Search results for "HRAS"
showing 10 items of 293 documents
Un intellectuel exilé dans la tourmente du Risorgimento : Antonio Ronna, lexicographe et professeur
2016
Il lessicografo e professore Antonio Ronna (1801-1866) appartiene a quella schiera di intellettuali impegnati che presero parte al Risorgimento e che si esiliarono per non piegarsi al giogo del regime austriaco. Nel 1836, completa, grazie alle schede lasciate da Biagioli, il Dictionnaire italien-français, français-italien: è l'inizio di un'attività che ne farà uno dei lessicografi di maggior successo dell'Ottocento. Lo stesso anno, a seguito di una revisione piuttosto sommaria, pubblica anche una ripresa del Dizionario di Barberi; occorrerà attendere il 1858 affinché il suo proprio dizionario, ispirato a quello di Biagioli, venga pubblicato. All'attività di lessicografo, Ronna unisce quella…
O pewnej możliwości ewaluacji frazeologii na przykładzie danych z portalu Грамота.ру i z Narodowego Korpusu Języka Rosyjskiego
2020
The author of the article has run an experiment based on extracting a portion of phraseology from an online Russian language dictionary for further corpus-driven study. On the basis of the list of 100 most common Russian nouns the author has constructed queries to the Грамота.ру web portal that led to extracting over 600 idioms. These were subsequently used to perform another search in the Russian National Corpus. The main goal of this article is to construct a small dictionary of phraseological units extracted from Грамота.ру, as well as discuss the problem of evaluation of phraseology with the use of corpus-extracted data. The author argues that this kind of aproach can provide a consider…
Mutant HRAS as novel target for MEK and mTOR inhibitors.
2015
HRAS is a frequently mutated oncogene in cancer. However, mutant HRAS as drug target has not been investigated so far. Here, we show that mutant HRAS hyperactivates the RAS and the mTOR pathway in various cancer cell lines including lung, bladder and esophageal cancer. HRAS mutation sensitized toward growth inhibition by the MEK inhibitors AZD6244, MEK162 and PD0325901. Further, we found that MEK inhibitors induce apoptosis in mutant HRAS cell lines but not in cell lines lacking RAS mutations. In addition, knockdown of HRAS by siRNA blocked cell growth in mutant HRAS cell lines. Inhibition of the PI3K pathway alone or in combination with MEK inhibitors did not alter signaling nor had an imp…
Crossing Phrase Boundaries In Music
2018
This paper presents a new model for segmenting symbolic music data into phrases. It is based on the idea that melodic phrases tend to consist of notes, which increase rather than decrease in length towards the phrase end. Previous research implies that the timing of note events might be a stronger predictor of both theoretical and perceived segmentation than pitch information. Our approach therefore relies only on temporal information about note onsets. Phrase boundaries are predicted at those points in a melody where the difference between subsequent note-to-note intervals reaches minimal values. On its own, the proposed model is parameter-free, does not require adjustments to fit a partic…
Terminoloģijas lietojums mobilo iekārtu lietošanas instrukcijās
2018
Maģistra darbā pētīts terminoloģijas lietojums mobilo iekārtu lietošanas instrukcijās. Darba mērķis ir izpētīt vienotas terminoloģijas pieejamību tehniskās nozares terminoloģijai, kura izmantota mobilo iekārtu lietošanas pamācībās. Pētījumā izmantotās metodes ir teorētisko materiālu (grāmatu un publikāciju) apskats un izmantotās terminoloģijas un tās tulkojumu analīze. Pētījuma rezultāti liecina, ka lielākajai daļai no atlasītajiem terminiem nav pieejams vienots tulkojums, vai termins darināts latviešu valodā, kas secīgi noved pie situācijas, kurā tulkotājs kļūst par valodnieku, kuram jādarina terminoloģiskās frāzes.
O funkcji substytucji frazemów w reklamie prasowej
2022
Substytucja jest metodą modyfikacji formalnej frazemu, która ze względu na swoje walory komunikacyjne i ekspresywny charakter jest jednym z ulubionych środków językowych w reklamach prasowych. Jej popularność można wyjaśnić m.in. niewyczerpanymi możliwościami wyrazistych gier językowych o różnych stopniach trudności w odbiorze. Celem artykułu jest nie tylko prezentacja substytucji jako metody formalnej modyfikacji frazemu wywołującej efekty semantyczne, ale przede wszystkim omówienie jej funkcji w reklamie prasowej. Substytucja dzięki swojej kreatywności skupia uwagę odbiorcy, zachęca do lektury oraz wzmacnia koherencję tekstu ogłoszenia prasowego. Dzięki znajomości utartego sformułowania u…
La fonction expressive
2010
La discussion théorique, visant à circonscrire avec plus de netteté le concept cible, est présente non seulement dans l'articule d'ouverture qui revient sur la conception guillaumienne de l'expressivité, mais aussi dans l'ensemble des autres articles qui s'attachent à donner une (des) définition(s) opératoire(s) de la notion, permettant, d'une part, de tracer une ligne de partage entre elle et les notions proches, et d'autre part de fournir une base méthodologique sûre lorsqu'il s'agit d'analyser des phénomènes langagiers touchant à des niveaux aussi divers que la morphologie lexicale, le lexique ou l'analyse du discours. Les études de cas portent sur cinq langues indo-européennes (anglais,…
A Comparative Analysis of Piotr Borkowski's (1963) and Roman Gajda's (1970) English–Polish Phraseological Dictionaries: Practice vs. Theory
2022
This paper offers an insight into the short and largely unexplored history of English–Polish and Polish–English phraseological lexicography. It aims to analyse two post-war English–Polish phraseological dictionaries, An English–Polish Dictionary of Idioms and Phrases (1963) by Piotr Borkowski and Wybór idiomów angielskich [A Selection of English Idioms] (1970) by Roman Gajda, from a qualitative and quantitative perspective. At first sight, they seem to share several features, insofar as both are monoscopal English–Polish volumes of a similar size; both were addressed to Polish learners of English; and both drew on The Kosciuszko Foundation Dictionary: English–Polish (1959), an exhaustive re…
Das sprachliche Bild von Trägern ausgewählter Berufsbezeichnungen in der deutschen Phraseologie und Parömiologie
2018
The subject of the analysis of this article are the word combinations which in their composition include a component in the form o f the name of selected professions and those which occur in available German dictionaries. The aim of the article is to reconstruct the linguistic image established in them and to compare whether the analysed phraseologies and proverbs are also used in the contemporary language and whether the former linguistic image of the analysed professions has perhaps changed.
Distinctive Lexical Patterns in Russian Patient Information Leaflets: A Corpus-Driven Study
2019
This methodologically-oriented corpus-driven study focuses on distinctive patterns of language use in a specialized text type, namely Russian patient information leaflets. The study’s main goal is to identify keywords and recurrent sequences of words that account for the leaflets’ formulaicity, and - as a secondary goal - to describe their discoursal functions. The keywords were identified using three methods (G2, Hedges’ g and Neozeta) and the overlap between the three metrics was explored. The overlapping keywords were qualitatively analyzed in terms of discoursal functions. As for the distinctive multi-word patterns, we focused on recurrent n-grams with the largest coverage in the corpus…