Search results for "HOMA"
showing 10 items of 956 documents
FRI0194 Is There an Association Between Spondyloarthritis and Antibodies Towards Borrelia, Ehrlichia and Chlamydia Species?
2015
Background Several studies suggested that certain microorganisms might contribute to initiation and perpetuation of spondyloarthritis (SpA). Objectives To investigate IgG and IgM antibodies towards Borrelia burgdorferi (Bb), Borrelia garinii (Bg), Borrelia afzelii (Ba), Ehrlichia spp. (Ehr), Chlamydia trachomatis (Ct), and Chlamydia pneumoniae (Cp) in SpA patients, low back pain patients, and healthy subjects and to elucidate whether previous infections could play a role in the onset of SpA. Methods Data collection was based on persons aged 18-40 years referred with low back pain for ≥3 months. They were examined with MRI of the spine and sacroiliac joints, CRP, HLA-B27, and clinical SpA fe…
MINIMIZING INFLIXIMAB TOXICITY IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE
2008
Abstract Background Infliximab is a widely used biological agent for the treatment of inflammatory bowel disease, and has a favorable risk/benefit ratio. Aim It is useful to know that patients treated with infliximab are exposed to developing adverse events that could be reduced with a prudent and a rational clinical approach and by optimizing the treatment protocol. Methods PubMed (including Epub) was searched in October 2006 and again in March 2007. Results The high immunogenic potential of infliximab determines the antibodies that inhibit the effect of infliximab and the appearance of subsequent acute and delayed infusion reactions. Infliximab has an immunomodulatory effect, thus increas…
Revision of New World Species of the Shore-fly Subgenus Allotrichoma Becker of the Genus Allotrichoma with Description of the Subgenus Neotrichoma (D…
2012
The New World species of the subgenera Allotrichoma Becker and Neotrichoma (new subgenus) are revised, including a phylogenetic analysis of the species groups and subgenera within the genus Allotrichoma. For phylogenetic perspective and to document the monophyly of the genus Allotrichoma and its included subgenera and species groups, we also provide a cladistic analysis of genera within the tribe Hecamedini. The ingroup included seven exemplar congeners from within Allotrichoma. Outgroup sampling included exemplars of other genera within Hecamedini and from the putative sister group, Lipochaetini, and to root the analysis, we used an exemplar of the tribe Discocerinini. Analyses with succes…
B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma
2023
Primary Sjogren syndrome (pSS) is the second most common autoimmune disorder worldwide, which, in the worst scenario, progresses to Non-Hodgkin Lymphoma (NHL). Despite extensive studies, there is still a lack of knowledge about developing pSS for NHL. This study focused on cells’ signaling in pSS progression to the NHL type of diffuse large B-cell lymphoma (DLBCL). Using bulk RNA and single cell analysis, we found five novel pathologic-independent clusters in DLBCL based on cells’ signaling. B-cell receptor (BCR) signaling was identified as the only enriched signal in DLBCL and pSS peripheral naive B-cells or salivary gland-infiltrated cells. The evaluation of the genes in association with …
Funktionaalisia a posteriori virhearvioita Uzawan tyyppisille menetelmille kokoonpuristumattomien virtausten tapauksessa
2012
Stokesin yhtälöllä voidaan kuvata nesteiden ja kaasujen liikettä, jos liike on yksiulotteista tai hidasta. Stokesin yhtälö on yksinkertaistettu ja linearisoitu versio Navier-Stokesin yhtälöistä. Tässä tutkielmassa keskitytään kokoonpuristumattomiin ja viskoottisiin nesteisiin ja kaasuihin. Kokoonpuristumattomuus tarkoittaa sitä, että nesteen tai kaasun tiheys ei muutu ajan suhteen. Viskoottisuus taas tarkoittaa sitä, että nesteillä ja kaasuilla on sisäistä kitkaa, joka muodostuu, kun aineen osaset liikkuvat toistensa suhteen. Vaikka osittaisdifferentiaaliyhtälöiden tutkimus on edennyt viime vuosisadalla hyvinkin nopeasti, on analyyttisen ratkaisun löytäminen vaikeaa tai lähes poikkeuksetta …
Necesario, pero no deseado. Las advertencias de Thomas Hobbes sobre los peligros de la multitud, el populismo y la democracia
2016
The purpose of this article is to analyse Hobbes’s understanding of democracy. The first part of the article analyses the role of democracy in the social contract. It aims to show how there exists a democratic element at the beginning of the process of social contract, in which the multitude is transformed into a people. However, after the first social contract is made, Hobbes aims to reduce the power of the people by leading the process of social contract on to another level, on which the power of the people is assigned to a representative of the sovereign power, for example a monarch. The second part of the article aims to explain the practical reasons, provided by Hobbes in different par…
Federaliści i rozłam między klasycznością a modernością
2014
The article shows how the classical political thinking, based on civic virtues, and modernist thinking, based on individualism and self-interest, formed the basis of the U.S. Constitution. The Founding Fathers did not realize the full extent of the rift between classicism and modernity. When, as a result of intellectual discussions and practice of social life, this divide began to become more and more obvious, there has been a transition from the classical to the modernist paradigm in American politics. However, the dispute between classicism and modernity still continues and takes on new forms. On the one hand, contemporary political thinking is seen as a triumph of modernism, in which the…
O duchowym przywództwie politycznym. Polityka duchowa jako droga dla rozwoju przyszłej Europy
2022
Duchowe przywództwo polityczne odnosi się do sztuki rządzenia państwem, która uwzględnia pełny i wszechstronny rozwój osobowy człowieka, umożliwia obywatelom samorealizację i w ten sposób zaspakaja ludzkie dążenie do osiągnięcia doskonałości moralnej i intelektualnej, osiągającej swój najwyższy stopień rozwoju w świętości jako łączności z doskonałością Boga. Jego celem jest szczęśliwe społeczeństwo, w którym każdy ma możliwość samorealizacji, a jednocześnie szanuje samorealizację innych. Wspiera harmonię społeczną, która wynika ze współdziałania między różnymi grupami w obrębie społeczeństwa oraz jest alternatywą dla dzisiejszej dysharmonii będącej pokłosiem toczącego się konfliktu politycz…
Mitä filosofi tekee psykiatrisella klinikalla, Thomas Fuchs?
2019
Saksassa Heidelbergin yliopistoklinikalla on pitkät perinteet filosofian ja psykiatrian yhteistyölle. Fenomenologisen psykiatrian ja psykoterapian tutkimusyksikköä johtava professori Thomas Fuchs kertoo, miten fenomenologista tutkimusta tehdään psykiatrisessa sairaalassa ja kuinka hänen omat filosofiset sitoumuksensa tulevat esille potilastyössä. Keskustelumme klinikalla valotti hänen ajattelunsa pääpiirteitä kehollisuudesta, tunteiden filosofiasta ja tiedostamattomasta. Fuchs käsittää tunteet vuorovaikutteisina, ruumiillisina ja tilallisina ilmiöinä ja väittää, ettei tiedostamaton sijaitse psyyken syvyyksissä vaan on kehollisesti eletty ja koettu. nonPeerReviewed
Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth
2010
Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases. However, the molecular mechanisms through which NGF regulates cytoskeletal changes and neurite outgrowth are not totally understood. In this work, we identify the Rac1-specific guanine exchange factor (GEF) Tiam1 as a novel mediator of NGF/TrkA-dependent neurite elongation. In particular, we report that knockdown of Tiam1 causes a significant reduction in Rac1 activity and neurite outgrowth induced by NGF. Physical interaction between Tiam1 and active Ras (Ras- GTP), but not tyrosine phosphorylation of Tiam1, plays a central role in Rac1 activation by NGF. In add…