Search results for "HP"
showing 10 items of 1505 documents
Enable concurrent transmissions with beamforming for broadband wireless access in CSMA/CA-based WLANs
2014
In CSMA/CA based wireless local networks, two stations are not allowed to transmit at the same time due to interference generated to each other, resulting in degraded throughput. Concurrent transmission, which enables simultaneous transmission of two or more stations under certain conditions, is able to overcome this problem, leading to enhanced channel utilization efficiency. Different from earlier work on this topic which focuses on omni-direction concurrent transmission, we introduce in this paper beamforming into a co-channel concurrent transmission scheme and investigate the benefits of concurrency with beamforming. The circumstances for concurrent transmission and frame scheduling are…
Activated Biochar From Posidonia Oceanica. A New Adsorbent Material of Hydrocarbons from Wastewater
2019
Environmental pollution by petroleum derivatives is a very current topic. In particular, low concentration of this kind of pollutants can seriously compromise the life of animals and plants of aquatic ecosystems (Yu, 2017). The current legislation provides that bilgewater, wastewater produced by boats, can be discharged directly into the sea only if the total hydrocarbon concentration not exceds 15 mg L-1. In this work, new activated carbons were tested as adsorbent materials of oil / hydrocarbons from wastewater. Moreover, an instrumental technique able to quickly measure the required low hydrocarbons concentration is also proposed. The new activated carbons were obtained from bio-oil prod…
Modeling a Novel Variant of Glycogenosis IXa Using a Clonal Inducible Reprogramming System to Generate "Diseased" Hepatocytes for Accurate Diagnosis.
2022
The diagnosis of inherited metabolic disorders is a long and tedious process. The matching of clinical data with a genomic variant in a specific metabolic pathway is an essential step, but the link between a genome and the clinical data is normally difficult, primarily for new missense variants or alterations in intron sequences. Notwithstanding, elucidation of the pathogenicity of a specific variant might be critical for an accurate diagnosis. In this study, we described a novel intronic variant c.2597 + 5G > T in the donor splice sequence of the PHKA2 gene. To investigate PHKA2 mRNA splicing, as well as the functional consequences on glycogen metabolism, we generated hepatocyte-like ce…
High-throughput elucidation of thrombus formation reveals sources of platelet function variability
2019
In combination with microspotting, whole-blood microfluidics can provide high-throughput information on multiple platelet functions in thrombus formation. Based on assessment of the inter-and intra-subject variability in parameters of microspot-based thrombus formation, we aimed to determine the platelet factors contributing to this variation. Blood samples from 94 genotyped healthy subjects were analyzed for conventional platelet phenotyping: i.e. hematologic parameters, platelet glycoprotein (GP) expression levels and activation markers (24 parameters). Furthermore, platelets were activated by ADP, CRP-XL or TRAP. Parallel samples were investigated for whole-blood thrombus formation (6 mi…
Prevalence of older in-patients at risk of clopidogrel resistance according to the STIB score. Results from REPOSI registry
2017
The phenomenon of resistance to copidogrel catches the attention of a growing number of clinicians because of its frequency and the severity of adverse events related to it. The identification of patients with high platelet reactivity (HPR may help to improve their therapy applying the concept of personalized medicine, most important in the older people treated with polypharmacy. The existece of such a simple clinical method as the STIB score, that allows to predict the possible resistace to clopidogrel at the bedside without using expensive laboratory investigations, provides an attractive approach to the problem.
On the design of pervasive computing applications based on Bluetooth and a P2P concept
2006
As an example of implementing the pervasive computing, we developed an application framework to deploy an easy, spontaneous, and infrastructureless network. We selected the Bluetooth technology with the peer-to-peer (P2P) concept to develop an experimental application which enables peers to exchange their resources. Overall network architecture and the prototype application are presented. We selected a small test-bed and simulation to evaluate the overall performance and system behaviour. We measured and present our findings in term of the duration of inquiry procedure and the throughput, according to various experimental parameters such as physical distance between nodes and their speeds.
Index-based triangulation method for efficient generation of large three-dimensional ultrasonic C-scans
2018
The demand for high-speed ultrasonic scanning of large and complex components is driven by a desire to reduce production bottlenecks during the non-destructive evaluation (NDE) of critical parts. Emerging systems (including robotic inspection) allow for the collection of large volumes of data in short time spans, compared to existing inspection systems. To maximise throughput, it is crucial that the reconstructed inspection datasets are generated and evaluated rapidly without loss of detail. This requires new data visualisation and analysis tools capable of mapping complex geometries while guaranteeing full coverage. This paper presents an entirely new approach for the visualisation of thre…
A Definitive Pharmacophore Modelling Study on CDK2 ATP Pocket Binders: Tracing the Path of New Virtual High-Throughput Screenings
2020
Cyclin Dependent Kinases-2 (CDK2) are members of serine/threonine protein kinases family. They play an important role in the regulation events of the eukaryotic cell division cycle, especially during the G1 to S phase transition. Experimental evidence indicate that excessive expression of CDK2s should cause abnormal cell cycle regulation. Therefore, since a long time, CDK2s have been considered potential therapeutic targets for cancer therapy. In this work, onehundred and forty-nine complexes of inhibitors bound in the CDK2-ATP pocket were submitted to short MD simulations (10ns) and free energy calculation. Comparison with experimental data (K<sub>i</sub>, K<sub>d</su…
A novel prototype to closely mimic mastication for in vitro dynamic measurements of flavour release
2005
International audience; Flavour release during eating of a food depends upon many parameters that can hardly be managed. In-vivo measurements by the APCI MS-nose method allowed temporal sensory evaluation and flavour release data to be directly correlated, but several limitations have frequently been reported. These were: high inter-individual variability, low repeatability of measurements, and weak experiment throughput due to panellists' exhaustion. To overcome most of these limitations, the use of an artificial mouth for online mesurement of flavour release is recommended. However, the systems used in previous reports were limited in terms of reproducing in-vivo oral functions and parame…
ENERGY RECOVERY FROM REGASIFICATION OF LNG
2012
The international forecasts on energy consumption in the next future show an increasing trend due also to growing markets, and among this the leading emerging economies connected to BRICS countries (Brazil, Russia, India, China and South Africa). We need more and more energy. On the other side the environmental problem is arising and the climate change is a more and more pressing emergency. The latest environmental disasters, as the oil spill in the Gulf of Mexico in 2010 and the earthquake with the following tsunami in Japan in 2011, struck the public opinion and so, as in many European countries, the nuclear program is under a deep revision or even stopped. So it is necessary to utilize a…