Search results for "Human papillomaviru"
showing 10 items of 99 documents
Comprehensive Analysis of VEGFR2 Expression in HPV-Positive and -Negative OPSCC Reveals Differing VEGFR2 Expression Patterns
2021
VEGF signaling regulated by the vascular endothelial growth factor receptor 2 (VEGFR2) plays a decisive role in tumor angiogenesis, initiation and progression in several tumors including HNSCC. However, the impact of HPV-status on the expression of VEGFR2 in OPSCC has not yet been investigated, although HPV oncoproteins E6 and E7 induce VEGF-expression. In a series of 56 OPSCC with known HPV-status, VEGFR2 expression patterns were analyzed both in blood vessels from tumor-free and tumor-containing regions and within tumor cells by immunohistochemistry using densitometry. Differences in subcellular colocalization of VEGFR2 with endothelial, tumor and stem cell markers were determined by doub…
Author response: ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly
2019
Infezione orale da Human papillomavirus: dalla verruca al carcinoma orale. Epidemiologia, clinica, prevenzione e terapia
2015
Riasunto Obiettivi Prendere in esame l’epidemiologia e le manifestazioni cliniche dell’infezione orale da Human papillomavirus (HPV), con particolare attenzione alle lesioni con potenziale oncologico maligno. Materiali e metodi E stata condotta una revisione sistematica della letteratura finalizzata a descrivere lo stato dell’arte in merito all’infezione da HPV nella mucosa orofaringea e alle relative modalita di trasmissione del virus con particolare riferimento alla possibile contemporanea infezione in sedi anatomiche multiple. Vengono approfonditi gli aspetti riguardanti la prevenzione e il controllo dell’infezione mediante la somministrazione di vaccini e lo svolgimento di campagne cono…
976Screening for cervical cancer with Human Papillomavirus testing: stand-alone is preferable over co-testing with cytology
2021
Abstract Background Cervical cancer screening can be conducted with cytology and Human Papillomavirus (HPV) testing but few studies have compared the latter directly to concomitant testing (co-testing). We compared these strategies to determine appropriate screening. Methods Within a randomised population-based cohort study conducted around Mainz, Germany, eligible women (≥30 years) were screened via Pap smear, liquid-based cytology (LBC) and HPV testing (HC2) and HPV genotyped post hoc (PCR). These tests formed three strategies: cytology (Pap or LBC) and HPV (HC2 or PCR) stand-alone and co-testing. Screen positives and 5% negative women were invited to colposcopy. Absolute and relative sen…
Socioeconomic factors and cervical cancer mortality in Spain during the period 1989?1997
2002
A study was made of cervical cancer (CC) mortality trends in Spain during the period 1989–1997 at National, Autonomous Community and Provincial levels, in relation to different socioeconomic factors. Data were obtained from the Spanish National Institute of Statistics (Instituto Nacional de Estadistica, INE). The crude mortality rates were age-adjusted using the indirect method and Gross Domestic Product (GDP) as socioeconomic status (SES) indicator. National CC age-adjusted mortality rates have increasing slightly, varying from 3.09 deaths/100,000 women in 1989 to 3.42 in 1996. The highest age-adjusted mortality rates corresponded to Seville, Palencia and Orense, with 4.13, 4.06 and 3.98 c…
The endocytic trafficking pathway of oncogenic papillomaviruses
2019
Over the last two decades many host cell proteins have been described to be involved in the process of infectious entry of oncogenic human papillomaviruses (HPV). After initial binding and priming of the capsid, a sequence of events on the cell surface precedes the formation of the HPV entry platform. It has been shown that the virus-associated entry complex consists of membrane organizers, tetraspanins CD151 and CD63, and their associated partner proteins such as integrins, growth factor receptors, and the annexin A2 heterotetramer. Further recruitment of cytoplasmic factors such as the obscurin-like protein 1 and actin results in a non-canonical clathrin-independent endocytosis of the vir…
Veränderung von Inzidenz und Mortalität von Kopf-Hals-Malignomen in Rheinland-Pfalz, 2000–2009
2014
Hintergrund: Epidemiologische Daten zu Kopf-Hals-Malignomen werden trotz ihrer anatomisch-histologischen Heterogenitat oft aggregiert berichtet. In Deutschland gibt es bisher nur wenige Studien, die Trends von Inzidenz und Mortalitat detailliert nach Tumorentitaten analysiert haben. Weiterhin ist wenig daruber bekannt, ob die Inzidenz von HPV-assoziierten Tumorentitaten der Kopf-Hals-Region zugenommen hat. Methoden: Anhand von Krebsregisterdaten aus Rheinland-Pfalz von 2000–2009 wurden altersstandardisierte Inzidenz- und Mortalitatsraten fur alle Kopf-Hals-Tumorentitaten einzeln und nach Lokalisationsgruppen, die HPV-assoziiert sein konnten, berechnet. Zeitliche Trends wurden mittels Joinpo…
Microbiota e HPV nel carcinoma orale
2021
La carcinogenesi è un processo multifattoriale in cui sono coinvolti differenti fattori esogeni; tra questi, il microbiota sembra svolgere un ruolo attivo nei mec- canismi di sviluppo del carcinoma orale [1]. Nella presente trattazione saranno descritti i principali aspetti epidemiologici, clinici e patogenetici che vedono coinvolto il microbiota orale nel processo di carcinogenesi omodistrettuale. A tal proposito, per facilità di trattazione, è stata condotta una distinzione del microbiota orale in due gruppi: microbiota orale batterico e microbiota orale non batterico (i.e. Candida spp, Human Papilloma Virus). Fra i microrganismi appartenenti a quest’ultimo gruppo, verrà condotta una disa…
Human papillomavirus-associated cancers: a survey on otorhinolaryngologists' knowledge and attitudes on prevention.
2016
Human papillomavirus (HPV) infection is a recognised causal factor associated with oropharyngeal cancers. The global burden of HPVrelated oropharyngeal cancers is on the increase and is predicted to surpass the burden of cervical cancer in the near future. As evidence is accumulating on the potential effectiveness of an HPV vaccine in controlling the oropharyngeal cancer epidemic; otorhinolaryngologists assume a key role - not only in the diagnosis and treatment of HPV-related cancers - but also in educating and advocating on HPV prevention. We conducted a survey to assess Italian otorhinolaryngologists' knowledge and attitudes regarding HPV infection, HPV-related oropharyngeal diseases and…
Factors Associated with HPV Vaccine Refusal among Young Adult Women after Ten Years of Vaccine Implementation
2018
In Italy, the Human Papillomavirus (HPV) vaccination was implemented for twelve years old girls in 2007, but its coverage was lower than the recommended level. Sicily is one of the Italian administrative regions with lower vaccination coverage, with a value of 59% for those born in 1996 increasing to 62% coverage for those born in 1999. The aim of the study was to investigate factors associated with the refusal of HPV vaccination among young adult women of Palermo, Italy. The study was approved by the Ethics Committee of the Policlinico “Paolo Giaccone” Hospital (Palermo 1) and the questionnaire was validated in a convenience sample representing 10% of the young women. A cross-s…