Search results for "HLA"
showing 10 items of 664 documents
Four decades of subatomic physics : essays in honour of professor of theoretical physics Pentti Vesa Ruuskanen on the occasion of his retirement 31 D…
2006
Type 1 Diabetes and Autoimmune Thyroid Disease—The Genetic Link
2021
Type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) are the most frequent chronic autoimmune diseases worldwide. Several autoimmune endocrine and non-endocrine disorders tend to occur together. T1D and AITD often cluster in individuals and families, seen in the formation of autoimmune polyendocrinopathy (AP). The close relationship between these two diseases is largely explained by sharing a common genetic background. The HLA antigens DQ2 (DQA1*0501-DQB1*0201) and DQ8 (DQA1*0301-DQB1*0302), tightly linked with DR3 and DR4, are the major common genetic predisposition. Moreover, functional single nucleotide polymorphisms (or rare variants) of various genes, such as the cytotoxic T-lym…
Naimisen normit, käytännöt ja konfliktit : esiaviollinen ja aviollinen seksuaalisuus 1800-luvun lopun keskisuomalaisella maaseudulla
2010
Sommar'n som aldrig säger nej : om huvudteman samt metaforer i svenska och finländska Eurovisionsschlagerfestivallåter 1958-1999
1999
A search for beta-lactamase in chlamydiae, mycoplasmas, planctomycetes, and cyanelles: bacteria and bacterial descendants at different phylogenetic p…
2000
Bacteria from different phylogenetic positions such as chlamydiae, mycoplasmas, planctomycetes and also endosymbiotic murein-containing cyanelles were investigated for the production of beta-lactamases. No beta-lactamase activity was found in bacteria lacking murein such as Chlamydia pneumoniae, Mycoplasma pneumoniae, Pirellula marina and Planctomyces maris. In the murein-containing cyanelles of Cyanophora paradoxa no beta-lactamase activity could be detected.
Relationship between HLA I surface expression and different cytopathic effects produced after herpes simplex virus infection in vitro.
1992
In the present study, we investigated the effects of herpes simplex virus (HSV) infection on the expression of HLA class I antigens and beta 2-microglobulin in human fibroblasts. The mRNA abundance for HLA class I was shown to be strongly reduced after infection with HSV strains either producing cell rounding or fusion from within (FFWI), however, HLA class I expression on the surface of cells is strongly reduced only after appearance of FFWI. Using a ts mutant (ts 78R) or CyA in combination with a fusion from without (FFWO) inducing strain of HSV, this loss of HLA class I antigens is assumed to be correlated to the rearrangement of the cell membrane during the fusion process itself as a la…
Possible association of sudden infant death with partial complement C4 deficiency revealed by post-mortem DNA typing of HLA class II and III genes
1989
Based on evidence of an increased rate of respiratory infections in sudden infant death (SID) infants as well as the observation of familial occurrence, we analysed in a retrospective study class II and class II genes of the major histocompatibility complex in 40 cases of SID by Southern blot analysis of DNA obtained post mortem from tissue samples. In 24 cases, the parents were interviewed and confirmatory human lymphocyte antigen (HLA) and DNA typing was carried out. Using HLA-DR beta and -DQ beta probes, no evidence of an abnormal HLA-DR frequency distribution in SID infants was detected (P = 0.97). Using DNA probes for the tandemly arranged complement C4 and steroid 21-hydroxylase genes…
Complete phylogeny and historical biogeography of true rosefinches (Aves:Carpodacus)
2013
True rosefinches (Aves: Carpodacus) are restricted to Eurasia, and 19 out of 25 species occur in the Sino-Himalayas, making this the likely centre of origin. To test this hypothesis, suggested species splits had to be evaluated and potential further cryptic diversity unravelled. A taxon-complete dated molecular phylogeny was reconstructed using maximum-likelihood and Bayesian methods. Maximum-parsimony and likelihood approaches were applied to deduce ancestral areas. Rosefinches, including the widespread Carpodacus erythrinus (Pallas, 1770), originated in south-west China (and the Himalayas) 14 Mya, and gave rise to a smaller clade consisting of C. erythrinus, Haematospiza sipahi (Hodgson, …
Fuch's heterochromic cyclitis and HLA histocompatibility antigens
1994
Genetic typing of class I major histocompatibility complex (MHC) antigens (HLA-A, -B and -C) was performed in 22 patients with Fuch's heterochromic cyclitis (FHC) and in a control group of 339 healthy subjects in order to ascertain whether there are any genetic factors that protect against or increase the risk of developing this disease. The frequency of only one HLA-antigen was found to differ significantly in the patients with FHC as compared with the normal subjects: HLA-A2 had a negative association with FHC (9.09% in FHC versus 47.47% in the control group; p<0.01, Fisher's exact test with correction for the number of antigens studied) with an odds ratio of 0.11 (95% confidence limits 0…