Search results for "Hsp"

Korpora, Kombinatorik, Übersetzungssegmente… statt Terminologie? Zum neuen Stellenwert von Termini und Terminologie im Sprachtechnologie-Zeitalter am…

2021

International audience; Kontext Fachübersetzung sieht sich heute – vor dem Hintergrund der rasanten Entwicklung von Sprachtechnologien – vor neue Herausforderungen gestellt. Korpusbasierte Tools und Systeme wie Translation Memories, Konkordanzen, Maschinenübersetzung, … lenken die Aufmerksamkeit auf neue Übersetzungseinheiten, die – meistens als „Segmente“ aufgefasst – die traditionellen am Sprachsystem orientierten Kategorien – allen voran das Wort – neu beleuchten. Als auf die mehr oder weniger gelenkte Vermittlung von Fachinhalten ausgerichtete Tätigkeit bleibt aber Fachübersetzung nach wie vor sehr stark von terminologischen Fragestellungen geprägt, da das dem zu übersetzenden Text zu…

Fachsprachliche Konstruktionen? Zur korpuslinguistischen Neufundierung des Lexik-Grammatik-Kontinuums in stark formalisierten Fachtextsorten

2017

International audience; [Problemstellung und Thesen] Folgender Vorschlag reiht sich hauptsächlich in den ersten thematischen Strang des Calls für die Sektion ‚Grammatik und Grammatikographie’ ein, wobei die Forschungsergebnisse auch didaktisch, also für die „Entwicklung und Erstellung von Lernergrammatiken“ (2. Strang), verwertet werden können. Er geht der Frage nach dem Mehrwert korpuslinguistischer Instrumentarien für die Analyse von Fachtexten mit hohem Grad an Formelhaftigkeit nach. Der Beitrag vertritt folgende Thesen:a.Sind die linguistischen – auch morpho-syntaktischen – Merkmale von Fachtexten nicht qualitativer, sondern quantitativer Natur (Roelcke 20103), so können sie so gut wie …

The cyclopentenone-type prostaglandin 15-deoxy-delta12,14-prostaglandin J2 inhibits CD95 ligand gene expression in T lymphocytes: interference with p…

2003

Abstract 15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone-type PG endowed with anti-inflammatory properties and produced by different cells, including those of the immune system. 15d-PGJ2 is a natural ligand of the peroxisome proliferator-activated receptor (PPAR)-γ nuclear receptor, but relevant PPARγ-independent actions mediated by this prostanoid have been described. Fas (APO-1/CD95) and its ligand (Fas-L) are cell surface proteins whose interaction activates apoptosis of Fas-expressing targets. In T cells, the Fas-Fas-L system regulates activation-induced cell death and has been implicated in diseases in which lymphocyte homeostasis is compromised. Moreover, several studies have desc…

In-Gel Assay to Evaluate Antioxidant Enzyme Response to Silver Nitrate and Silver Nanoparticles in Marine Bivalve Tissues

2022

Silver is back in vogue today as this metal is used in the form of nanomaterials in numerous commercial products. We have developed in-gel electrophoretic techniques to measure the activity of the antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPX), and used the same techniques in combination with HSP70 Western blot analysis to evaluate the effects of nanomolar amounts of silver nitrate and 5 nm alkane-coated silver nanoparticles in tissues of the marine bivalve Mytilus galloprovincialis (Lam.) exposed for 28 days in mesocosms. Our results showed a negligible effect for nanosilver exposure and dose-dependent effects for the nitrate form.

Cell Wall and Secreted Proteins ofCandida albicans: Identification, Function, and Expression

1998

SUMMARYThe cell wall is essential to nearly every aspect of the biology and pathogenicity of Candida albicans. Although it was intially considered an almost inert cellular structure that protected the protoplast against osmotic offense, more recent studies have demonstrated that it is a dynamic organelle. The major components of the cell wall are glucan and chitin, which are associated with structural rigidity, and mannoproteins. The protein component, including both mannoprotein and nonmannoproteins, comprises some 40 or more moieties. Wall proteins may differ in their expression, secretion, or topological location within the wall structure. Proteins may be modified by glycosylation (prima…

VEGFR-2, HSP90 and GRP78/BiP expression and HCC recurrence after Liver Transplantation

2018

Introduction Liver transplantation (LT) for hepatocellular carcinoma (HCC) is a satisfactory therapeutic choice in patients with “early HCC” selected according to Milan criteria. However, the risk of HCC recurrence after LT is about 7-20% at five years and molecular markers which can predict recurrence are still lacking. We investigated in HCC samples and LC surrounding tissues the significance of VEGFR-2, HSP90, and GRP78/BiP expression in patients with HCC who underwent LT in a western transplantation center and their possible role as molecular markers of recurrence. Methods 42 patients (35 M, 7 F) with early HCC who underwent LT between 2012 and 2013 were enrolled. The tumor recurrence r…

Hsp70 is required for optimal cell proliferation in mouse A6 mesoangioblast stem cells.

2009

Mouse Hsp70 (70 kDa heat shock protein) is preferentially induced by heat or stress stimuli. We previously found that Hsp70 is constitutively expressed in A6 mouse mesoangioblast stem cells, but its possible role in these cells and the control of its basal transcription remained unexplored. Here we report that in the absence of stress, Ku factor is able to bind the HSE (heat shock element) consensus sequence in vitro, and in vivo it is bound to the proximal hsp70 promoter. In addition, we show that constitutive hsp70 transcription depends on the co-operative interaction of different factors such as Sp1 (specificity protein 1) and GAGA-binding protein with Ku factor, which binds the HSE cons…

Genetic analysis of heat shock response in three Drosophila species of the obscura group

1992

Heat shock response was investigated in three species of the obscura group of the Drosophila genus (D. subobscura, D. guanche, and D. madeirensis) by chromosome cytology analysis and [3H]uridine labeling. A set of eight puffs (2C, 15DE, 18C, 27A, 31CD, 85AB, 89A, and 94A) were induced after heat treatments in each of the three species; 18C, 27A, 89A, and 94A were the most heavily labeled in the autoradiograms after the induced conditions. From the in situ results using the major heat shock genes of D. melanogaster as a probe, it was inferred that the 18C, 94A, 89A, and 27A loci of the three obscura group species are homologous to D. melanogaster loci, which contain, HSP82, HSP70, HSP68, an…

Genetic and phenotypic heterogeneity in two novel cases of Waardenburg syndrome type IV.

2009

Hsp90 dictates viral sequence space by balancing the evolutionary tradeoffs between protein stability, aggregation and translation rate

2017

AbstractAcquisition of mutations is central to evolution but the detrimental effects of most mutations on protein folding and stability limit protein evolvability. Molecular chaperones, which suppress aggregation and facilitate polypeptide folding, are proposed to promote sequence diversification by buffering destabilizing mutations. However, whether and how chaperones directly control protein evolution remains poorly understood. Here, we examine the effect of reducing the activity of the key eukaryotic chaperone Hsp90 on poliovirus evolution. Contrary to predictions of a buffering model, inhibiting Hsp90 increases population sequence diversity and promotes accumulation of mutations reducin…