Search results for "Hom"
showing 10 items of 8335 documents
Identification of the Yersinia enterocolitica urease beta subunit as a target antigen for human synovial T lymphocytes in reactive arthritis.
1993
The local T-cell response to bacterial antigens is involved in the pathogenesis of reactive arthritis (ReA). Here, we have identified a 19-kDa antigen of Yersinia enterocolitica O:9 recognized by Yersinia-specific synovial fluid CD4+ T cells in two patients with Yersinia-induced ReA. N-terminal amino acid sequencing of this protein revealed that it was identical to the 19-kDa urease beta subunit of Y. enterocolitica O:9. This protein has previously been shown to be arthritogenic in preimmunized rats after intra-articular injection. Analysis of the T-cell response to this protein showed that it contains several T-cell epitopes, one of which cross-reacts with other enterobacteria not able to …
Sequence analysis of the DRB1 promoter reveals limited polymorphism with no influence on gene expression.
2001
HLA-class II promoters contain a set of conserved regulatory regions necessary for constitutive and induced gene expression. For the HLA-DQB as well as for the DRB1 promoter sequence, polymorphisms with influence on gene expression have been reported. In contrast to these data we could show that there is very limited allele-specific polymorphism among the HLA-DRB1 promoter alleles. In a long range PCR we amplified a DNA sequence containing the promoter and the second exon of the DRB1 gene in one fragment. Nested PCR products of this PCR fragment for the promoter and for the second exon were analysed by DNA sequencing to allow the linkage of a promoter to its DR allele. Most investigated DRB…
A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA b…
2002
The Cockayne syndrome B (CSB) gene product is involved in the repair of various types of base modifications in actively transcribed DNA sequences. To investigate its significance for the repair of endogenous oxidative DNA damage, homozygous csb(-/-)/ogg1(-/-) double knockout mice were generated. These combine the deficiency of CSB with that of OGG1, a gene coding for the mammalian repair glycosylase that initiates the base excision repair of 7,8-dihydro-8-oxoguanine (8-oxoG). Compared to ogg1(-/-) mice, csb(-/-)/ogg1(-/-) mice were found to accumulate with age severalfold higher levels of oxidited purine modifications in hepatocytes, splenocytes and kidney cells. In contrast, the basal (ste…
Novel Digital Technique to Quantify the Area and Volume of Cement Remaining and Enamel Removed after Fixed Multibracket Appliance Therapy Debonding: …
2020
The aim of this study was to construct a novel, repeatable, reproducible, and accurate measurement protocol for the area and volume of the remaining cement after removal of fixed multibracket appliances, the area and volume of remaining cement after cement removal, the area and volume of enamel removed after cement removal, and the volume of cement used to adhere fixed multibracket appliances. A total of 30 brackets were cemented and removed with over 30 extracted teeth embedded into three experimental models of epoxy resin. The models were scanned before and after bracket placement, bracket debonding, and polishing the remaining cement. The brackets were submitted to micro-computed tomogra…
MINIMIZING INFLIXIMAB TOXICITY IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE
2008
Abstract Background Infliximab is a widely used biological agent for the treatment of inflammatory bowel disease, and has a favorable risk/benefit ratio. Aim It is useful to know that patients treated with infliximab are exposed to developing adverse events that could be reduced with a prudent and a rational clinical approach and by optimizing the treatment protocol. Methods PubMed (including Epub) was searched in October 2006 and again in March 2007. Results The high immunogenic potential of infliximab determines the antibodies that inhibit the effect of infliximab and the appearance of subsequent acute and delayed infusion reactions. Infliximab has an immunomodulatory effect, thus increas…
Systematic Use of Song and Music in Dementia Care: Health Care Providers’ Experiences
2020
Background and Aim Using song and music in a systematic way in residential dementia care may have several positive impacts on the patients, as well as the care providers. The aim of this study was to explore how health care providers experienced taking responsibility for conducting a song and music program in dementia care in nursing homes. Methods An explorative, qualitative study design was used. Focus groups were formed by 17 health care providers from 3 different nursing homes. These providers had experience implementing and using the “Gjenklang” (“reverberation”) song and music program especially developed for people with dementia. Focus group interviews were transcribed verbatim, and …
Bringing madness home : the multiple meanings of home in Janet Frame's Faces in the water, Bessie Head's A question of power and Lauren Slater's Proz…
2012
Tarina, joka on koettava : narratiivisten tutkimispelien taustat, tarinat ja kerronta
2015
Pro gradu -työssäni tutkin narratiivisia tutkimispelejä, joka on uusi ja vasta vähän tutkittu digitaalisten pelien genre. Tutkielmani on muodoltaan artikkeligradu, joka koostuu kolmesta artikkelista sekä Johdanto- ja Yhteenveto-luvuista. Ensimmäisessä artikkelissa esittelen narratiivisten tutkimispelien genreä, sen taustaa ja tärkempiä genreen kuuluvia pelejä. Lisäksi luon määritelmän narratiivisten tutkimispelien genrelle osoittamalla yhteisiä ominaispiirteitä kahdeksasta pelistä, joiden katson edustavan kyseistä genreä. Tarkastelemani narratiiviset tutkimispelit ovat kaikki uusia, vuosina 2012–2015 ilmestyneitä, lukuun ottamatta vuonna 1993 ilmestynyttä klassikkopeliä Myst, joka voidaan n…
Narratives by women managers about spousal support for their careers
2014
In this article we present a qualitative study of spousal support for the careers of women managers. The research material consists of the narratives of 25 women managers in Finland. The study has two main implications. Firstly, unlike previous studies, we use a narrative approach to demonstrate that a woman manager's career and spousal support are experienced as ambiguous and evolving over the career. The support was constructed by the women managers as flourishing, irrelevant, deficient or inconsistent. Secondly, to increase our knowledge about gender relations, we combine discussion of the topic with gender order analysis and suggest that gender order is critical for an understanding of …
Anwendungsbezogene Transformationen antiker Literatur im Neuhumanismus und in unmittelbarer Zeitgegenwart. Ausstellungspraktische und jugenddidaktisc…
2017
Właśnie w czasach oszczędności finansowych oraz postępującego procesu ekonomizacji kultury jest ważnym fakt, aby filolodzy angażowali się również kulturowo i politycznie dla swoich autorów, nad którymi sprawują opiekę naukową, oraz w zakresie tematyki dzieł. Artykuł opisuje przygotowywaną wystawę w Domu Literatury im. Johann-Heinrich-Voß'a w Penzlin, w miejscowości, w której Voß otrzymał pierwsze impulsy rozwoju. Voß wyjaśnia propozycje szkolno-pedagogiczne, w pewnym sensie skromne warsztaty literackie, które zostaną zrealizowane w ramach wystawy stałej zatytułowanej "Johann Heinrich Voß. Grek z Mecklenburii".