Search results for "Healthy Aging"
showing 10 items of 82 documents
Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers
2021
The main epigenetic features in aging are: reduced bulk levels of core histones, altered pattern of histone post-translational modifications, changes in the pattern of DNA methylation, replacement of canonical histones with histone variants, and altered expression of non-coding RNA. The identification of epigenetic mechanisms may contribute to the early detection of age-associated subclinical changes or deficits at the molecular and/or cellular level, to predict the development of frailty, or even more interestingly, to improve health trajectories in older adults. Frailty reflects a state of increased vulnerability to stressors as a result of decreased physiologic reserves, and even dysregu…
The complexity of loneliness.
2018
Loneliness is a prevalent and global problem for adult populations, and a number of different studies have linked it to multiple chronic conditions, including: heart disease, lung disease, cardiovascular disease, hypertension, atherosclerosis, stroke, and metabolic disorders, such as obesity and metabolic disease. Is a major predictor of psychological problems, such as depression, psychological stress, and anxiety. Loneliness is linked to overall morbidity and mortality in adult populations. But limited interventions have demonstrated long-term effectiveness in reducing loneliness in adults with these same chronic conditions. Our research of the extant literature addresses the following que…
YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING
2022
Ageing is intimately connected to the induction of cell senescence(1,2), but why this is so remains poorly understood. A key challenge isthe identification of pathways that normally suppress senescence, are lost during ageing and are functionally relevant to oppose ageing(3). Here we connected the structural and functional decline of ageing tissues to attenuated function of the master effectors of cellular mechanosignalling YAP and TAZ. YAP/TAZ activity declines during physiological ageing in stromal cells, and mimicking such decline through genetic inactivation of YAP/TAZ in these cells leads to accelerated ageing. Conversely, sustaining YAP function rejuvenates old cells and opposes the e…
Healthy ageing and Mediterranean diet: A focus on hormetic phytochemicals
2021
Abstract Mediterranean diet (MedDiet) is rich in fruits and vegetables associated with longevity and a reduced risk of several age-related diseases. It is demonstrated that phytochemicals in these plant products enhance the positive effects of MedDiet by acting on the inflammatory state and reducing oxidative stress. Evidence support that these natural compounds act as hormetins, triggering one or more adaptive stress-response pathways at low doses. Activated stress-response pathways increase the expression of cytoprotective proteins and multiple genes that act as lifespan regulators, essential for the ageing process. In these ways, the hormetic response by phytochemicals such as resveratro…
“I do those things to pass the time.”: Active ageing during fourth age
2021
Active ageing is a dominant but disputed discourse in the field of ageing. Since it is usually associated with the third age, this article will focus on the active ageing of older adults who need care and services, who are known as the fourth agers. Our data consists of interviews collected from 16 older adults. We analysed the data through content analysis that was guided by the Active Ageing Index (AAI) that is a measuring tool concerning active ageing. According to our results, active ageing during the fourth age can be understood through the lens of small actions and precarity. Although some actions had to be given up or modified, participants were active in various ways, and help from …
Reliability of genomic variants across different next-generation sequencing platforms and bioinformatic processing pipelines
2021
Abstract Background Next Generation Sequencing (NGS) is the fundament of various studies, providing insights into questions from biology and medicine. Nevertheless, integrating data from different experimental backgrounds can introduce strong biases. In order to methodically investigate the magnitude of systematic errors in single nucleotide variant calls, we performed a cross-sectional observational study on a genomic cohort of 99 subjects each sequenced via (i) Illumina HiSeq X, (ii) Illumina HiSeq, and (iii) Complete Genomics and processed with the respective bioinformatic pipeline. We also repeated variant calling for the Illumina cohorts with GATK, which allowed us to investigate the e…
THE OSCILLATORY MECHANISMS ASSOCIATED WITH SYNTACTIC BINDING IN HEALTHY AGEING
2020
Older adults frequently display differential patterns of brain activity compared to young adults in the same task, alongside widespread neuroanatomical changes. Differing functional activity patterns in older adults are commonly interpreted as being compensatory (e.g., Cabeza, Locantore & McIntosh, 2002). We examined the oscillatory activity in the EEG during syntactic binding in young and older adults, as well as the relationship between oscillatory activity and behavioural performance on a syntactic judgement task within the older adults. 19 young and 41 older adults listened to two-word sentences that differentially load onto morpho-syntactic binding: correct syntactic binding (m…
The association between the Mediterranean diet and magnetic resonance parameters for knee osteoarthritis: data from the Osteoarthritis Initiative
2018
The Mediterranean diet appears to be beneficial for osteoarthritis (OA), but the few data available regarding the association between the diet and the condition are limited to X-ray and clinical findings. The current study aimed to investigate the association between adherence to the Mediterranean diet and knee cartilage morphology, assessed using magnetic resonance (MRI) in a cohort of North American participants. Seven hundred eighty-three participants in the Osteoarthritis Initiative (59.8% females; mean age 62.3 years) in possession of a MRI assessment (a coronal 3D FLASH with Water Excitation MR sequence of the right knee) were enrolled in our cross-sectional study. Adherence to the Me…
Nutrients associated with diseases related to aging: a new healthy aging diet index for elderly population
2018
espanolIntroduccion: suelen usarse diversos indices dieteticos para medir la calidad de la nutricion en edades avanzadas. Sin embargo, ninguno de ellos fue disenado para evaluar la nutricion con el objetivo de evitar discapacidades en la poblacion anciana. Objetivos: identificar en la literatura cientifica los “nutrientes e ingestas” involucrados en el envejecimiento, asi como proponer un nuevo indice, considerando esta informacion, que sirva para evaluar la calidad de la nutricion con objeto de prevenir enfermedades relacionadas con el envejecimiento. Metodos: se realizo una revision bibliografica, obteniendo informacion sobre los nutrientes asociados con el envejecimiento. Todos estos nut…
SHAPES secure cloud platform for healthcare solutions and services
2020
The SHAPES project is an ambitious endeavour that gathers stakeholders from across Europe to create, deploy and pilot at large-scale a EU-standardised open platform incorporating and integrating a broad range of solutions, including technological, organisational, clinical, educational and societal, to enable the ageing population of Europe to remain healthy, active and productive, as well as to maintain a high quality of life and sense of wellbeing for the longest time possible. Not only each digital solution will be ethical, legal and appropriate for users, but also the results will align with the full and ethically responsible end-to-end exploitation of the new functionalities empowered b…