Search results for "HIV"
showing 10 items of 1527 documents
The Downside of an Effective cART: The Immune Restoration Disease
2013
The prognosis of patients infected with human immunodeficiency virus (HIV) type 1 has dramatically improved since the advent of the highly active antiretroviral therapy (HAART), which have enabled sustained suppression of HIV replication and recovery of CD4+ T cells count [1-3]. However, many patients in resource-poor settings still start HAART at a late stage of HIV infection when they already have advanced immunodeficien‐ cy [4,5]. Immune reconstitution in HIV infected patients is characterized by replenishment of immune cells depleted directly or indirectly by HIV infection, by regeneration of primary and secondary lymphoid organs, by restoration of pathogen-specific T, B and NK cells an…
Archives et bibliothèques à Cîteaux : entreprises d'écritures au Moyen Âge (XIIe siècle - début du XVIe siècle)
2019
This thesis project deals with the organization of scriptural productions, archival and library practices of Cîteaux Abbey. We consider the multiple forms of these pratices: creation and increase of archival holdings (Abbey archives and cistercian Order documents), filing, preservation of archives, relations with users. This research takes into account the aspects of document materiality and archaeology, studying cartulary and register processes with their bindings, inventory methods of archives and manuscripts, document appraisal and disposal, classification or restoration, shelf-marks and other graphic characters.
Los ballesteros del rey, los arneses empeñados y otros nuevos documentos sobre Pero Niño
2018
RESUMENSe presentan cuatro documentos hasta ahora desconocidos sobre Pero Niño, datados entre 1404 y 1431, que arrojan luz sobre algunos episodios poco detallados o silenciados en El Victorial, la biografía caballeresca que le dedicó Gutierre Díaz de Games.PALABRAS CLAVEPero Niño, Gutierre Díaz de Games, El Victorial.ABSTRACTThis study presents four unknown documents about Pero Niño, dated between 1404 and 1431. They shed light on several episodes that are undetailed or silenced in El Victorial, the chivalric biography written by Gutierre Díaz de Games.KEYWORDSPero Niño, Gutierre Díaz de Games, El Victorial.
Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion
2006
AbstractUpon receptor-mediated activation, the gp41 hydrophobic, conserved fusion peptide inserts into the target membrane and promotes the kind of perturbations required for the progression of the HIV-cell fusion reaction. Using a synthetic combinatorial library we have identified all d-amino acid hexapeptide sequences that inhibited the fusion peptide capacity of perturbing model membranes. Two hexapeptides that effectively inhibited the fusion peptide in these systems were subsequently shown to inhibit cell–cell fusion promoted by gp41 expressed at cell surfaces. These observations might be of importance for understanding the mechanisms underlying fusion peptide activity and suggest new …
Reversibility of Central Nervous System Adverse Events in Course of Art
2022
The purpose of this study is to evaluate the frequency of central nervous system adverse events (CNS-AE) on dolutegravir (DTG) and non-DTG containing ART, and their reversibility, in the observational prospective SCOLTA cohort. Factors associated with CNS-AE were estimated using a Cox proportional-hazards model. 4939 people living with HIV (PLWH) were enrolled in DTG (n = 1179) and non-DTG (n = 3760) cohorts. Sixty-six SNC-AE leading to ART discontinuation were reported, 39/1179 (3.3%) in DTG and 27/3760 (0.7%) in non-DTG cohort. PLWH naïve to ART, with higher CD4 + T count and with psychiatric disorders were more likely to develop a CNS-AE. The risk was lower in non-DTG than DTG-cohort (aH…
Stéréophonie et littérature : résonnance et reverbération dans les chansons de gestes et romans des XIIe et XIIIe siècles
2016
The chansons de geste and chivalric romances from the 12th and 13th centuries are a faithful testimony of the reality of their time, and sensory perceptions are among these testimonies. The written word provides not only descriptive and objective information, but also the impressions perceived and conveyed by the author, which are the sensations the reader has to get acquainted with in order to make the story their own. Mentions to sound effects and the sound features of a particular space are remarkable, and a compilation of these references from various texts allows us to study the sounds, resonances, and spaces through which the sound event gains prominence in the narrative. These includ…
World Influence of Infectious Diseases from Wikipedia Network Analysis
2019
AbstractWe consider the network of 5 416 537 articles of English Wikipedia extracted in 2017. Using the recent reduced Google matrix (REGOMAX) method we construct the reduced network of 230 articles (nodes) of infectious diseases and 195 articles of world countries. This method generates the reduced directed network between all 425 nodes taking into account all direct and indirect links with pathways via the huge global network. PageRank and CheiRank algorithms are used to determine the most influential diseases with the top PageRank diseases being Tuberculosis, HIV/AIDS and Malaria. From the reduced Google matrix we determine the sensitivity of world countries to specific diseases integrat…
LOCAL STRUCTURE OF THE CuCu (EDTA) (H2O)2, 2H2O AMORPHOUS COMPLEX : A JOINT MAGNETIC, LAXS, AND MOLECULAR MECHANICS INVESTIGATION
1985
The short range order in the amorphous CuCu (EDTA) (H2O)2, 2H2O is studied by Large Angle X-ray Scattering (LAXS) and molecular mechanics. Three conformations of the complex molecule are shown to be energetically equivalent, two of which are simultaneously present in the amorphous material.
Structure of doped polyaniline - dielectric spectroscopy measurements
1993
The role of doping reagents (residual water and acid anions) in determining the electric properties of a chemically synthesized polyaniline (PANI) was studied using a dielectric spectroscopy method. Dependencies of dielectric losses and susceptibility of PANI as the functions of temperature (-100÷+100°C) and electric field frequency (0.3÷30000 Hz) were examined at it was shown the role of water acts as a doping impurity similar to acid anions. The model is proposed to explain the role of water in terms of adsorption of H 2 O molecules at nitrogen sites of PANI chain and their dissociation
Binding of Tat Protein to TAR Region of Human Immunodeficiency Virus Type 1 Blocks TAR-Mediated Activation of (2′-5′)Oligoadenylate Synthetase
1990
The TAR sequence of the 5' leader of HIV-1 long terminal repeat-directed mRNA was found to be able to bind to and to activate double-stranded RNA-dependent (2'-5')A synthetase. Binding of TAR to the purified synthetase in vitro was abolished by addition of HIV-1 Tat protein, which binds to this sequence with a high affinity. Inhibition of TAR-mediated activation of (2'-5')A synthetase by Tat was prevented in the presence of the Zn2+ and Cd2+ chelators o-phenanthroline and penicillamine, which did not impair TAR-synthetase interaction. Transient expression assays of bacterial chloramphenicol acetyltransferase (CAT) gene in HeLa cells revealed that the levels of both CAT mRNA and CAT protein …