Search results for "Ham"
showing 10 items of 2612 documents
Cancer relapse under chemotherapy: why TLR2/4 receptor agonists can help.
2007
Liver or lung metastases usually relapse under chemotherapy. Such life-threatening condition urgently needs new, systemic anticancer compounds, with original and efficient mechanisms of action. In B16 melanoma mice treated with cyclophosphamide, D'Agostini et al. [D'Agostini, C., Pica, F., Febbraro, G., Grelli, S., Chiavaroli, C., Garaci, E., 2005. Antitumour effect of OM-174 and Cyclophosphamide on murine B16 melanoma in different experimental conditions. Int. Immunopharmacol. 5, 1205-1212.] recently found that OM-174, a chemically defined Toll-like receptor(TLR)2/4 agonist, reduces tumor progression and prolongs survival. Here we review 149 articles concerning molecular mechanisms of TLR2…
Selection and characterization of a novel agonistic human recombinant anti-Trail-R2 minibody with anti-leukemic activity
2009
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising natural anticancer therapeutic agent because through its “death receptors”, TRAIL-R1 and TRAIL-R2, it induces apoptosis in many transformed tumor cells, but not in the majority of normal cells. Hence, agonistic compounds directed against TRAIL death receptors have the potential of being excellent cancer therapeutic agents, with minimal cytotoxicity in normal tissues. Here, we report the selection and characterization of a new single-chain fragment variable (scFv) to TRAIL-R2 receptor isolated from a human phage-display library, produced as minibody (MB), and characterized for the in vitro anti-leukemic tumoricid…
RNA2-encoded VP37 protein of Broad bean wilt virus 1 is a determinant of pathogenicity, host susceptibility, and a suppressor of post-transcriptional…
2020
Abstract Broad bean wilt virus 1 (BBWV‐1, genus Fabavirus, family Secoviridae) is a bipartite, single‐stranded positive‐sense RNA virus infecting many horticultural and ornamental crops worldwide. RNA1 encodes proteins involved in viral replication whereas RNA2 encodes two coat proteins (the large and small coat proteins) and two putative movement proteins (MPs) of different sizes with overlapping C‐terminal regions. In this work, we determined the role played by the small putative BBWV‐1 MP (VP37) on virus pathogenicity, host specificity, and suppression of post‐transcriptional gene silencing (PTGS). We engineered a BBWV‐1 35S‐driven full‐length cDNA infectious clone corresponding to BBWV‐…
Data from: Effects of undergrowth removal and edge proximity on ground beetles and vascular plants in urban boreal forests
2019
Urban forests are regularly managed for human safety and aesthetic reasons, but they are crucial habitat for many species. Removals of undergrowth occur commonly in these forests, yet the ecological consequences of these operations are poorly understood. We sampled ground beetles (Coleoptera, Carabidae) and vascular plants along 20-m edge gradients in Finnish urban forests, in five stands treated 0.5−2.5 years earlier with undergrowth removal and in five untreated stands. We hypothesized that undergrowth removal and edge proximity would benefit opportunistic and open-habitat species, whereas shady-habitat species would be affected negatively. (1) Regarding carabids, diversity and evenness i…
Hodge Numbers for the Cohomology of Calabi-Yau Type Local Systems
2014
We determine the Hodge numbers of the cohomology group \(H_{L^{2}}^{1}(S, \mathbb{V}) = H^{1}(\bar{S},j_{{\ast}}\mathbb{V})\) using Higgs cohomology, where the local system \(\mathbb{V}\) is induced by a family of Calabi-Yau threefolds over a smooth, quasi-projective curve S. This generalizes previous work to the case of quasi-unipotent, but not necessarily unipotent, local monodromies at infinity. We give applications to Rohde’s families of Calabi-Yau 3-folds.
Cohomologie relative des applications polynomiales
2001
Let F be a polynomial dominating mapping from Cn to Cq with n>q. We study the de Rham cohomology of the fibres of F, and its relative cohomology groups. Let us fix a strictly positive weighted homogeneous degree on C[x1,…,xn]. With the leading terms of the coordinate functions of F, we construct a fibre of F that is said to be “at infinity”. We introduce the cohomology groups of F at infinity. These groups, denoted by Hk(F−1(∞)), enable us to study all the other cohomology groups of F. For instance, if the fibre at infinity has an isolated singularity at the origin, we prove that any quasi-homogeneous basis of Hn−q(F−1(∞)) provides a basis of all groups Hn−q(F−1(y)), as well as a basis of t…
New Families of Symplectic Runge-Kutta-Nyström Integration Methods
2001
We present new 6-th and 8-th order explicit symplectic Runge-Kutta-Nystrom methods for Hamiltonian systems which are more efficient than other previously known algorithms. The methods use the processing technique and non-trivial flows associated with different elements of the Lie algebra involved in the problem. Both the processor and the kernel are compositions of explicitly computable maps.
Analytic vectors, anomalies and star representations
1989
It is hinted that anomalies are not really anomalous since (at least in characteristic examples) they can be related to a lack of common analytic vectors for the Hamiltonian and the observables. We reanalyze the notions of analytic vectors and of local representations of Lie algebras in this light, and show how the notion of preferred observables introduced in the deformation (star product) approach to quantization may help give an anomaly-free formulation to physical problems. Finally, some remarks are made concerning the applicability of these considerations to field theory, especially in two dimensions.
Karyotype Abnormalities in a Variant Chinese Hamster Cell Line Resistant to Methyl Methanesulphonate
2004
A variant cell population, isolated from V79-CI 3 Chinese hamster cells after two consecutive treatments with methyl methanesulphonate (MMS), was found to be highly resistant to killing by this alkylating agent. The resistant cell line was cytogenetically characterized both by the presence of a stable translocation involving metacentric chromosome 2 and acrocentric chromosome 6 and by a supernumerary chromosome originated by the duplication of a small telocentric chromosome. This cell population also showed a transient transformed phenotype, seen as formation of transformed foci containing cells with high chromosomes counts and multiple chromosomal aberrations. As MMS-resistance and karyoty…
Mismatch G-T binding activity and MSH2 expression is quantitatively related to sensitivity of cells to methylating agents
1998
To elucidate mechanisms involved in alkylating drug resistance, Chinese hamster cells resistant to methylating agents have been generated upon transfection with human DNA. Here it is shown that these Chinese hamster ovary (CHO) variants exhibit the tolerance phenotype: they are alkyltransferase deficient (Mex-), cross-resistant to 6-thioguanine, exhibit reduced G-T binding (MutS alpha) activity and express the mismatch repair protein MSH2 at a significantly lower level than the corresponding control. By comparing wild-type cells with different tolerant strains that show gradual differences in resistance to methylating agents, it was shown that both the G-T binding activity and the amount of…