point in time. Our empirical results indicated the existence of a long-run relationship between private and public consumption. We also detect a structural change of regime shift in the cointegration regression around the time of 1973–74. Finally, the estimated intratemporal and intertemporal elasticities of substitution between the two types of expendi…
FOREIGN MONOPOLIES AND TARIFF AGREEMENTS UNDER INTEGRATED MARKETS
2005
In this paper the optimal policy and the stability of a tariff agreement among the importers of a monopolized good that is sold in an integrated market are studied. To analyze the stability, the tariff agreement formation is modelled as a two-stage game. In the first stage each importer decides whether or not to sign the agreement and in the second stage the signatories and non-signatories choose their tariff whereas the monopoly chooses the quantity or the price. The findings show that the optimal policy of the importers depends on which strategic variable is selected by the monopolist but that, on the contrary, this decision has no effects on the level of cooperation that can be reached b…
EMPLOYMENT OF CATIONIC SOLID-LIPID NANOPARTICLES AS RNA CARRIERS
2007
Gene transfer represents an important advance in the treatment of both genetic and acquired diseases. In this article, the suitability of cationically modified solid-lipid nanoparticles (SLN) as a nonviral vector for gene delivery was investigated, in order to obtain stable materials able to condense RNA. Cationic SLN were produced by microemulsion using Compritol ATO 888 as matrix lipid, Pluronic F68 as tenside, and dimethyldioctadecylammonium bromide (DDAB) as cationic lipid. The resulting particles were approximately 100 nm in size and showed a highly positive surface charge (+41 mV) in water. Size and shape were further characterized by scanning electron microscopy (SEM) measurements. M…
Investigations of the emission properties of single CdS-nanocrystallites
1997
Semiconductor nanocrystallites (NCs) with a radius in the range of the bulk exciton radius exhibit a strong quantum size effect. We investigated CdS-NCs, that were spin coated on a glass cover slip, with a low temperature confocal microscope. At low coverage we could image the fluorescence light from single NCs. The typical emission spectra of single NCs show four peaks. Besides the main peak related to near bandgap recombination, up to two LO-phonon satellites and one blue shifted peak were observed. It could be shown that the absorption can be polarization dependent. From the images as well as from the intensity autocorrelation function it could be concluded that the fluorescence emission…
BEP analysis of M-ary PSK modulation schemes over double Rice fading channels with EGC
2010
In this article, the performance of M-ary phase shift keying (PSK) modulation schemes over mobile-to-mobile (M2M) fading channels with equal gain combining (EGC) in cooperative networks is analyzed. Narrowband M2M fading channels under line-of-sight (LOS) propagation conditions are modeled as double Rice processes. A dual-hop amplify-and-forward relay network, where LOS components can exist in the transmission links between the source mobile station and the destination mobile station via K mobile relays, is studied. Here, the average bit error probability (BEP) is utilized to evaluate the performance of Mary PSK modulation schemes. A simple analytical approximation for the average BEP of M-…
The emission reduction potential of electric transport modes in Finland
2021
The transportation sector has become the fastest growing source of greenhouse gas (GHG) emissions. One solution to mitigate the impacts is a shift towards electric modes. Where previous studies have only focused on the replacement of individual modes, our study presents a more holistic approach by comparing land-based, water-based and airborne transportation modes. We study the GHG emission reduction potentials of electric cars, buses, trains, ferries and aircraft in comparison to existing modes on 34 routes within Finland and across the Baltic Sea to Sweden and Estonia. By comparing the GHG emissions in carbon dioxide equivalents (CO2-eq) per passenger kilometer for each mode, we also cons…