Search results for "HOF"

Evoked responses to transcranial and electrical stimulation during isometric and lengthening contractions of the soleus muscle

2011

The aim of this study was to assess differences in motor control between isometric and lengthening contractions of the soleus muscle. Evoked responses to TMS (MEPs) and electrical stimulation of the peripheral nerve (H-reflexes) where recorded at rest and during isometric and lengthening contractions of the soleus muscle at 20%, 40%, 60% and 80% MVC. Torque and background EMG were averaged over a time window of 100ms prior to stimulation. MEPs were found to be significantly lower (P < 0.05) during lengthening contractions compared to isometric contractions at 40%, 60% and 80% MVC (10.95 ± 0.05 mV vs 9.93 ±0.06 mV ; 1.47 ± 0.07 mV vs 9.7 ± 0.08 mV; 11.48 ± 0.08 mV ± vs 10.14 ± 0.07 mV). The …

Exploring gender roles in Finnish and American youth : a critical review of Geert Hofstede's masculinity versus femininity dimension of national cult…

2004

A case of combined Farber and Sandhoff disease

1989

We describe a patient with the biochemically established combination of Farber and Sandhoff disease. A 6-month-old girl of consanguineous Turkish parents presented with hoarseness, stridor, scattered skin nodules, painful swelling of hand joints and ankles, and cherry-red macular spots. Until the age of 2 years her motor and physical condition deteriorated distinctly, however her mental state remained unchanged. A biopsied skin nodule disclosed lysosomal inclusions within storage cells that were typical of Farber disease (curved tubular structures). However, other inclusions (e.g. zebra bodies) were also found. Biochemical findings included ceramide accumulation in skin nodules and cultured…

Different modes of activating phosphofructokinase, a key regulatory enzyme of glycolysis, in working vertebrate muscle

2002

Glycolytic flux in white muscle can be increased several-hundredfold by exercise. Phosphofructokinase (PFK; EC 2.7.1.11) is a key, regulatory enzyme of glycolysis, but how its activity in muscle is controlled is not fully, understood. In order not to neglect integrative aspects of metabolic regulation, we have studied in frogs (Rana temporaria) a physiological form of muscle work (swimming) that can be triggered like a reflex. We analysed swimming to fatigue in well rested frogs, recovery from exercise, and repeated exercise after 2 h of recovery. At various times, gastrocnemius muscles were tested for glycolytic intermediates and effectors of PFK. All metabolites responded similarly to the…

Fructose 2,6-bisphosphate and glycolytic flux in skeletal muscle of swimming frog

1990

AbstractGlycolytic flux in skeletal muscle is controlled by 6-phosphofructokinase but how this is achieved is controversial. Brief exercise (swimming) in frogs caused a dramatic increase in the phosphofructokinase activator, fructose 2,6-bisphosphate, in working muscle. The kinetics of phosphofructokinase suggest that in resting muscle, the enzyme is inhibited by ATP plus citrate and that the increase in fructose 2,6-bisphosphate is part of the mechanism to activate phosphofructokinase when exercise begins. When exercise was sustained, fructose 2,6-bisphosphate in muscle was decreased as was the rate of lactate accumulation. Glycolytic flux and the content of fructose 2,6-bisphosphate appea…

The HIF1α-PFKFB3 Pathway: A Key Player in Diabetic Retinopathy

2021

Abstract Diabetic retinopathy (DR) is the leading cause of blindness for adults in developed countries. Both microvasculopathy and neurodegeneration are implicated in mechanisms of DR development, with neuronal impairment preceding microvascular abnormalities, which is often underappreciated in the clinic. Most current therapeutic strategies, including anti-vascular endothelial growth factor (anti-VEGF)-antibodies, aim at treating the advanced stages (diabetic macular edema and proliferative diabetic retinopathy) and fail to target the neuronal deterioration. Hence, new therapeutic approach(es) intended to address both vascular and neuronal impairment are urgently needed. The hypoxia-induci…

Hoffa’s fat pad thickness: a measurement method with sagittal MRI sequences

2021

Abstract Background Hoffa’s fat pad is a structure located within the fibrous joint capsule of the knee joint, but outside the synovial cavity. It plays an important biomechanical and metabolic role in knee joint, reducing the impact of forces generated by loading and producing cytokines. Changes in its size can induce modifications in the knee homeostasis. However, a great variability exists regarding its measurements. This work aims to evaluate the reliability of a measurement method of Hoffa’s fat pad dimensions through MRI. Methods 3T sagittal IW 2D TSE fat-suppressed MRI sequences, taken from the OAI (Osteoarthritis initiative) database, of 191 male and female patients, aged between 40…

Preoperativ oppvarming av pasienter med hoftebrudd : Kan preoperativ oppvarming med varmluftsteppe redusere intraoperativt temperaturfall hos pasient…

2018

Masteroppgave spesialsykepleie ME519 – Universitetet i Agder 2018 Background: Hip fractures are a common cause of hospitalization and are linked with high morbidity and mortality rates. It is therefore important to optimize every aspect of their treatment to minimize complications. The Nurse Anesthetist plays an important role in preventing complications related to both surgery and anesthesia. Purpose: The aim of this project is to evaluate the quality of the current procedure for preoperative prevention of hypothermia in our hospital. We wanted to investigate if this procedure for preventing hypothermia is as effective as preoperative warming with a forcedair system in hip fracture patient…

The existence of solutions for the modified (p(x), q(x))-Kirchhoff equation

2022

We consider the Dirichlet problem-Delta(Kp)(p(x))u(x) - Delta(Kq)(q(x))u(x) = f(x, u(x), del u(x)) in Omega, u vertical bar(partial derivative Omega) = 0,driven by the sum of a p(x)-Laplacian operator and of a q(x)-Laplacian operator, both of them weighted by indefinite (sign-changing) Kirchhoff type terms. We establish the existence of weak solution and strong generalized solution, using topological tools (properties of Galerkin basis and of Nemitsky map). In the particular case of a positive Kirchhoff term, we obtain the existence of weak solution (= strong generalized solution), using the properties of pseudomonotone operators.

Fizisko un psihofizioloģisko parametru sakarības 11-16 gadus veciem skolēniem ar viegliem garīgās attīstības traucējumiem

2022

Skolēna fiziskā, psihiskā un intelektuālā attīstība ir savstarpēji saistītas. Lai labāk veicinātu skolēnu ar viegliem garīgās attīstības traucējumiem personības attīstību ir nepieciešams zināt sakarības starp organisma fiziskajiem un psihofizioloģiskajiem parametriem. Mērķis ir novērtēt 11-16 gadus vecu pusaudžu ar viegliem garīgās attīstības traucējumiem kustību un psihofizioloģiskās spējas, un izpētīt fizisko un psihofizioloģisko spēju kopsakarības. Mērķa sasniegšanai tika izvirzīti šādi uzdevumi: 1.veikt zinātniskās literatūras izpēti un analīzi atbilstoši diplomdarba tematam; 2. novērtēt skolēnu ar viegliem garīgās attīstības traucējumiem fiziskās spējas; 3.novērtēt skolēnu ar viegliem …