Search results for "Hemin"
showing 10 items of 93 documents
Le monde des cheminots dans le miroir du Parlement. Un regard sur la « réforme ferroviaire » de 2013-2014
2014
International audience; La restructuration des chemins de fer français paraît devenue – depuis une vingtaine d’années – une entreprise continue. Diverses réformes se sont en effet succédées tenant tant à l’économie des chemins de fer et, en particulier, à leur ouverture à la concurrence dans un contexte de libéralisation porté par l’Union européenne, qu’aux modes de gestion des personnels ou à leur système de protection sociale (et notamment de retraite). Sans refaire toute la généalogie de ces réformes – et notamment de la restructuration des chemins de fer autour de deux entités (RFF et la SNCF) à la fin des années 1990 – cette communication propose de décrypter et d’analyser la dernière …
Les salaires à la SNCF, inflexion néolibérale et résilience du statut
2012
National audience
Novel scaffold of natural compound eliciting sweet taste revealed by machine learning
2020
Abstract Sugar replacement is still an active issue in the food industry. The use of structure-taste relationships remains one of the most rational strategy to expand the chemical space associated to sweet taste. A new machine learning model has been setup based on an update of the SweetenersDB and on open-source molecular features. It has been implemented on a freely accessible webserver. Cellular functional assays show that the sweet taste receptor is activated in vitro by a new scaffold of natural compounds identified by the in silico protocol. The newly identified sweetener belongs to the lignan chemical family and opens a new chemical space to explore.
Host-Nonspecific Iron Acquisition Systems and Virulence in the Zoonotic Serovar of Vibrio vulnificus
2014
ABSTRACT The zoonotic serovar of Vibrio vulnificus (known as biotype 2 serovar E) is the etiological agent of human and fish vibriosis. The aim of the present work was to discover the role of the vulnibactin- and hemin-dependent iron acquisition systems in the pathogenicity of this zoonotic serovar under the hypothesis that both are host-nonspecific virulence factors. To this end, we selected three genes for three outer membrane receptors ( vuuA , a receptor for ferric vulnibactin, and hupA and hutR , two hemin receptors), obtained single and multiple mutants as well as complemented strains, and tested them in a series of in vitro and in vivo assays, using eels and mice as animal models. Th…
Multitasking Water-Soluble Synthetic G-Quartets: From Preferential RNA-Quadruplex Interaction to Biocatalytic Activity
2013
Natural G-quartets, a cyclic and coplanar array of four guanine res- idues held together through a Watson- Crick/Hoogsteen hydrogen-bond net- work, have received recently much at- tention due to their involvement in G- quadruplex DNA, an alternative higher-order DNA structure strongly suspected to play important roles in key cellular events. Besides this, syn- thetic G-quartets (SQ), which artificial- ly mimic native G-quartets, have also been widely studied for their involve- ment in nanotechnological applications (i.e., nanowires, artificial ion channels, etc.). In contrast, intramolecular syn- thetic G-quartets (iSQ), also named template-assembled synthetic G-quar- tets (TASQ), have been…
Prediction of perception using structure–activity models
2016
IntroductionThe possible link between the molecular structure and a biological activity was pointed out by Linus Pauling (1946) just before the middle of the 20th century. Nevertheless, this concept has been already suggested a century before by Emil Fisher and “lock-and-key” theory: “To use a metaphor, I would say that enzyme and glucoside are such lock and key that fit together in order to exert a reciprocal chemical effect on each other”a (Fischer, 1894). The notion that the biological properties of a compound would be a function of its chemical characteristics is now well admitted, and is closely linked to that of pharmacophore. The pharmacophore concept is related to the interaction of…
Deciphering the DNAzyme activity of multimeric quadruplexes: insights into their actual role in the telomerase activity evaluation assay.
2011
The end of human telomeres is comprised of a long G-rich single-stranded DNA (known as 3'-overhang) able to adopt an unusual three-dimensional "beads-on-the-string" organization made of consecutively stacked G-quadruplex units (so-called quadruplex multimers). It has been widely demonstrated that, upon interaction with hemin, discrete quadruplexes acquire peroxidase-mimicking properties, oxidizing several organic probes in H(2)O(2)-rich conditions; this property, known as DNAzyme, has found tens of applications in the last two decades. However, little is known about the DNAzyme activity of multimeric quadruplexes; this is an important question to address, especially in light of recent repor…
A multilevel statistical toolkit to study animal social networks: the Animal Network Toolkit Software (ANTs) R package
2020
Abstract The possible role played by individual attributes, sociodemographic characteristics and/or ecological pressures in the interaction between animals and the development of social relationships between them is of great interest in animal ecology and evolutionary biology. Social Network Analysis is an ideal tool to study these types of questions. The Animal Network Toolkit Software (ANTs) R package was specifically developed to provide all the different social network analysis techniques currently used in the study of animal social networks. This global package enables users to (1) compute global, polyadic and nodal network measures; (2) perform data randomisation: data stream and netw…
Dzimumu attiecību attēlojums E. Hemingveja romānā „Ēdenes dārzs”
2015
Bakalaura darbā analizēts dzimumu attiecību attēlojums, androgēnos tēlu nozīme un dzimuma loma maiņas Ernesta Hemingveja romānā “Ēdenes dārzs”. Pētījuma teorētiskā daļa sastāv no literatūras pārskata par šo tēmu. Darba praktiskā daļa veltīta Ernesta Hemingveja romāna ”Ēdenes dārzs” analīzei. Pētījuma mērķis ir analizēt dzimuma attiecību atainojumu Ernesta Hemingveja romānā “Ēdenes dārzs”. Secinājumi ir balstīti uz teorētisko avotu un Ernesta Hemingveja romāna “Ēdenes dārzs” analīzi. Iegūtie dati deva iespēju atrast būtiskākās īpatnības šajā romānā, kas saistītās ar dzimumu un modernismu. Pētījuma rezultātus un secinājumus var izmantot studenti savos zinātniskajos darbos par dzimumu un moder…
Le vin de Champagne : de la visite à l’oenotrourisme, un chemin difficile
2014
International audience