Search results for "Hera"
showing 10 items of 14928 documents
The Role of SVZ Stem Cells in Glioblastoma
2019
As most common primary brain cancer, glioblastoma is also the most aggressive and malignant form of cancer in the adult central nervous system. Glioblastomas are genetic and transcriptional heterogeneous tumors, which in spite of intensive research are poorly understood. Over the years conventional therapies failed to affect a cure, resulting in low survival rates of affected patients. To improve the clinical outcome, an important approach is to identify the cells of origin. One potential source for these are neural stem cells (NSCs) located in the subventricular zone, which is one of two niches in the adult nervous system where NSCs with the capacity of self-renewal and proliferation resid…
Salvage therapy with high-dose cytarabine and mitoxantrone in combination with all-trans retinoic acid and gemtuzumab ozogamicin in acute myeloid leu…
2015
Outcome of patients with primary refractory acute myeloid leukemia remains unsatisfactory. We conducted a prospective phase II clinical trial with gemtuzumab ozogamicin (3 mg/m(2) intravenously on day 1), all-trans retinoic acid (45 mg/m(2) orally on days 4-6 and 15 mg/m(2) orally on days 7-28), high-dose cytarabine (3 g/m(2)/12 h intravenously on days 1-3) and mitoxantrone (12 mg/m(2) intravenously on days 2-3) in 93 patients aged 18-60 years refractory to one cycle of induction therapy. Primary end point of the study was response to therapy; secondary end points included evaluation of toxicities, in particular, rate of sinusoidal obstruction syndrome after allogeneic hematopoietic cell tr…
Multifocal Biliary Cystadenocarcinoma of the Liver: CT and Pathological Findings
2006
Biliary cystadenocarcinoma is a rare tumor that originates from the hepatobiliary epithelium. Although this tumor can affect any portion of the biliary tree, intrahepatic location is more common. It is usually a slow growing tumor and often asymptomatic until it reaches a considerable size. The lesion is most often solitary and large when discovered; multiple lesions or metastases within the liver are very rare. A 63-year-old man was referred to our institute for weight loss, abdominal discomfort, worsening bulky symptoms in the right upper abdominal quadrant, and an increase in serum aminotransferases that had been present for several months. Spiral CT of the abdomen demonstrated two lesi…
Impact of prehospital delay on mortality in patients with acute myocardial infarction treated with primary angioplasty and intravenous thrombolysis.
2001
Abstract Background In patients with acute myocardial infarction treated with thrombolysis, longer times to treatment are associated with increasingly worse clinical outcome. This relation may be different for treatment with primary angioplasty. Methods We analyzed the pooled data of the German acute myocardial infarction registries Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) and Myocardial Infarction Registry (MIR) to determine the influence of prehospital delays on hospital mortality rates. Primary angioplasty was performed in 1063 patients and thrombolysis in 7552 patients. Results In patients treated with thrombolysis, in-hospital time to treatment was constantly 3…
Study of postural control and body balance in subjects with Down syndrome
2020
Purpose. Body imbalance and poor postural control have negative impact on gait and may increase the risk of falling in healthy individuals as well as those with Down syndrome (DS). Since people with DS have lower physical levels than people who do not present this condition, the purpose of our research was to compare features of postural control and body balance between subjects affected by DS and a control sample. Methods. Participants enrolled were divided into the following two groups: A DS group (DSG; n = 22; 9 females and 13 males; age range: 16-36 years) and an age-matched control group (CG; n = 25; 11 females and 14 males; age range: 16-36 years). All participants were subjected to t…
The role of ethnobotanics in scientific research. State of ethnobotanical knowledge in Sicily.
2000
This contribution deals with the traditional use of plants of the Sicilian flora. Special attention is given to the species used in popular medicine. Moreover, the importance of ethnobotanics in scientific research and its role in toxicology are shown.
Safety and efficacy of cervical disc arthroplasty in preventing the adjacent segment disease: a meta-analysis of mid- to long-term outcomes in prospe…
2019
Dariusz Latka,1,2 Klaudia Kozlowska,3 Grzegorz Miekisiak,1,2 Kajetan Latka,2 Jacek Chowaniec,2 Tomasz Olbrycht,2 Miroslaw Latka3 1Department of Anatomy, Institute of Medicine, University of Opole, Opole, Poland; 2Department of Neurosurgery, University Hospital in Opole, Opole, Poland; 3Department of Bioengineering, Institute of Biomedical Engineering, Technical University of Wroclaw, Wroclaw, Poland Objectives: Cervical disc arthroplasty (CDA) has become an alternative treatment for cervical radiculopathy and myelopathy. This technique preserves appropriate motion at both the index and adjacent disc levels and consequently may prevent adjacent segment degeneration (ASD). The authors perform…
Xerostomia induced by radiotherapy: an overview of the physiopathology, clinical evidence, and management of the oral damage
2015
Roberto Pinna,1 Guglielmo Campus,2 Enzo Cumbo,3 Ida Mura,1 Egle Milia2 1Department of Biomedical Science, 2Department of Surgery, Microsurgery and Medicine, University of Sassari, Sassari, 3Department of Dental Science, University of Palermo, Palermo, Italy Background: The irradiation of head and neck cancer (HNC) often causes damage to the salivary glands. The resulting salivary gland hypofunction and xerostomia seriously reduce the patient’s quality of life. Purpose: To analyze the literature of actual management strategies for radiation-induced hypofunction and xerostomia in HNC patients. Methods: MEDLINE/PubMed and the Cochrane Library databases were electronically evaluated f…
La supervisione: strumento di formazione continua per operatori di Comunità Terapeutiche Assistite.
2012
lavoro nelle organizzazioni sociali si presenta oggi complesso e oltremodo denso di criticità. La trasformazione dei quadri di riferimento normativi, la complessità socio-politica e le difficoltà legate agli specifici interventi incidono profondamente sui gruppi di lavoro che o-perano nel sociale, incrementando la già diffusa necessità di essere supportati. Il seguente lavo-ro, a tal fine, terrà fortemente in considerazione la ricchezza e la pluralità dei bisogni che gli operatori del sociale (cooperative, comunità, ecc.) esprimono, rimandando ad un’idea di “cura del loro sviluppo e della loro funzione” complessa e variegata (Basaglia, 1968). È in questa pro-spettiva che lo strumento della …