Search results for "HIV"
showing 10 items of 1527 documents
Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs
2021
Class I SH3 domain-binding motifs generally comply with the consensus sequence [R/K]x0PxxP, the hydrophobic residue 0 being proline or leucine. We have studied the unusual 0 = Ala-specificity of SNX9 SH3 by determining its complex structure with a peptide present in eastern equine encephalitis virus (EEEV) nsP3. The structure revealed the length and composition of the n-Src loop as important factors determining specificity. We also compared the affinities of EEEV nsP3 peptide, its mutants, and cellular ligands to SNX9 SH3. These data suggest that nsP3 has evolved to minimize reduction of conformational entropy upon binding, hence acquiring stronger affinity, enabling takeover of SNX9. The R…
La portada de la iglesia de las Escuelas Pías de Gandía. Su proceso constructivo y modulación arquitectónico-musical
2020
The facade of the church of the Pious Schools of Gandia has not attracted the attention of researchers. However, its conception has a great architectural culture and constitutes an essential work to understand its context, fundamentally, that of the theoretical treatises of the Renaissance. From this study it is wanted to value its architecture and that it is considered as an outstanding ingredient to know its period of construction in general and jesuit architecture in particular. For its understanding, its interpretation in the culture of contemporary architecture treaties and, especially, in the architectural-musical theory of Leon Battista Alberti will be necessary.. La portada de la ig…
The interaction between social media, knowledge management and service quality: A decision tree analysis
2020
The existing literature fails to identify to which extent the utilization of social media could be relevant for increasing the effectiveness of knowledge management, in respect to overall business operations. In order to shed some light on this area we define three goals. Firstly, we investigate to what extent the different activities of clients on social media (SM), are important to the processes of knowledge management (KM) in companies. Secondly, we examine to what extent KM functions can be relevant in attaining the quality of IT services. Thirdly, we analyze to what extent KM mediates between SM and the quality of IT services, that is, which client activities on SM should be formalised…
Archives and documents in the digital age
2017
Este artículo se propone reflexionar sobre algunas de las características del nuevo orden digital. En particular, se centra en las mutaciones que afectan a los conceptos de archivo y documento, así como a sus rasgos más destacados. Partiendo del hecho de que estos registros son fundamentales para cualquier estudioso del pasado, indaga sobre las consecuencias de su desmaterialización. Se examina el significado de ese espacio en algunas de sus dimensiones y se subraya la evidente paradoja que supone conservar y estudiar objetos o datos que son efímeros por naturaleza y que, en su mayoría, nacieron para morir rápidamente. The paper aims to examine and explore on some of the characteristics of …
Carta de José Vidal-Beneyto a Fernando Álvarez de Miranda
2000
Historiografía de la Memoria Democrática Española
1997
Plataforma Ciudadana por la Moral Pública
2007
Long-term outcomes of oral rehabilitation with dental implants in HIV-positive patients: A retrospective case series
2016
Background: The existing information on oral rehabilitations with dental implants in VIH-positive patients is scarce and of poor quality. Moreover, no long-term follow-up studies are available. Hence, the aims of this study were to describe the long-term survival and success rates of dental implants in a group of HIV-positive patients and to identify the most common postoperative complications, including peri-implant diseases. Material and Methods: A retrospective case series of HIV-positive subjects treated with dental implants at the School of Dentistry of the University of Barcelona (Spain) was studied. Several clinical parameters were registered, including CD4 cell count, viral load and…
Intestinal tuberculosis as a cause of chronic diarrhoea among patients with human immunodeficiency virus infection: report of two cases.
2001
In Western countries human immunodeficiency virus infection is considered the main risk factor of tuberculous disease, its incidence being 500 times higher in HIV-infected patients than in the general population. Despite the disease frequently present in these patients with extraintestinal manifestations, intestinal localization is rarely observed and often as a consequence of complications such as acute gastrointestinal bleeding or perforation. The diagnosis of intestinal tuberculosis is difficult and is often delayed due to the lack of specific signs and symptoms as well as the low sensitivity of routine methods. A review of the literature is made and personal experience in the diagnosis …
Introduzione
2020
L’attualità delle riflessioni sul tema degli archivi – anche in considerazione della difficile prova alla quale in questo periodo è sottoposto l’intero sistema della didattica e della ricerca – assume particolare rilevanza se, come nel caso di questo convegno, l’alveo tematico si riferisce alla formazione degli architetti nell’Italia repubblicana. Il rimando all’analogia fra i tempi che ci aspettano e l’origine di questo percorso negli anni della Ricostruzione è inevitabile. Infat- ti, seppur la storia non si ripeta e molte sono le incognite che si prospettano oggi all’orizzonte, si può proporre un’analogia basata su quell’indispensabile impegno civile che caratterizzò la fase storica che s…