Search results for "HTL"
showing 10 items of 62 documents
Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs
2021
Class I SH3 domain-binding motifs generally comply with the consensus sequence [R/K]x0PxxP, the hydrophobic residue 0 being proline or leucine. We have studied the unusual 0 = Ala-specificity of SNX9 SH3 by determining its complex structure with a peptide present in eastern equine encephalitis virus (EEEV) nsP3. The structure revealed the length and composition of the n-Src loop as important factors determining specificity. We also compared the affinities of EEEV nsP3 peptide, its mutants, and cellular ligands to SNX9 SH3. These data suggest that nsP3 has evolved to minimize reduction of conformational entropy upon binding, hence acquiring stronger affinity, enabling takeover of SNX9. The R…
Comparison of actual and imagined execution of whole-body movements after a long exposure to microgravity
2003
Five cosmonauts were tested 30 days before a six-month space flight and also on the 2nd and the 6th day after their return to Earth. Cosmonauts performed and imagined a task that involved climbing two stairs to step onto a platform, jumping down with both feet and walking normally for a distance of 4 m. Durations of actual and imagined movements were measured by an electronic stopwatch. Results indicated that cosmonauts performed actual and imagined movements with similar durations before and after the space flight. However, the 2nd day after their return to Earth, cosmonauts significantly increased the durations of both actual and imagined movements. The durations of the imagined and actua…
Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and …
2015
AbstractAdult T-cell leukemia/lymphoma is a highly infiltrative neoplasia of CD4+ T-lymphocytes that occurs in about 5% of carriers infected with the deltaretrovirus human T-cell leukemia virus type 1 (HTLV-1). The viral oncoprotein Tax perturbs cellular signaling pathways leading to upregulation of host cell factors, amongst them the actin-bundling protein Fascin, an invasion marker of several types of cancer. However, transcriptional regulation of Fascin by Tax is poorly understood. In this study, we identified a triple mode of transcriptional induction of Fascin by Tax, which requires (1) NF-κB-dependent promoter activation, (2) a Tax-responsive region in the Fascin promoter, and (3) a p…
Einstellungen und Verhalten gegenüber geflüchteten Menschen : Ist die räumliche Distanz von Bedeutung?
2020
Die klassische Kontakthypothese aus der Forschung zu Fremdenfeindlichkeit postuliert einen negativen Zusammenhang: Je mehr und intensivere Kontakte zu einer ethnischen Minorität bestehen, desto eher werden Vorurteile reduziert und desto geringer sind fremdenfeindliche Einstellungen. Empirisch konnte dieser Effekt vielfach bestätigt werden. In unserem Beitrag untersuchen wir eine Erweiterung dieser „sozialen“ Kontakthypothese hin zu einer „räumlichen“ bzw. „geografischen“ Kontakthypothese. Konkret geht es um die Frage, ob Einstellungen gegenüber geflüchteten Menschen davon abhängen, inwieweit Befragte durch ihren Wohnstandort Kontakt bzw. eine räumliche Nähe zu Flüchtlingsunterkünften haben.…
Motor imagery
2015
International audience; Before participating in a space mission, astronauts undergo parabolic-flight and underwater training to facilitate their subsequent adaptation to weightlessness. Unfortunately, similar training methods can't be used to prepare re adaptation to planetary gravity. Here, we propose a quick, simple and inexpensive approach that could be used to prepare astronauts both for the absence and for the renewed presence of gravity. This approach is based on motor imagery (MI), a process in which actions are produced in working memory without any overt output. Training protocols based on MI have repeatedly been shown to modify brain circuitry and to improve motor performance in h…
Resource-efficient hardware implementation of a neural-based node for automatic fingerprint classification
2017
Modern mobile communication networks and Internet of Things are paving the way to ubiquitous and mobile computing. On the other hand, several new computing paradigms, such as edge computing, demand for high computational capabilities on specific network nodes. Ubiquitous environments require a large number of distributed user identification nodes enabling a secure platform for resources, services and information management. Biometric systems represent a useful option to the typical identification systems. An accurate automatic fingerprint classification module provides a valuable indexing scheme that allows for effective matching in large fingerprint databases. In this work, an efficient em…
Draft genomic sequence of Nereida ignava CECT 5292T, a marine bacterium of the family Rhodobacteraceae
2016
Nereida ignava strain 2SM4T (= CECT 5292T = DSM 16309T = CIP 108404T = CCUG 49433T) is a marine bacterium belonging to the Roseobacter group of the family Rhodobacteraceae within the class Alphaproteobacteria. The strain was isolated from sea water surrounding cultivated oysters 2–3 miles off the Mediterranean coast near Valencia (Spain) and was phylogenetically related to uncultured clones of gall symbiont bacteria of some species of Prionitis alga. Here we describe the genome sequence and annotation of this organism, the type strain of the single species of this genus. The genome comprised 2,888,349 bp, 2,872 protein-coding genes and 52 RNA genes. The annotation revealed the capacity to p…
Sensorimotor adaptation of point-to-point arm movements after spaceflight: the role of internal representation of gravity force in trajectory plannin…
2011
International audience; After an exposure to weightlessness, the central nervous system operates under new dynamic and sensory contexts. To find optimal solutions for rapid adaptation, cosmonauts have to decide whether parameters from the world or their body have changed and to estimate their properties. Here, we investigated sensorimotor adaptation after a spaceflight of 10 days. Five cosmonauts performed forward point-to-point arm movements in the sagittal plane 40 days before and 24 and 72 h after the spaceflight. We found that, whereas the shape of hand velocity profiles remained unaffected after the spaceflight, hand path curvature significantly increased 1 day after landing and return…
Prolonged exposure to microgravity modifies limb endpoint kinematics during the swing phase of human walking
2002
Many neurophysiological and behavioural studies suggested that the lower limb endpoint might be a centrally represented variable within the gravity reference frame and effectively controlled during the locomotion. This investigation examines the effects of prolonged exposure to microgravity upon lower limb endpoint kinematics. Seven cosmonauts were tested before and the 2nd day after a 6 month orbital mission. The spatio-temporal patterns of the limb extremity (malleolus) were analysed during the swing phase of the walk using a motion analysis system. Paths and velocity profiles of endpoint displacements were computed and compared for both the pre- and post-flight walking sessions. The resu…
Jet fragmentation transverse momentum distributions in pp and p-Pb collisions at √s, √sNN = 5.02 TeV
2021
Jet fragmentation transverse momentum (jT) distributions are measured in proton-proton (pp) and proton-lead (p-Pb) collisions at √sNN = 5.02 TeV with the ALICE experiment at the LHC. Jets are reconstructed with the ALICE tracking detectors and electromagnetic calorimeter using the anti-kT algorithm with resolution parameter R = 0.4 in the pseudorapidity range |η| < 0.25. The jT values are calculated for charged particles inside a fixed cone with a radius R = 0.4 around the reconstructed jet axis. The measured jT distributions are compared with a variety of parton-shower models. Herwig and Pythia 8 based models describe the data well for the higher jT region, while they underestimate the low…