Search results for "Hdl"
showing 10 items of 298 documents
Saturated and unsaturated free fatty acids (FFA) modulate differently HDL uptake in hepatoma HEPG2 cells
2003
Ultrasonidos de alta densidad y definición en tiempo real (HDLive US) en ginecología y reproducción
2013
En la actualidad nadie discute que la introducción de los ultrasonidos en el campo diagnóstico ha sido uno de los mayores, quizás el mayor, avance de nuestra especialidad. Constituye también la base fundamental del control clínico de todas las técnicas de Reproducción Asistida (RA) que hoy empleamos. Hoy no se conciben éstas sin ecografía. Desde la introducción de la ecografía abdominal en la década de los 70 con la descripción de los tipos de líneas endometriales y las diversas imágenes foliculares y del cuerpo lúteo, la introducción en la década de los 80 de la ecografía vaginal ha supuesto, indiscutiblemente, el mayor avance en el campo de los ultrasonidos. La ecografía vía vaginal ha si…
Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms
2010
Background— Cholesteryl ester transfer protein (CETP) inhibitors raise high-density lipoprotein (HDL) cholesterol, but torcetrapib, the first-in-class inhibitor tested in a large outcome trial, caused an unexpected blood pressure elevation and increased cardiovascular events. Whether the hypertensive effect resulted from CETP inhibition or an off-target action of torcetrapib has been debated. We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target. Methods and Results— We compared the effect of CETP single-nucleotide polymorphisms …
Dysfunctional High-Density Lipoproteins Are Associated With a Greater Incidence of Acute Coronary Syndrome in a Population at High Cardiovascular Risk
2020
Background: Studies have failed to establish a clear link between high-density lipoprotein (HDL) cholesterol and cardiovascular disease, leading to the hypothesis that the atheroprotective role of HDL lies in its biological activity rather than in its cholesterol content. However, to date, the association between HDL functional characteristics and acute coronary syndrome has not been investigated comprehensively. Methods: We conducted a case-control study nested within the PREDIMED (Prevención con Dieta Mediterránea) cohort, originally a randomized trial in which participants followed a Mediterranean or low-fat diet. Incident acute coronary syndrome cases (N=167) were individually matched …
Description of a sicilian family with hyper-alpha-lipoproteinemia with deficit of CETP activity
2002
Disturbances in cholesterol, bile acid and glucose metabolism in peroxisomal 3-ketoacylCoA thiolase B deficient mice fed diets containing high or low…
2014
SPE IPM UB; International audience; : The peroxisomal 3-ketoacyl-CoA thiolase B (ThB) catalyzes the thiolytic cleavage of straight chain 3-ketoacyl-CoAs. Up to now, the ability of ThB to interfere with lipid metabolism was studied in mice fed a routinely laboratory chow enriched or not with the synthetic agonist Wy14,643, a pharmacological activator of the nuclear hormone receptor PPARα. The aim of the present study was therefore to determine whether ThB could play a role in obesity and lipid metabolism when mice are chronically fed a synthetic High Fat Diet (HFD) or a Low Fat Diet (LFD) as a control diet. To investigate this possibility, wild-type (WT) mice and mice deficient for Thb (Thb(…
Menopausal Status and Physical Activity Are Independently Associated With Cardiovascular Risk Factors of Healthy Middle-Aged Women: Cross-Sectional a…
2019
Cardiovascular disease (CVD) is the primary cause of mortality in women in developed countries. CVD risk rises with age, yet for women there is a rapid increase in CVD risk that occurs after the onset of menopause. This observation suggests the presence of factors in the middle-aged women that accelerate the progression of CVD independent of chronological aging. Leisure time physical activity (LTPA) is a well-established protective factor against CVD. However, its role in attenuating atherogenic lipid profile changes and CVD risk in post-menopausal women has not been well-established. The present study is part of the Estrogenic Regulation of Muscle Apoptosis (ERMA) study, a population-based…
Should we routinely measure low-density and high-density lipoprotein subclasses?
2009
Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) plasma populations are composed of heterogeneous subfractions that are different in size, density and protein/lipid content. There is increasing evidence that small, dense LDL particles are strongly associated with higher cardiovascular disease risk. Similarly, several studies have investigated whether smaller HDL particles are more protective than their larger counterparts and more recent findings suggest that small, dense HDL has significantly higher atheroprotective activity than larger L HDL. Yet, certain impairments of the protein/lipid content in small, dense HDL may decrease its antiatherogenic capacity or even induce p…
Malformaciones uterinas (anomalías müllerianas): posibilidades diagnósticas con ecografía 3D/4D y ecografía de alta definición en tiempo real
2019
El sistema reproductivo femenino se forma a partir de los conductos müllerianos, que durante el desarrollo embrionario se fusionan para crear las trompas de Falopio, el útero, el cérvix y la porción superior de la vagina. Su desarrollo está inducido por los conductos de Wolf que actúan como elementos guía. Este proceso tiene lugar entre la semana sexta y la vigésima de vida fetal. Las malformaciones uterinas constituyen un grupo heterogéneo de anomalías congénitas que resultan de un fallo en una de las tres fases del desarrollo de los conductos paramesonéfricos o de Müller: fase de organogénesis o desarrollo, fase de fusión y fase de reabsorción del septo. Muchas mujeres con estas anomalías…
The differential effects of thiazolidindiones on atherogenic dyslipidemia in type 2 diabetes: what is the clinical significance?
2008
Diabetic dyslipidemia is typically characterized by an increase in plasma triglycerides, a decrease in high-density lipoprotein cholesterol and a concomitant increase in atherogenic small dense low-density lipoproteins. Thiazolidindiones are able to lower the levels of fasting glucose and glycated hemoglobin significantly by improving insulin sensitivity, as well as improving some aspects of diabetic dyslipidemia: total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol tend to increase while triglycerides are generally decreased.This paper reviewed the effects of pioglitazone and rosiglitazone on atherogenic diabetic dyslipidemia, in particular on sma…