Search results for "Hormonal"

Extracellular vesicles and high‐density lipoproteins: Exercise and oestrogen‐responsive small RNA carriers

2023

Decreased systemic oestrogen levels (i.e., menopause) affect metabolic health. However, the detailed mechanisms underlying this process remain unclear. Both oestrogens and exercise have been shown to improve metabolic health, which may be partly mediated by circulating microRNA (c-miR) signalling. In recent years, extracellular vesicles (EV) have increased interest in the field of tissue crosstalk. However, in many studies on EV-carried miRs, the co-isolation of high-density lipoprotein (HDL) particles with EVs has not been considered, potentially affecting the results. Here, we demonstrate that EV and HDL particles have distinct small RNA (sRNA) content, including both host and nonhost sRN…

Influence of Menstrual Cycle or Hormonal Contraceptive Phase on Physiological Variables Monitored During Treadmill Testing

2021

Purpose: To examine the influence of menstrual cycle (MC) and hormonal contraceptive (HC) cycle phases on physiological variables monitored during incremental treadmill testing in physically active women (eumenorrheic, EUM = 16 and monophasic HC-users, CHC = 12). Methods: Four running tests to exhaustion were performed at bleeding, mid follicular (mid FOL)/active 1, ovulation/active 2, and mid luteal (mid LUT)/inactive. HC and MC phases were confirmed from serum hormones. Heart rate (HR), blood lactate (Bla), and VO˙ 2 were monitored, while aerobic (AerT) and anaerobic (AnaT) thresholds were determined. VO˙ 2peak, maximal running speed (RUNpeak), and total running time (RUNtotal) were recor…

Predicting the age at natural menopause in middle-aged women

2021

Objective To predict the age at natural menopause (ANM). Methods Cox models with time-dependent covariates were utilized for ANM prediction using longitudinal data from 47 to 55-year-old women (n = 279) participating in the Estrogenic Regulation of Muscle Apoptosis study. The ANM was assessed retrospectively for 105 women using bleeding diaries. The predictors were chosen from the set of 32 covariates by using the lasso regression (model 1). Another easy-to-access model (model 2) was created by using a subset of 16 self-reported covariates. The predictive performance was quantified with c-indices and by studying the means and standard deviations of absolute errors (MAE ± SD) between the pre…

Znaczenie prenatalnego okresu życia dla rozwoju tożsamości płciowej

2022

Płeć możemy różnicować na podstawie płci genetycznej, gonadalnej, genitalnej i hormonalnej, odmiennych zachowań kobiety i mężczyzny, różnic w budowie ciała oraz narządów płciowych, tego, czy dany osobnik czuje się kobietą czy mężczyzną. Niniejszy artykuł jest jedynie próbą spojrzenia na płeć ludzką z kilku perspektyw. Próbą pokazania kształtowania się płci oraz czynników, które mogą zaburzyć ten proces.

Temes Bioquímica I, Grau de Nutrició Humana i Dietètica, UVEG

2019

El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València Temes de la assignatura de Bioquímica I del Grau de Nutrició Humana i Dietètica. Inclou una introducció a les vies metaboliques i la seua regulació hormonal i una descripció de les vies metaboliques que permeten obtindre energia a partir de la glucosa (glucòlisi, oxidació del piruvat, cicle de Krebs, transport electrònic i fosforilació oxidativa) Different subjects of Biochemistry I, a basic subject of the Degree in Human Nutrition and Dietetics. It includes an introduction to metabolic pathways and their hormonal regulation and a description of the met…

Serum hormone concentrations and physical performance during concurrent strength and endurance training in recreational male and female endurance run…

2011

To investigate the effects of concurrent strength and endurance training on physical performance and serum hormone levels a total of 32 recreational endurance runners were trained for 18 weeks. Subjects were divided into four training groups separated by the strength training mode and gender. The groups were women’s and men’s combined maximal and explosive strength training group (WME; n=9 and MME; n=9), and women’s and men’s muscle endurance strength training group (WE; n= 8 & ME; n=8). The training was executed in three consecutive periods (I; 10 weeks, II; 4 weeks and III; 4 weeks). The endurance training in all groups was low-intensity (below lactate threshold) running throughout the wh…

Steroid Receptor Expression in Endometria from Women Treated with Tamoxifen

1998

Abstract Breast cancer patients receiving tamoxifen (Tam) are at an increased risk for developing endometrial carcinomas, possibly due to the partial estrogenic effect of Tam on endometrial cells. Progestational therapy has not routinely been included in Tam regimens. It was our aim to determine the presence of estrogen receptors (ERs) and progesterone receptors (PRs) in normal and abnormal endometria from postmenopausal women with breast cancer who were treated with Tam. Standard immunohistochemical staining of ERs and PRs was performed on paraffin sections from formalin-fixed uterine curettings or hysterectomy specimens from 40 patients who had received 20–40 mg of Tam daily for a minimum…

The Patient's Anastrozole Compliance to Therapy (PACT) Program: a randomized, in-practice study on the impact of a standardized information program o…

2013

BACKGROUND Compliance and persistence are often overlooked in adjuvant breast cancer treatment. PATIENTS AND METHODS PACT was a prospective, multicenter, randomized, open, parallel-group study assessing whether educational materials (EMs) enhanced compliance with aromatase inhibitor (AI) therapy in postmenopausal women with early, hormone-receptor-positive (HR+) breast cancer. The primary end points were compliance (proportion taking ≥ 80% anastrozole) at 12 months and persistence (proportion reporting anastrozole intake during the study period). RESULTS Four thousand eight hundred and forty-four patients were randomly assigned 1:1 to receive standard therapy or standard therapy with EMs. T…

Mutations in the Factor XII Gene in Solitary Cases of Recurrent Angioedema with Normal C1 Inhibitor Induced or Worsened by Oral Contraceptives or Hor…

2012

Correlates of hormone replacement therapy use in Italian women, 1992-1996

1999

we analyzed the determinants of hormonal replacement therapy (HRT) use in Italy for the period 1992-1996, using data from a framework of case-control studies of colon and rectal neoplasm.a total of 1574 women aged 45-74 years were considered. This group comprised women with acute, non neoplastic, non-hormone-related diseases admitted to a network of hospitals in six areas of Italy.a total of 146 women (8.5%) reported ever HRT use. The multivariate odds ratio (OR) of ever use was 1.6 (95% CI 1.0-2.6) for women with 12 years of education or more, compared with those with7 years. The frequency of use of HRT tended to decrease with increasing parity: the OR was 0.6 for women with four or more c…