0000000000785257
AUTHOR
Andreas Kiessling
Partial volume correction for volume estimation of liver metastases and lymph nodes in CT scans using spatial subdivision
In oncological therapy monitoring, the estimation of tumor growth from consecutive CT scans is an important aspect in deciding whether the given treatment is adequate for the patient. This can be done by measuring and comparing the volume of a lesion in the scans based on a segmentation. However, simply counting the voxels within the segmentation mask can lead to significant differences in the volume, if the lesion has been segmented slightly differently by various readers or in different scans, due to the limited spatial resolution of CT and due to partial volume effects. We present a novel algorithm for measuring the volume of liver metastases and lymph nodes which considers partial volum…
Therapy response evaluation of malignant lymphoma in a multicenter study: comparison of manual and semiautomatic measurements in CT.
Purpose: Comparison of manual one-/bi-dimensional measurements versus semi-automatically derived one-/bi-dimensional and volumetric measurements for therapy response evaluation of malignant lymphoma during CT follow-up examinations in a multicenter setting. Materials and Methods: MSCT data sets of patients with malignant lymphoma were evaluated before (baseline) and after two cycles of chemotherapy (follow-up) at radiological centers of five university hospitals. The long axis diameter (LAD), the short axis diameter (SAD) and the bi-dimensional WHO of 307 target lymph nodes were measured manually and semi-automatically using dedicated software. Lymph node volumetry was performed semi-automa…