Search results for "Horizon"

Las campañas de excavación de 2010 y 2011 en el yacimiento neolítico del Mas d’Is (Penàguila, Alacant)

2011

Las campañas de 2010 y 2011 en el yacimiento Neolítico del Mas d’Is han venido a complementar los numerosos datos conocidos hasta la actualidad. En las mismas se ha podido documentar ampliamente la morfología de las estructuras que veníamos interpretando como fosos, por un lado; y, por otro, se ha avanzado en el conocimiento de la secuencia cronocultural del yacimiento al encontrar episodios que hasta el momento estaban pocos representados.

Extracellular Membrane Vesicles as Vehicles for Brain Cell-to-Cell Interactions in Physiological as well as Pathological Conditions.

2015

Extracellular vesicles are involved in a great variety of physiological events occurring in the nervous system, such as cross talk among neurons and glial cells in synapse development and function, integrated neuronal plasticity, neuronal-glial metabolic exchanges, and synthesis and dynamic renewal of myelin. Many of these EV-mediated processes depend on the exchange of proteins, mRNAs, and noncoding RNAs, including miRNAs, which occurs among glial and neuronal cells. In addition, production and exchange of EVs can be modified under pathological conditions, such as brain cancer and neurodegeneration. Like other cancer cells, brain tumours can use EVs to secrete factors, which allow escaping…

Nanomaterial-based electrochemical immunosensors as advanced diagnostic tools

2014

A literature survey has been made of recent advances in the use of new nanomaterials for the biosensing of different biomolecules, which have opened new horizons in identifying and quantifying biomolecules, for possible early diagnosis of disease. Nanomaterials show similar dimensions to biomolecules like proteins (enzymes, antigens and antibodies) and DNA. The integration of nanomaterials with biomaterials results in novel hybrid nanobiomaterials with synergetic properties and functions. In this review, we will discuss recent progress in the field, describing the basic concepts of nanomaterial-based platforms for development and expansion of immunosensors and nanosensors. We present an ove…

2021

Aging and diabetes lead to protein glycation and cause dysfunction of collagen-containing tissues. The accompanying structural and functional changes of collagen significantly contribute to the development of various pathological malformations affecting the skin, blood vessels, and nerves, causing a number of complications, increasing disability risks and threat to life. In fact, no methods of non-invasive assessment of glycation and associated metabolic processes in biotissues or prediction of possible skin complications, e.g., ulcers, currently exist for endocrinologists and clinical diagnosis. In this publication, utilizing emerging photonics-based technology, innovative solutions in mac…

Optical and electrochemical DNA nanobiosensors

2011

In the past two decades, nanoscale advanced materials have been explored for biosensing molecules, so new horizons have opened up for identifying and quantifying biomolecules, and possible early diagnosis of diseases. DNA nanobiosensors show promise. This article provides an overview on their optical and electrochemical aspects. We discuss recent progress in this field, describing basic concepts of molecular beacons and quantum dots as optical nano-imaging systems. Also, carbon nanotubes provide a platform for development and advancement of electrochemical DNA nanobiosensors, which are increasingly being implemented as robust tools for detection in biomedical sciences. Refereed/Peer-reviewed

Determining the optimal maximal and submaximal voluntary contraction tests for normalizing the erector spinae muscles

2019

Background This study aimed to identify which maximum voluntary isometric contraction (MVIC) and sub-MVIC tests produce the highest activation of the erector spinae muscles and the greatest reduction in inter-individual variability, to put them forward as reference normalization maneuvers for future studies. Methods Erector spinae EMG activity was recorded in 38 healthy women during five submaximal and three maximal exercises. Results None of the three MVIC tests generated the maximal activation level in all the participants. The maximal activation level was achieved in 68.4% of cases with the test performed on the roman chair in the horizontal position (96.3 ± 7.3; p < 0.01). Of the fi…

Better the devil you know? Guidelines for insightful utilization of nrDNA ITS in species-level evolutionary studies in plants.

2006

The internal transcribed spacers (ITS) of the nuclear ribosomal 18S–5.8S–26S cistron continue to be the most popular non-plastid region for species-level phylogenetic studies of plant groups despite the early warnings about their potential Xaws, which may ultimately result in incorrect assumptions of orthology. It has been gradually realized that the alternative target regions in the nuclear genome (lowcopy nuclear genes, LCNG) are burdened with similar problems. The consequence is that, to date, developing useful LCNG for nonmodel organisms requires an investment in time and eVort that hinders its use as a real practical alternative for many labs. It is here argued that ITS sequences, desp…

Horizon Europe, the new programme for research & innovation: Which opportunities for GI research in the years to come?

2021

Optimal Management of Human Resources in Transhipment Container Ports

2014

Human resources allocation plays a key role in Transhipment Maritime Container Terminals to achieve high levels of productivity and provide high quality services to shipping companies. The deep interest of container terminals in this issue can be supported by optimization methods. In this work, an optimization model is proposed to determine the optimal daily allocation of crane operators and trailer drivers. Different requirements are taken into account for permanent staff, external workers and personnel shortfall. Since workforce undermanning is a crucial factor for both shipping companies and container terminals, we aim to show that personnel shortfalls and operation delays can be signifi…

Rapid and specific detection of F17-related pilin and adhesin genes in diarrheic and septicemic Escherichia coli strains by multiplex PCR

1996

The F17-related adhesins are prevalent in Escherichia coli strains isolated from calves with diarrhea or septicemia and from lambs with nephropathy. The F17 family includes the F17a, F17b, F17c, and F111 fimbriae produced by bovine E. coli strains and the G agglutinin produced by human uropathogenic E. coli strains. An easy and inexpensive multiplex PCR method was developed to detect all the F17-related fimbriae and to identify four subtypes of structural subunit genes and two distinct subfamilies of adhesin genes by only two runs of amplification. A strict correlation was observed between the phenotypic assays and the multiplex PCR method when 166 pathogenic E. coli strains isolated from i…