Search results for "High rate"

showing 10 items of 56 documents

EP46* First pass effect and associated clot characteristics in the EXCELLENT registry – Interim analysis

2021

Introduction EXCELLENT (NCT03685578) is a prospective, single-arm, multicenter, real-world international registry of mechanical thrombectomy (MT) for stroke with the EmboTrap device as first line treatment. The study entails thrombus analysis of specimens collected with each MT pass. Aim of the Study To compare rates of mRS 0–2 at 90 days and clot characteristics in subjects with and without first pass effect (FPE). Methods FPE was defined as mTICI 2c/3 after one pass and non-FPE as mTICI 2c/3 after >1 pass as adjudicated by an independent core lab. Clot analysis was performed by independent central labs blinded to clinical data. mRS at 90 days was scored by investigators blinded to procedu…

Mechanical thrombectomyFirst line treatmentHigh rateFirst pass effectbusiness.industrymedicineOne passThrombusmedicine.diseasebusinessInterim analysisNuclear medicineStrokeESMINT 2021 – Abstract book
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Current and future challenges in HCV: insights from an Italian experts panel

2017

Background: The recent availability of direct acting antiviral drugs (DAAs) has drastically changed hepatitis C virus (HCV) treatment scenarios, due to the exceedingly high rates of sustained virological response (SVR) and excellent tolerability allowing for treatment at all disease stages. Methods: A panel of Italian experts was convened twice, in November 2016 and January 2017, to provide further support on some open issues and provide guidance for personalized HCV care, also in light of forthcoming regimens. Results and conclusions: Treatment recommendations issued by international and national liver societies to guide clinicians in the management of HCV infection are constantly updated …

Microbiology (medical)medicine.medical_specialtySettore MED/17 - Malattie InfettiveDisease stagesComorbidityAntiviral AgentsComorbiditiesVirological response03 medical and health sciences0302 clinical medicineComorbidities; DAAs; HCV; Treatment; Microbiology (medical); Infectious DiseasesmedicineHumans030212 general & internal medicineIntensive care medicineDAAHigh rateComorbidities; DAAs; HCV; Treatmentbusiness.industryDAAsGeneral MedicineHepatitis Cmedicine.diseaseHepatitis CVirologyTreatmentInfectious DiseasesItalyTolerabilityComorbidities; DAAs; HCV; Treatment; Comorbidity; Hepatitis C; Humans; Italy; Antiviral AgentsHealthcare settingsHCV030211 gastroenterology & hepatologyComorbiditiebusinessDirect acting
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Physical Activity Among Children With Congenital Heart Defects in Germany: A Nationwide Survey

2020

Objective: In children with congenital heart defects (CHD), a sedentary lifestyle should be avoided and usually WHO recommendations on physical activity (PA) are supposed to be followed. In order to obtain representative data of the actual amount of PA (and potential influencing factors) in children with CHD we performed a nationwide online survey.Methods: All patients aged 6–17 years registered in the German National Register for CHD were contacted by email and asked to participate in the survey using the comprehensive questionnaire of the “Motorik-Modul” from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS), thus allowing the comparison with a repres…

Pediatricsmedicine.medical_specialtyPhysical activityKind030204 cardiovascular system & hematologyNationwide surveyKörperliche AktivitätMedical carePediatricscongenital heart defect (CHD)Angeborene Krankheitexercise limitation03 medical and health sciences0302 clinical medicineWho recommendationsphysical activities and sportsHeart defects Congenital030225 pediatricsmedicinesurveyddc:610ChildExerciseReference groupSedentary lifestyleOriginal ResearchHigh ratebusiness.industrylcsh:RJ1-570Mean agelcsh:PediatricsHerzfehlerPediatrics Perinatology and Child Healthpediatric cardiologySurveys and questionnairesbusinessFrontiers in Pediatrics
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The MuPix Telescope: A Thin, high Rate Tracking Telescope

2016

The MuPix Telescope is a particle tracking telescope, optimized for tracking low momentum particles and high rates. It is based on the novel High-Voltage Monolithic Active Pixel Sensors (HV-MAPS), designed for the Mu3e tracking detector. The telescope represents a first application of the HV-MAPS technology and also serves as test bed of the Mu3e readout chain. The telescope consists of up to eight layers of the newest prototypes, the MuPix7 sensors, which send data self-triggered via fast serial links to FPGAs, where the data is time-ordered and sent to the PC. A particle hit rate of 1 MHz per layer could be processed. Online tracking is performed with a subset of the incoming data. The ge…

Physics - Instrumentation and DetectorsComputer sciencePhysics::Instrumentation and DetectorsComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISIONFOS: Physical sciencesComputerApplications_COMPUTERSINOTHERSYSTEMSTracking (particle physics)01 natural scienceslaw.inventionTelescopelaw0103 physical sciencesDetectors and Experimental Techniques010306 general physicsField-programmable gate arrayInstrumentationphysics.ins-detMathematical PhysicsHigh ratePixel010308 nuclear & particles physicsbusiness.industryChip architectureDetectorAstrophysics::Instrumentation and Methods for AstrophysicsInstrumentation and Detectors (physics.ins-det)Hit ratebusinessComputer hardware
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Development of an Endcap DIRC for PANDA

2014

Abstract The aim of this research is to develop a planar DIRC detector showing advantages and performance similar to a classical, barrel shaped DIRC, but at smaller polar angles which cannot be accessed using a cylindrical geometry. The device will complement the PANDA Barrel DIRC by covering polar angles from 5° to 22°. The envisaged π /K-separation is ≥ 3 σ up to 4 GeV/c. A major challenge is the adaption of the device to the PANDA environment including a magnetic field of ~1–2 T, high rates and radiation, limited space for optics and sensors as well as the lack of a common first-level trigger. This paper discusses a detector design which forms a compromise between these constraints and a…

PhysicsHigh rateNuclear and High Energy PhysicsPhysics::Instrumentation and Detectorsbusiness.industryDetectorBarrel (horology)Reconstruction methodParticle identificationOpticsPlanarHigh Energy Physics::ExperimentDevelopment (differential geometry)businessInstrumentationCherenkov radiationNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
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Rateless Codes Performance Analysis in Correlated Channel Model for GEO Free Space Optics Downlinks

2012

Settore ING-INF/03 - TelecomunicazioniFree Space Optics (FSO) technologies for satellite communications offer several advantages: wide bandwidth high rate capability immunity to electromagnetic interference and small equipment size. Thus they are suitable for inter-satellite links deep space communications and also for high data rate ground-to-satellite/satellite-to-ground communications. Nevertheless FSO links suffer impairments that cause power signal degradation at the receiver. Scattering and absorption cause power signal attenuations predictable by suitable deterministic models. Optical turbulence causes random irradiance fluctuations which can generate signal fading events and can thereby only be predicted by statistical models. Attenuation and fading events can corrupt FSO links and so it would be recommended to add mitigation error codes on the communication link. FSO channel can be described as an erasure channel: fading events can cause erasure errors. We have identified in rateless codes (RCs) a suitable solution to be employed in FSO links. RCs do not need feedback and they add a redundant coding on the source data that allows the receiver to recover the whole payload despite erasure errors. We implemented two different of rateless codes: Luby Transform (LT) and Raptor. We analyzed their performances on a simulated turbulent GEO FSO downlink (1 Gbps - OOK modulation) at a 106 μm wavelength and for different values of zenith angles. Assuming a plane-wave propagation and employing Hufnagel-Valley we modeled the downlink using: 1) a temporal correlated channel model based on Gamma-Gamma probability distribution and 2) an irradiance covariance function that we converted on a time function using Taylor frozen eddies hypothesis. Our new channel model is able to simulate irradiance fluctuations at different turbulence conditions as it will be shown in the full paper. We will also report performance results of LT and Raptor codes at overhead range varying between 0 and 50% and for different values of source packets.Settore ING-INF/01 - Elettronica
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Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax

2014

The blind mole rat (BMR), Spalax galili, is an excellent model for studying mammalian adaptation to life underground and medical applications. The BMR spends its entire life underground, protecting itself from predators and climatic fluctuations while challenging it with multiple stressors such as darkness, hypoxia, hypercapnia, energetics and high pathonecity. Here we sequence and analyse the BMR genome and transcriptome, highlighting the possible genomic adaptive responses to the underground stressors. Our results show high rates of RNA/DNA editing, reduced chromosome rearrangements, an over-representation of short interspersed elements (SINEs) probably linked to hypoxia tolerance, degene…

SpalaxGeneral Physics and AstronomyZoologyBiologyGenomeGeneral Biochemistry Genetics and Molecular BiologyEvolution MolecularHypercapniaTranscriptome03 medical and health sciences0302 clinical medicineStress PhysiologicalMoleAnimalsHypoxiaSpalax galiliShort Interspersed Nucleotide Elements030304 developmental biologyHigh rate0303 health sciencesGenomeMultidisciplinaryGene Expression ProfilingGeneral ChemistryDarknessbiology.organism_classificationAdaptation PhysiologicalEvolutionary biologySpalaxRNA EditingAdaptationTranscriptome030217 neurology & neurosurgeryNature Communications
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Tufted angiomas in childhood: A series of 9 cases and a literature review

2015

Introduction: Tufted angioma (TA) is a rare benign vascular tumour that mostly appears during infancy or early childhood, although there are cases reported in adults. Clinical presentation and evolution of TA can vary. Histologically, it takes on a classic appearance of vascular tufts (“cannon ball” like appearance). Patients and methods: A retrospective observational study was conducted that included all patients diagnosed with TA at our centre in the last 20 years. Results: A series of 9 cases of tufted angioma in childhood are presented, 77.7% of which were congenital. This represents a frequency higher than previously described. Spontaneous regression was observed in 55.5% of the cases,…

Tufted angiomaHigh ratePediatricsmedicine.medical_specialtyAngioma en penachoTumoración vascular benignabusiness.industryCongénitoRetrospective cohort studymedicine.diseasePediatricsRJ1-570Management of Technology and InnovationBenign Vascular TumormedicinebusinessLóbulos angiomatososAnales de Pediatría (English Edition)
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Burnout syndrome among psychiatric trainees in 22 countries: Risk increased by long working hours, lack of supervision, and psychiatry not being firs…

2016

AbstractBackgroundPostgraduate medical trainees experience high rates of burnout, but evidence regarding psychiatric trainees is missing. We aim to determine burnout rates among psychiatric trainees, and identify individual, educational and work-related factors associated with severe burnout.MethodsIn an online survey psychiatric trainees from 22 countries were asked to complete the Maslach Burnout Inventory (MBI-GS) and provide information on individual, educational and work-related parameters. Linear mixed models were used to predict the MBI-GS scores, and a generalized linear mixed model to predict severe burnout.ResultsThis is the largest study on burnout and training conditions among p…

Working hoursAdultMaleMental Health ServicesComplete datamedicine.medical_specialtyBurnout; Psychiatry; Risk factors; Supervision; Training; Adult; Career Choice; Demography; Education Medical Continuing; Female; Humans; Male; Mental Health Services; Middle Aged; Personality Inventory; Psychiatry; Risk Factors; Socioeconomic Factors; Surveys and Questionnaires; Work Schedule Tolerance; Burnout Professional; Psychiatry and Mental HealthPersonality Inventoryhealth care facilities manpower and servicesBurnout syndromeeducationBurnout03 medical and health sciences0302 clinical medicineRisk FactorsSurveys and QuestionnairesWork Schedule TolerancemedicineHumans030212 general & internal medicinePsychiatryBurnout ProfessionalDemographyHigh rateResponse rate (survey)PsychiatryCareer Choicebusiness.industryMiddle Aged030227 psychiatryPsychiatry and Mental healthSocioeconomic FactorsEducation Medical ContinuingFemalePersonality Assessment Inventorybusinesspsychological phenomena and processesCareer choiceClinical psychologyEuropean psychiatry : the journal of the Association of European Psychiatrists
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A Step into the Future: Applications of Nanoparticle Enzyme Mimics.

2018

We describe elementary concepts, up-to-date developments, and perspectives of the emerging field of nanoparticle enzyme mimics (so-called "nanozymes") at the interface of chemistry, biology, materials, and nanotechnology. The design and synthesis of functional enzyme mimics is a long-standing goal of biomimetic chemistry. Metal complexes, polymers and engineered biomolecules capturing the structure of natural enzymes or their active centers have been made to achieve high rates and enhanced selectivities. Still, the design of new "artificial enzymes" that are not related to proteins but with capacity of production and stability at industrial level, remains a goal. Inorganic nanoparticles bea…

chemistry.chemical_classificationHigh rateBiomoleculeOrganic ChemistryIrregular shapeNanoparticleProteinsNanotechnology02 engineering and technologyGeneral Chemistry010402 general chemistry021001 nanoscience & nanotechnology01 natural sciencesCatalysis0104 chemical sciencesNanomaterialsEnzymesEnzymechemistryBiomimeticsCoordination ComplexesNanoparticlesNanotechnology0210 nano-technologyInorganic nanoparticlesChemistry (Weinheim an der Bergstrasse, Germany)
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