Search results for "HSPA"

Cloning and characterization of CSP37, a novel gene encoding a putative membrane protein of Candida albicans.

1997

In the course of an analysis of the functions and assembly of the cell wall of Candida albicans, we have cloned and characterized a gene, which we designated CSP37 (cell surface protein), encoding a 37-kDa polypeptide which is a membrane-associated protein. The gene was isolated by immunological screening of a DNA library constructed from mycelial cells with a polyclonal serum raised against cell walls of this morphology. Analysis of the nucleotide sequence of a corresponding genomic DNA fragment revealed a single open reading frame which encodes a predicted protein of 321 amino acids with no significant homology to others in the databases. Disruption of the CSP37 gene by the method describ…

VoIP end-to-end performance in HSPA with packet age aided HSDPA scheduling

2008

In this paper, we present an enhanced VoIP scheduling for the high speed downlink packet access (HSDPA) in UMTS, which takes the age of the VoIP packet into account. The downlink capacity can be significantly improved by this way, especially for shorter uplink transmission delay. In order to quantify the achievable performance improvement, we present results obtained from extensive system-level uplink and downlink simulations. Inter alia, it is shown that using the proposed scheme can lead to an increase in the downlink cell capacity of up to 16%. By applying the proposed method, the downlink performance can be improved considerably while the uplink performance remains the same, which ensur…

Acute and chronic effects of combined endurance and strength training on blood leukocytes in untrained healthy men

2014

Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage.

2021

Background: Frailty is a major age-associated syndrome leading to disability. Oxidative damage plays a significant role in the promotion of frailty. The cellular antioxidant system relies on reduced nicotinamide adenine dinucleotide phosphate (NADPH) that is highly dependent on glucose 6-P dehydrogenase (G6PD). The G6PD-overexpressing mouse (G6PD-Tg) is protected against metabolic stresses. Our aim was to examine whether this protection delays frailty. Methods: Old wild-type (WT) and G6PD-Tg mice were evaluated longitudinally in terms of frailty. Indirect calorimetry, transcriptomic profile, and different skeletal muscle quality markers and muscle regenerative capacity were also investigate…

Moderate overexpression of glucose-6-phosphate dehydrogenase improves healthspan in mice. Implications in skeletal muscle regeneration

2019

An enormous increment in the average lifespan of diverse populations occurred worldwide in the 20th century. In the last 10–15 years, the importance has changed from extending average and even maximal longevity to favoring healthy aging, and many researchers have focused their studies on the aim at extending healthspan. Prolonging lifespan without taking care of improving healthspan can derive in a long time of living with disabilities and constitutes a risk factor for the old population to suffer a higher prevalence of aging-related diseases. Indeed, modern disease treatments frequently diminish mortality without any effect on the deterioration of overall health. Understanding the mechanis…

On the use of composite indicators for mobile communications network management in smart sustainable cities

2020

Beyond 5G networks will be fundamental towards enabling sustainable mobile communication networks. One of the most challenging scenarios will be met in ultra-dense networks that are deployed in densely populated areas. In this particular case, mobile network operators should benefit from new assessment metrics and data science tools to ensure an effective management of their networks. In fact, incorporating architectures allowing a cognitive network management framework could simplify processes and enhance the network&rsquo

Voice traffic bicasting enhancements in mobile HSPA network

2014

This paper discusses methods for improving the effectiveness of delivering voice traffic over High-Speed Downlink Packet Access (HSDPA) network by employing transmission diversity with Single-Frequency Dual-Cell (SF-DC) Aggregation that is part of the Multiflow specification. SF-DC Aggregation allows the user to be served at the same time by two different cells. The enhancements discussed in the paper capitalize strongly on the availability of the composed Channel Quality Indication (CQI) feedback at both serving cells. According to the results obtained from the network simulations, the ability to select the better channel for each voice transmission significantly decreases the required tra…