6533b853fe1ef96bd12acda7
RESEARCH PRODUCT
Relationship between HLA I surface expression and different cytopathic effects produced after herpes simplex virus infection in vitro.
Dietrich FalkeJ. KunkelK. WeiseW. SchwaebleIwan Walevsubject
biologyCellGene ExpressionGenes MHC Class IGeneral MedicineHuman leukocyte antigenbiology.organism_classificationmedicine.disease_causeBlotting NorthernVirologyHerpesviridaeVirusIn vitroHerpes simplex virusmedicine.anatomical_structureAntigenCytopathogenic Effect ViralHLA AntigensVirologyAlphaherpesvirinaemedicineHumansSimplexvirusbeta 2-MicroglobulinCells Cultureddescription
In the present study, we investigated the effects of herpes simplex virus (HSV) infection on the expression of HLA class I antigens and beta 2-microglobulin in human fibroblasts. The mRNA abundance for HLA class I was shown to be strongly reduced after infection with HSV strains either producing cell rounding or fusion from within (FFWI), however, HLA class I expression on the surface of cells is strongly reduced only after appearance of FFWI. Using a ts mutant (ts 78R) or CyA in combination with a fusion from without (FFWO) inducing strain of HSV, this loss of HLA class I antigens is assumed to be correlated to the rearrangement of the cell membrane during the fusion process itself as a late event of cytopathogenicity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-03-01 | Archives of virology |