6533b86dfe1ef96bd12ca0bd

RESEARCH PRODUCT

Therapy response evaluation of malignant lymphoma in a multicenter study: comparison of manual and semiautomatic measurements in CT.

L. WassenaarVolker DickenD. Pinto Dos SantosM. KarpitschkaRolf M. MestersBoris BuerkeChristoph SchülkeA WulffAnno GraserL. BornemannMelvin D’ AnastasiR. KochM FabelA. J. HöinkN. KohlhaseJ. WeßlingAndreas KiesslingWalter Heindel

subject

ThoraxAdultMalemedicine.medical_specialtyRadiation DosageMalignant lymphomaYoung AdultAntineoplastic Combined Chemotherapy ProtocolsImage Interpretation Computer-AssistedMultidetector Computed TomographyMedicineHumansRadiology Nuclear Medicine and imagingLymph nodeAgedNeoplasm StagingRetrospective StudiesAged 80 and overbusiness.industryLymphoma Non-HodgkinMediastinumRetrospective cohort studyMiddle Agedmedicine.diseaseHodgkin DiseaseLymphomamedicine.anatomical_structureTherapy responseTreatment OutcomeMulticenter studyFemaleRadiologybusiness

description

Purpose: Comparison of manual one-/bi-dimensional measurements versus semi-automatically derived one-/bi-dimensional and volumetric measurements for therapy response evaluation of malignant lymphoma during CT follow-up examinations in a multicenter setting. Materials and Methods: MSCT data sets of patients with malignant lymphoma were evaluated before (baseline) and after two cycles of chemotherapy (follow-up) at radiological centers of five university hospitals. The long axis diameter (LAD), the short axis diameter (SAD) and the bi-dimensional WHO of 307 target lymph nodes were measured manually and semi-automatically using dedicated software. Lymph node volumetry was performed semi-automatically only. The therapeutic response was evaluated according to lymphoma-adapted RECIST. Results: Based on a single lymph node, semi-automatically derived multidimensional parameters allowed for significantly more accurate therapy response classification than the manual or the semi-automatic unidimensional parameters. Incorrect classifications were reduced by up to 9.6 %. Compared to the manual approach, the influence of the study center on correct therapy classification is significantly less relevant when using semi-automatic measurements. Conclusion: Semi-automatic volumetry and bi-dimensional WHO significantly reduce the number of incorrectly classified lymphoma patients by approximately 9.6 % in the multicenter setting in comparison to linear parameters. Semi-automatic quantitative software tools may help to significantly reduce wrong classifications that are associated with the manual assessment approach. Key Points: • Semi-automatic volumetry and bi-dimensional WHO significantly reduce the number of incorrectly classified lymphoma patients • Manual lymph node evaluation with uni-dimensional parameters is inferior to semi-automatic analysis in a multicenter setting • Semi-automatic quantitative software tools should be introduced in clinical study evaluation. Citation Format: • Wesling J, Schulke C, Koch R et al. Therapy Response Evaluation of Malignant Lymphoma in a Multicenter Study: Comparison of Manual and Semiautomatic Measurements in CT. Fortschr Rontgenstr 2014; 186: 768 – 779

yearjournalcountryeditionlanguage
2014-02-04RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
10.1055/s-0033-1356424https://pubmed.ncbi.nlm.nih.gov/24497088