Search results for "Hepatocellular"

Alteration of the YY1/RKIP ratio is a frequent event in hepatocellular carcinoma

2009

Targeting NUPR1 with the Small Compound ZZW-115 Is an Efficient Strategy to Treat Hepatocellular Carcinoma

2020

International audience; HCC is a highly lethal malignancy with Sorafenib as the only molecularly targeted drug. The multifunctional stress-associated protein, NUPR1, plays an essential role in controlling cell growth, migration, invasion and Sorafenib resistance in HCC. We report here that NUPR1 expression is absent in healthy liver and it is progressively upregulated in HCC premalignant lesions such as hepatitis and cirrhosis with a maximum expression in HCC samples, highlighting that NUPR1 is a potential drug target for HCC. We therefore assessed in this work, ZZW-115, a strong inhibitor of NUPR1, as a promising candidate for the treatment of HCC. We validated its extraordinary antitumor …

Rapamycin and Zoledronic Acid strongly retard growth of advanced murine hepatocellular carcinoma via skewing and activation of innate and adaptive im…

2018

Etude des facteurs nutritionnels et métaboliques de la cancérogenèse hépatique chez des patients atteints de cirrhose

2019

Hepatocellular Carcinoma (HCC) is worldwide the 5th most common diagnosed cancer in men and the 7th in women and the 4th cause of cancer death with a median survival between 10 and 11 months. The incidence rate in France is relatively high (7.8/100 000 with 10 624 estimated new cases in 2018). HCC prognosis is very poor due to the difficulty to diagnose it at an early stage. Around 80% of HCC occur in the setting of cirrhosis, mainly caused by alcoholism, chronic infections with HBV and HCV or metabolic syndrome. Cirrhotic patients have a high-risk to develop chronic inflammation or other liver complications that can progress toward cancer. Thus, it is important to identify the risk factors…

Development of biosensors for detection of alpha-fetoprotein: As a major biomarker for hepatocellular carcinoma

2020

Abstract Alpha-fetoprotein as a multifunctional glycoprotein with a dual regulatory role in cancer and fetal activities is belonging to an albuminoid gene family. Due to important biological activities of alpha-fetoprotein in the adjustment of cancer, the level of this biomarker, majorly in liver carcinomas, abnormally is elevated. Also, the probability of high-risk or low-risk patients for chromosomal abnormalities can be identified by the serum level of alpha-fetoprotein. The detection of biomarkers possesses an important role in prognosis and early diagnosis of cancer and other diseases. So, the development of accurate and sensitive methods for measurement of alpha-fetoprotein is of grea…

Targeting tumor-initiating cells and compensatory YAP pathway to overcome sorafenib resistance in hepatocellular carcinoma

2021

TGFβ-activated kinase 1 (TAK1) is activated and predicts prognosis in hepatocellular carcinoma

2020

Immune pathogenesis of hepatitis A

1992

In an effort to elucidate the mechanism of liver damage resulting from Hepatitis A virus (HAV) infection, we have studied infected skin fibroblasts and autologous lymphocytes from HAV patients. We report here that HLA-restricted virus-specific T cells play an essential role in HAV-related hepatocellular injury.

Editorial: Physiology and Pathophysiology of Heat Shock Protein 60

2020

UNRESECTABLE HEPATOCELLULAR CARCINOMA:META-ANALYSIS OD ARTERIAL EMBOLIZATION

2004

. Radiology. 2002 Jul;224(1):47-54. Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials. Cammà C, Schepis F, Orlando A, Albanese M, Shahied L, Trevisani F, Andreone P, Craxì A, Cottone M. National Council of Research, Istituto Metodologie Diagnostiche Avanzate, Palermo, Italy. camma@ismeda.pa.cnr.it Comment in Radiology. 2003 May;227(2):611-2; author reply 612-3. Radiology. 2004 Jan;230(1):300-1; author reply 301-2. PURPOSE: To review the available evidence of chemoembolization for unresectable hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Computerized bibliographic searches with MEDLINE and CANCERLIT databases fr…