Search results for "Hemodynamic"
showing 10 items of 526 documents
A Simple Cardiovascular Model for the Study of Hemorrhagic Shock
2020
Hemorrhagic shock is the number one cause of death on the battlefield and in civilian trauma as well. Mathematical modeling has been applied in this context for decades; however, the formulation of a satisfactory model that is both practical and effective has yet to be achieved. This paper introduces an upgraded version of the 2007 Zenker model for hemorrhagic shock termed the ZenCur model that allows for a better description of the time course of relevant observations. Our study provides a simple but realistic mathematical description of cardiovascular dynamics that may be useful in the assessment and prognosis of hemorrhagic shock. This model is capable of replicating the changes in mean …
Extravascular Lung Water Does Not Increase in Hypovolemic Patients after a Fluid-Loading Protocol Guided by the Stroke Volume Variation
2012
Introduction. Circulatory failure secondary to hypovolemia is a common situation in critical care patients. Volume replacement is the first option for the treatment of hypovolemia. A possible complication of volume loading is pulmonary edema, quantified at the bedside by the measurement of extravascular lung water index (ELWI). ELWI predicts progression to acute lung injury (ALI) in patients with risk factors for developing it. The aim of this study was to assess whether fluid loading guided by the stroke volume variation (SVV), in patients presumed to be hypovolemic, increased ELWI or not.Methods. Prospective study of 17 consecutive postoperative, fully mechanically ventilated patients dia…
Dynamic computed tomography: a novel technique to study lung aeration and atelectasis formation during experimental CPR
2002
Objective: To develop an image based technique to study the effect of different ventilatory strategies on lung ventilation and alveolar recruitment during cardiopulmonary resuscitation (CPR). Design: (1) Technical development of the following components: (a) construction of an external chest compression device, which does not interfere with CT imaging, and (b) development of a software tool to detect lung parenchyma automatically and to calculate radiological density parameters. (2) Feasibility studies: three strategies of CPR ventilation were performed and imaged in one animal each (pigs, 25 kg): volume-constant ventilation (VCV), no ventilation, or continuous airway pressure (CPAP). One m…
Can Ventricular Resynchronization Reduce Atrial Fibrillation Recurrences?
2003
In recent years a new pacing therapy has been proposed for patients affected by heart failure (HF) in order to reduce inter- [1,2], intra- [3,4], and atrioventricular [5] (AV) dyssynchrony. Cardiac resynchronization therapy (CRT) has the goal of correcting these hemodynamic disorders, thus improving left ventricular (LV) performance. The benefits of CRT have been evaluated in a series of clinical trials [6-10].
m.quadriceps statisku slodzi pavadošās hemodinamiskās reakcijas augšstilba maģistrālo artēriju gultnēs
2013
m.quadriceps statisku slodzi pavadošās hemodinamiskās reakcijas augšstilba maģistrālo artēriju gultnēs Pētījums veltīts perifēro artēriju un pretestības asinsvadu tonusa regulācijas īpatnību izpētei, reģionālai muskuļu asinsvadu gultnei iekļaujoties dažāda rakstura hemodinamiskās reakcijās. Promocijas darba pirmajā etapā tika veikti tālākā pētījumā izmantojamo metožu teorētiskā pamatojuma un praktiskās realizācijas pilnveidojumi: fotopletizmogrāfijas metodei – audu tilpuma pulsa un atsevišķas artērijas pulsa reģistrācijas metožu informativitātes salīdzinājums, artēriju ultrasonogrāfijas metodei – oriģinālas programmatūras izstrāde un aprobācija artērijas morfometrisko un asins plūsmas param…
Stable bioenergetic status despite substantial changes in blood flow and tissue oxygenation in a rat tumour.
1994
Experiments on s.c. rat tumours (DS sarcoma) were performed to determine whether chronic or acute changes in tumour perfusion necessarily lead to changes in tissue oxygenation and bioenergetic status since, as a rule, blood flow is thought to be the ultimate determinant of the tumour bioenergetic status. Based on this study, there is clear experimental evidence that growth-related or acute (following i.v. administration of tumour necrosis factor alpha) decreases in tumour blood flow are accompanied by parallel alterations in tissue oxygenation. In contrast, tumour energy status remains stable as long as flow values do not fall below 0.4-0.5 ml g-1 min-1, and provided that glucose as the mai…
Acute changes of systemic parameters in tumour-bearing rats, and of tumour glucose, lactate, and ATP levels upon local hyperthermia and/or hyperglyca…
1991
Arterial blood pressure and relevant parameters of the arterial blood (O2 and CO2 tensions, pH, haematocrit, serum electrolytes and osmolality) were determined in tumour-bearing rats upon local hyperthermia (HT) and/or hyperglycaemia (HG). Tumour heating was performed in a saline bath (44 degrees C) for 120 min; hyperglycaemia was induced by i.v. infusion of 40% glucose solution for 150 min [blood glucose levels: 35-40 mM during heating; total amount of glucose: 1.19 g/100 g body wt.; infusion rates: 0.31 ml (100 g body wt.)-1 min-1 for 2 min, 0.02 ml (100 g body wt.)-1 min-1 for 88 min, and 0.01 ml (100 g body wt.)-1 min-1 for 60 min]. Immediately after treatment, glucose, lactate and ATP …
Effects of Strength Training and Reduced Training on Functional Performance and Metabolic Health Indicators in Middle-Aged Men
2007
Changes in muscular fitness and metabolic health indicators were examined in 22 men (57.9 +/- 6.6 years, BMI 24.5 +/- 2.6 kg/m (2)) and 21 control men (58.2 +/- 6.1 years, BMI 25.4 +/- 2.8 kg/m (2)) during two consecutive 21-week periods: 1) whole body progressive strength training (ST: twice a week), and 2) continued reduced training (CRT: 3 ST sessions/2 weeks, n = 17 + 17). After the 21-week ST period, maximal strength of leg extensors increased in the ST group by 19.6 +/- 7.6 % vs. 2.8 +/- 4.4 % (p < 0.001) and also 10-m walking time and 10-step stair-climbing time shortened by - 17.2 +/- 7.6 % vs. 4.1 +/- 3.9 % (p < 0.01) and by - 8.2 +/- 6.8 % vs. - 3.0 +/- 6.8 % (p < 0.05) compared t…
The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model b…
2014
Objective In diabetes, vascular dysfunction is characterized by impaired endothelial function due to increased oxidative stress. Empagliflozin, as a selective sodium-glucose co-transporter 2 inhibitor (SGLT2i), offers a novel approach for the treatment of type 2 diabetes by enhancing urinary glucose excretion. The aim of the present study was to test whether treatment with empagliflozin improves endothelial dysfunction in type I diabetic rats via reduction of glucotoxicity and associated vascular oxidative stress. Methods Type I diabetes in Wistar rats was induced by an intravenous injection of streptozotocin (60 mg/kg). One week after injection empagliflozin (10 and 30 mg/kg/d) was adminis…
Mortality of ruptured abdominal aortic aneurysm with selective use of endovascular repair
2009
The aim of this review was to examine the results over a seven-year period of treatment for ruptured abdominal aortic aneurysm (RAAA). From 2002 on, our tertiary referral centre offered both open and endovascular (EVAR) treatment modalities for RAAA. All patients with a proven RAAA who were admitted into our hospital were included. Primary outcome measure was surgical mortality. In total 261 patients were admitted with suspicion of acute AAA. Of these, 175 (67%) had a RAAA, confirmed by computed tomography-scanning or at laparotomy. One hundred and fifty-nine patients (90.9%) were treated, 114 by open repair and 45 by EVAR. Overall mortality of patients treated was 25.2%, with an open repai…