Search results for "HIV"

showing 10 items of 1527 documents

(2'-5')Oligoadenylate and intracellular immunity against retrovirus infection.

1992

1. 1. The double-stranded RNA-dependent 2′,5′-oligoadenylate (2–5A) synthetase/ribonuclease L (RNase L) system plays an essential role in the establishment of the antiviral state of a cell exposed to virus infection. 2. 2. Until recently, the application of 2–5A derivatives to reinforce this system seemed to be limited mainly due to the low specificity of RNase L for viral RNA. 3. 3. Two new strategies have been developed which yield a selective antiviral effect of 2–5As at least against human immunodeficiency virus-1 (HIV-1) infection: (i) an “intracellular immunization” appproach using 2-5A synthetase cDNA linked to HIV trans -acting response element (TAR) and (ii) inhibition of retrovira…

OligoribonucleotidesbiologyRNase P2'-5'-OligoadenylateAdenine NucleotidesHIVbiology.organism_classificationVirus ReplicationBiochemistryVirologyMolecular biologyAntiviral AgentsVirusRetrovirusBiochemistryImmunityComplementary DNAbiology.protein2'5'-Oligoadenylate SynthetaseReverse Transcriptase InhibitorsRibonuclease LIntracellularHIV Long Terminal RepeatRetroviridae InfectionsThe International journal of biochemistry
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A Prognostic Model for Estimating the Time to Virologic Failure in HIV-1 Infected Patients Undergoing a New Combination Antiretroviral Therapy Regimen

2011

Abstract Background HIV-1 genotypic susceptibility scores (GSSs) were proven to be significant prognostic factors of fixed time-point virologic outcomes after combination antiretroviral therapy (cART) switch/initiation. However, their relative-hazard for the time to virologic failure has not been thoroughly investigated, and an expert system that is able to predict how long a new cART regimen will remain effective has never been designed. Methods We analyzed patients of the Italian ARCA cohort starting a new cART from 1999 onwards either after virologic failure or as treatment-naïve. The time to virologic failure was the endpoint, from the 90th day after treatment start, defined as the firs…

OncologyMaleAdult; Anti-HIV Agents; Cohort Studies; Drug Therapy Combination; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Proportional Hazards Models; Treatment Failure; Viral LoadHIV InfectionsCohort Studies0302 clinical medicineANTIRETROVIRAL THERAPYMedicineHIV Infection030212 general & internal medicineTreatment Failure0303 health sciencesHealth PolicyMiddle AgedViral Load3. Good healthComputer Science ApplicationsCensoring (clinical trials)CohortCombinationlcsh:R858-859.7Drug Therapy CombinationFemaleViral loadHumanResearch ArticleCartAdultmedicine.medical_specialtyAnti-HIV AgentsHIV-1; antiretroviral therapyHealth InformaticsSettore MED/17 - MALATTIE INFETTIVElcsh:Computer applications to medicine. Medical informatics03 medical and health sciencesDrug TherapyInternal medicineHumansSurvival analysisProportional Hazards Models030306 microbiologybusiness.industryProportional hazards modelAdult; Anti-HIV Agents; Cohort Studies; Drug Therapy Combination; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Proportional Hazards Models; Treatment Failure; Viral Load; Health Informatics; Health PolicyANTIRETROVIRAL DRUGSAnti-HIV AgentHIVGENOTYPESDiscontinuationRegimenImmunologyProportional Hazards ModelHIV-1Cohort StudiebusinessBMC Medical Informatics and Decision Making
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A dendritic cell tumor in an HIV-infected patient: case report

2009

Oncologybusiness.industryHiv infectedImmunologyMEDLINEMedicineHematologyDendritic cellbusinessAnnals of Oncology
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Head and Neck Lymphomas in HIV Patients: a Clinical Perspective

2017

Introduction Because of the many HIV-related malignancies, the diagnosis and treatment of lymphoma in patients infected with human immunodeficiency virus are challenging. Objective Here, we review current knowledge of the pathogenesis, epidemiology, symptomatology, diagnosis, and treatment of head and neck lymphomas in HIV patients from a clinical perspective. Data Synthesis Although Hodgkin's lymphoma is not an AIDS-defining neoplasm, its prevalence is ten times higher in HIV patients than in the general population. NHL is the second most common malignancy in HIV patients, after Kaposi's sarcoma. In this group of patients, NHL is characterized by rapid progression, frequent extranodal inv…

Oncologymedicine.medical_specialtyPathologyPopulationlcsh:MedicinehivlymphomaDiseaseMalignancy03 medical and health sciences0302 clinical medicinehead and neck neoplasmsimmune system diseasesInternal medicinehemic and lymphatic diseasesEpidemiologymedicineeducationExtranodal Involvementeducation.field_of_studybusiness.industrylcsh:Rvirus diseasesHIVmedicine.diseaselcsh:Otorhinolaryngologylcsh:RF1-547LymphomaOtorhinolaryngologyOtorhinolaryngology030220 oncology & carcinogenesisSystematic ReviewDifferential diagnosisbusiness030215 immunology
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 Consistency and Proportionality in Policy Decision-Making in Blood Safety: the Case for an All-Apheresis Platelet Supply in Germany

2013

SUMMARY Recently, German investigators presented the first mathematical model finding a significant increase in the risk of HIV, HCV, and HBV transmission when pools of 4 whole-blood-derived buffy-coat platelets, rather than 1 singledonor (apheresis) component, are used to provide one platelet dose. Based, in both cases, on mathematical models employing the incidence/window-period method, the relative risk of transmission from pooled versus apheresis platelets (2.2 or 2.75 for HIV, 2.7 or 3.375 for HCV, and 3.2 or 4.0 for HBV, with pools of 4 or 5 concentrates, respectively) is similar to the difference in risk before (versus after) introduction of HIV-1 and HCV RNA screening. The absolute …

Oncologymedicine.medical_specialtybusiness.industryHuman immunodeficiency virus (HIV)Viral transmissionvirus diseasesPathogen reductionmedicine.disease_causeGeneral Biochemistry Genetics and Molecular BiologyPolicy decisionInternal medicineRelative riskImmunologymedicineBlood safetyPlateletbusinessModel findingClinical Laboratory
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Long Term Results of Stanford V Regimen and Highly Active Antiretroviral Therapy (HAART) In 59 Patients (pts) with HD and HIV Infection (HD-HIV)

2010

Abstract Abstract 4827 Background: The introduction of HAART has significantly improved the outcome of pts with HD-HIV. However there are no data on the long term follow-up of HD-HIV pts treated with conventional chemotherapy (CT) regimens. In 2002, we reported the results of a prospective phase II study with the intensive 12-week CT with adjuvant radiotherapy (Stanford V) and concomitant HAART in 59 pts (Spina et al. Blood 2002;100:1984-1988). Methods: To analyze the long term outcome of patients included in the Stanford V and HAART protocol. Results: The median follow-up is 67months (range 3–156 months The 5-yr overall survival (OS), freedom from progression (FFP), disease free survival a…

Oncologymedicine.medical_specialtybusiness.industrymedicine.medical_treatmentImmunologyHuman immunodeficiency virus (HIV)Phases of clinical researchCell BiologyHematologyStanford V regimenLong term resultschemotherapymedicine.disease_causemedicine.diseaseBiochemistrySettore MED/15 - Malattie Del SangueSurgeryStanford VIdiopathic pneumonia syndromeInternal medicineConcomitantmedicineHodgkin's diseaseFresh frozen plasmabusinessBlood
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Author Rights vs Self-Archiving in Spanish Scientific Journals

2013

AbstractThe paper analyzes publishers’ copyright policies and self-archiving conditions of Spanish scientific journals. Data are extracted from the directory DULCINEA that contains information of 1318 Spanish journals, of which 775 (61%) allow some form of self-archiving to be about 60% of the post-print version and allowing them 87% of the deposit of the version of record. In 72% of journals the deposit can be performed immediately after publication and in 16% after article acceptance. 72% of the journals are freely available without charge to the user this figure raises up to 86% if free access after an embargo is considered. Only 18% of the journals use Creative Commons licenses. The ado…

Open access publishingComputer scienceFree accessDULCINEALibrary scienceDirectoryCreative commonsOpen accessRepositoriesSelf-archivingGreen routeInstitutional repositoriesSpainLawCopyrightGeneral Materials ScienceDipòsits institucionalsDrets d'autorSelf-archivingAccés obertProcedia - Social and Behavioral Sciences
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L'archivio audiovisivo degli allestimenti verdiani

This paper focuses on the methodologies adopted for the creation of the audiovisual archive of Verdi's stagings at the Istituto Nazionale di Studi Verdiani in Parma.

Opera studies archives new mediaSettore L-ART/07 - Musicologia E Storia Della Musica
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Presence of human papillomavirus and Epstein-Barr virus in the cervix of women infected with the human immunodeficiency virus

2001

The presence of human papillomavirus (HPV) and Epstein-Barr virus (EBV) was sought in cervical scrapings from 110 human immunodeficiency virus (HIV)-infected women to evaluate the role of these viruses as risk factors for squamous intraepithelial lesions of the cervix. By using PCR, presence of HPV-DNA and EBV-DNA was found in 60.9% (67/110) and in 10% (11/110) of clinical samples, respectively. Identification of oncogenic group of HPV by hybrid capture (HC II, Murex-Digene) indicated the presence of low-risk HPV in 13 (19.4%) patients, high-risk HPV in 28 (41.8%), and both types of HPV in 26 (38.8%) patients. Squamous intraepithelial lesions were present in 59 cases, being low-grade (n = 5…

Opportunistic infectionHuman immunodeficiency virus (HIV)medicine.disease_causeVirusHerpesviridaelaw.inventionlawVirologymedicineGammaherpesvirinaeHuman papillomavirusRisk factorSidaCervixPolymerase chain reactionbiologybusiness.industryObstetrics and GynecologyGeneral Medicinebiology.organism_classificationmedicine.diseaseEpstein–Barr virusVirologyKoilocyteInfectious Diseasesmedicine.anatomical_structureViral diseasebusinessJournal of Medical Virology
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The taint of torture and the brazilian legal system

2019

In Brazil, the practice of torture intertwines deeply with its own history. The literature on the subject has had a greater intensification on its registers during the Dictatorial Regime (1964 to 1985). In spite of the Brazilian Constitution of 1988, Brazil only makes efforts to investigate the crimes of torture of this period to comply with the provisions of the United Nations in 2011. Within this scenario, the NationalTruth Commission (Law 12.528, of November 2011) was created with the purpose of clarifying the facts and circumstances of cases concerning human rights violations, as well as the Law on Access to Information (Law 12.527 of November 2011), which have regulated the constitutio…

Orden legal 37 491137-7038 8537 Arxius de sociologia 525290 2019 40 7038138 The taint of torture and the brazilian legal system De Góes BrennandEdna GusmãoTortureas well as the Law on Access to Information (Law 12.527 of November 2011)of November 2011) was created with the purpose of clarifying the facts and circumstances of cases concerning human rights violationssuch as tortureespecially because they were perpetrated by agents of the State. This article aims to present part of the research undertaken to understand the official legal procedures to prevent the practice of acts of torture in the national territory and how they are understood in the Brazilian legal systemUNESCO::SOCIOLOGÍADelamar José In Brazilwas created the Network Studies and Research on Violence-RIEV in partnership with Federal University of Paraíba-UFPB and Federal University of Santa Catarina-UFSC with the objective of investigating violations of human rights during the dictatorship1997 that criminalizes torture. ViolenceLegal orderthe practice of torture intertwines deeply with its own history. The literature on the subject has had a greater intensification on its registers during the Dictatorial Regime (1964 to 1985). In spite of the Brazilian Constitution of 1988Brazil only makes efforts to investigate the crimes of torture of this period to comply with the provisions of the United Nations in 2011. Within this scenariowhich have regulated the constitutional right to access public informationVolpato Dutrawith special attention to Law 9.455:SOCIOLOGÍA [UNESCO]the NationalTruth Commission (Law 12.528of April 7ViolenciaTorturavalid for all areas of the public administration. These laws allowed the opening of the archives of the dictatorship until denied on the basis of a severely restricted access. In this contextpersecution and violations of the right-to-live. The study of these violations is of fundamental importance for the historical unveiling of this period
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