Search results for "Hand"
showing 10 items of 1364 documents
String kernels and high-quality data set for improved prediction of kinked helices in α-helical membrane proteins.
2011
The reasons for distortions from optimal α-helical geometry are widely unknown, but their influences on structural changes of proteins are significant. Hence, their prediction is a crucial problem in structural bioinformatics. For the particular case of kink prediction, we generated a data set of 132 membrane proteins containing 1014 manually labeled helices and examined the environment of kinks. Our sequence analysis confirms the great relevance of proline and reveals disproportionately high occurrences of glycine and serine at kink positions. The structural analysis shows significantly different solvent accessible surface area mean values for kinked and nonkinked helices. More important, …
Synthesis and application of β-substituted Pauson-Khand adducts: trifluoromethyl as a removable steering group.
2013
The reaction between alkynes (I) and norbornadiene (II) affords the β-substituted Pauson—Khand adducts (III) as single regioisomers and the trifluoromethyl steering group can be easily removed in the presence of DBU and water.
Conformational investigation of α,β-dehydropeptides. X. Molecular and crystal structure of Ac-ΔAla-NMe2 compared with those of Ac-L-Ala-NMe2, Ac-DL-A…
2002
A series of three homologous dimethyldiamides Ac-DeltaAla-NMe2, Ac-L-Ala-NMe2 and Ac-DL-Ala-NMe2 has been synthesized and the structures of these amides determined from single-crystal X-ray diffraction data. To learn more about the conformational preferences of compounds studied, the fully relaxed (phi-psi) conformational energy maps in vacuo (AM1) of Ac-DeltaAla-NMe2 and Ac-L-Ala-NMe2 were obtained, and the calculated minima reoptimized with the DFT/B3LYP/6-31G** method. The crystal-state results have been compared with the literature data. Ac-DeltaAla-NMe2 and other alpha,beta-dehydroamino acid dimethyldiamides, Ac-DeltaXaa-NMe2 adopt the conservative conformation of the torsion angles ph…
Asymmetric Allylation/Pauson-Khand Reaction: A Simple Entry to Polycyclic Amines. Application to the Synthesis of Aminosteroid Analogues
2014
Asymmetric allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson-Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.
Mettre à jour les réseaux politiques ou définir le populisme ? L'attitude des médias face à la droite populiste allemande
2018
International audience; En Allemagne, l’espace politique entre la droite parlementaire et l’extrême droite est peu structuré. Les limites entre chaque camp manquent de clarté et laissent la place au développement d’une zone intermédiaire où s’exprime un populisme rassemblant des personnalités venues de divers horizons (membres de partis politiques, d’associations, intellectuels). En effet, ces personnes font office de passeurs entre les deux pôles, et elles s’illustrent dans les médias en prenant position dans des débats politiques particuliers qu’elles animent par leur engagement volontiers polémique (souveraineté nationale, rejet de l’Europe, lutte contre l’immigration…).Cet article analy…
Minimizing the cycle time in serial manufacturing systems with multiple dual-gripper robots
2006
Robots are being used more and more extensively as material-handling systems for automated manufacturing systems. This is especially true for dual-gripper robots whose in-process buffer (the robot's second gripper) constitutes a further element of flexibility. When the number of stations to be served is high and the set of activities the robot must execute is great, the system throughput may depend on robot capability rather than on process times. In such conditions, the use of several robots leads to an increase in system productivity. Obviously, the design and the management of such a handling system becomes more complex: the minimum number of robots required, the work stations to be serv…
2020
Abstract Patient handover is an important part for information transfer between medical professionals in a clinical setting. Yet, in current medical education, these conversations are only trained sparsely, since they are costly to perform as they take place in offsite courses and are led by experts over several days. Virtual reality (VR)-based training courses could increase the availability of training, by eliminating travel costs and reducing the time-commitment of the teaching experts. This work presents a VR prototype of a multi-user training and examination application for patient handover. To ensure a similar interaction quality to its current real world counterpart, this work used o…
T-pattern analysis for the study of temporal structure of animal and human behavior : a comprehensive review
2014
A basic tenet in the realm of modern behavioral sciences is that behavior consists of patterns in time. For this reason, investigations of behavior deal with sequences that are not easily perceivable by the unaided observer. This problem calls for improved means of detection, data handling and analysis. This review focuses on the analysis of the temporal structure of behavior carried out by means of a multivariate approach known as T-pattern analysis. Using this technique, recurring sequences of behavioral events, usually hard to detect, can be unveiled and carefully described. T-pattern analysis has been successfully applied in the study of various aspects of human or animal behavior such …
Multivariate regression analysis applied to the calibration of equipment used in pig meat classification in Romania.
2016
This paper highlights the statistical methodology used in a dissection experiment carried out in Romania to calibrate and standardize two classification devices, OptiGrade PRO (OGP) and Fat-o-Meat'er (FOM). One hundred forty-five carcasses were measured using the two probes and dissected according to the European reference method. To derive prediction formulas for each device, multiple linear regression analysis was performed on the relationship between the reference lean meat percentage and the back fat and muscle thicknesses, using the ordinary least squares technique. The root mean squared error of prediction calculated using the leave-one-out cross validation met European Commission (EC…