Search results for "Hodgkin"
showing 10 items of 180 documents
Analysis of Metabolic Parameters Coming from Basal and Interim PET in Hodgkin Lymphoma
2018
Objective: Positron Emission Tomography (PET) with F-18-Fluoro-deoxy-glucose (FDG) emerged as a prognostic tool to predict treatment outcome in Hodgkin Lymphoma (HL). Moreover, a FDG-PET adapted strategy is currently assessed in clinical trial to minimize the toxic effect while maintaining the efficacy of treatment in HL. Purpose was to analyze the quantitative parameters to support the prognostic role of FDG-PET today based on the semi-quantitative Deauville 5-point Scale (D5-PS). Methods: This retrospective study included 53 patients diagnosed with advanced-stage HL between 2009 and 2014, enrolled in the PET response-adapted clinical trial HD 0607. FDG-PET was performed at baseline (PET0)…
Human bone marrow mesenchymal stem cells display anti-cancer activity in SCID mice bearing disseminated non-Hodgkin's lymphoma xenografts.
2010
Background Although multimodality treatment can induce high rate of remission in many subtypes of non-Hodgkin's lymphoma (NHL), significant proportions of patients relapse with incurable disease. The effect of human bone marrow (BM) mesenchymal stem cells (MSC) on tumor cell growth is controversial, and no specific information is available on the effect of BM-MSC on NHL. Methodology/Principal Findings The effect of BM-MSC was analyzed in two in vivo models of disseminated non-Hodgkin's lymphomas with an indolent (EBV− Burkitt-type BJAB, median survival = 46 days) and an aggressive (EBV+ B lymphoblastoid SKW6.4, median survival = 27 days) behavior in nude-SCID mice. Intra-peritoneal (i.p.) i…
Pathobiology of Hodgkin Lymphoma
2010
Despite its well-known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics, histogenesis, and possible mechanisms of lymphomagenesis. There is complete consensus on the B-cell derivation of the tumor in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients. The REAL/WHO classification recognizes a basic distinction between lymphocyte predominance HL (LP-HL) and classic HL (cHL), reflecting the differences in clinical presentation and behavior, morphology, phenotype, and molec…
Burkitt’s lymphoma in pregnant woman: Difficult management of a rare case
2020
Highlights • Burkitt’s lymphoma, an aggressive non-Hodgkin lymphoma, is extremely rare during pregnancy. • Lymphoma of the small intestine is often overlooked in the early stages of the disease. • We described a multidisciplinary approach, cesarean section with surgical intestinal exploration.
Topology of multiplex heterogeneous networks of Hodgkin-Huxley-type of models with bistability leading to stabilization stable equilibrium
2021
The dynamics of a multiplex heterogeneous networks of oscillators is studied. Two types of very similar models based on the Hodgkin-Huxley formalism are used as the basic elements of the network: the first one demonstrates bursting oscillations; the second one manifests bistability between bursting oscillations and stable equilibrium. Multiplex networks were developed and investigated, assuming more active communication between models with bistability. Different topologies of the networks are studied. It is shown that in this case it is enough to have one element with bistability in the subnetworks in order to stabilize the equilibrium state in the entire network.
Residential Exposure to PM2.5 Components and Risk of Childhood Non-Hodgkin Lymphoma in Denmark: A Nationwide Register-Based Case-Control Study
2020
In a recent study, we observed an increased risk of childhood non-Hodgkin lymphoma (NHL) associated with exposure to fine atmospheric particulate matter (PM2.5) and black carbon (BC). In this nationwide register-based case-control study, we focus on specific components of PM2.5 in relation to childhood NHL in Denmark (1981&ndash
Non-response bias as a likely cause of the association between young maternal age at the time of delivery and the risk of cancer in the offspring.
2003
Some epidemiological studies have shown an association between young maternal age at the time of delivery and risk of cancer in the offspring. In a recent German case-control study, there was a twofold increase in the leukaemia risk for children whose mothers were aged < 20 years at the time of delivery. As the prevalence of younger mothers among control families was particularly low, data on maternal age distributions for the general population of Germany were obtained in order to examine the representativeness of the control sample. Despite the excellent sampling frame based on data from complete and up-to-date population registries and a satisfactory response rate among controls ( approx…
Ergodicity for a stochastic Hodgkin–Huxley model driven by Ornstein–Uhlenbeck type input
2013
We consider a model describing a neuron and the input it receives from its dendritic tree when this input is a random perturbation of a periodic deterministic signal, driven by an Ornstein-Uhlenbeck process. The neuron itself is modeled by a variant of the classical Hodgkin-Huxley model. Using the existence of an accessible point where the weak Hoermander condition holds and the fact that the coefficients of the system are analytic, we show that the system is non-degenerate. The existence of a Lyapunov function allows to deduce the existence of (at most a finite number of) extremal invariant measures for the process. As a consequence, the complexity of the system is drastically reduced in c…
Therapy response evaluation of malignant lymphoma in a multicenter study: comparison of manual and semiautomatic measurements in CT.
2014
Purpose: Comparison of manual one-/bi-dimensional measurements versus semi-automatically derived one-/bi-dimensional and volumetric measurements for therapy response evaluation of malignant lymphoma during CT follow-up examinations in a multicenter setting. Materials and Methods: MSCT data sets of patients with malignant lymphoma were evaluated before (baseline) and after two cycles of chemotherapy (follow-up) at radiological centers of five university hospitals. The long axis diameter (LAD), the short axis diameter (SAD) and the bi-dimensional WHO of 307 target lymph nodes were measured manually and semi-automatically using dedicated software. Lymph node volumetry was performed semi-automa…
Factors related to the relative survival of patients with diffuse large B-cell lymphoma in a population-based study in France: does socio-economic st…
2017
IF 7.702; International audience; The survival of patients with diffuse large B-cell lymphoma has increased during the last decade as a result of addition of anti-CD20 to anthracycline-based chemotherapy. Although the trend is encouraging, there are persistent differences in survival within and between the USA and European countries suggesting that non-biological factors play a role. Our aim was to investigate the influence of such factors on relative survival of patients with diffuse large B-cell lymphoma. We conducted a retrospective, multicenter, registry-based study in France on 1165 incident cases of diffuse large B-cell lymphoma between 2002 and 2008. Relative survival analyses were p…