Search results for "Humor"
showing 10 items of 220 documents
Estrategias de afrontamiento de profesionales que atienden a la infancia y adolescencia con necesidades de apoyo: una aproximación desde la ética del…
2021
Marco teórico. El presente trabajo de investigación aborda en su marco teórico el concepto de discapacidad y cómo éste ha ido cambiando a lo largo del tiempo desde un enfoque centrado en la discapacidad hasta un modelo centrado en la persona. Más adelante analiza la salud y la calidad de vida de los/as profesionales que atienden a niños/as y adolescentes con necesidades de apoyo, así como los factores que pueden repercutir en la sensación de estar quemado/a en el trabajo, cuestión que se deriva del estrés laboral, el burnout o la fatiga por compasión. A continuación pone el foco en las distintas estrategias que utilizan estos/as profesionales y, entre ellas, el humor ético. Para finalizar, …
Humors starpkultūru darījumu saziņā
2018
Humoram ir liela nozīme ikdienas komunikācijā. Ņemot vērā to, ka cilvēki lielu daļu no dzīves pavada darbavietās, autors nolēma pievērst uzmanību humora lomai starpkultūru uzņēmējdarbības saziņā. Tāpēc šī pētnieciskā darba autors nolēma uzsvērt humora izmantošanu starpkultūru uzņēmējdarbības saziņas kontekstā, veicot joku analīzi no lingvistikas un socioloģijas skatpunktiem General Theory of Verbal Humor un Superiority/Disparagement teoriju ietvaros. Par pētniecības metodēm tika izmantoti gadījuma analīze, kā arī starpkultūru uzņēmējdarbības diskursa analīze. Par šī darba korpusu tika izvēlēti 12 joki no starpkultūru uzņēmējdarbības konteksta. Noslēgumā tika pierādīts, ka visi joki ietvēra …
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19
2021
To understand how a protective immune response against SARS-CoV-2 develops over time, we integrated phenotypic, transcriptional and repertoire analyses on PBMCs from mild and severe COVID-19 patients during and after infection, and compared them to healthy donors (HD). A type I IFN-response signature marked all the immune populations from severe patients during the infection. Humoral immunity was dominated by IgG production primarily against the RBD and N proteins, with neutralizing antibody titers increasing post infection and with disease severity. Memory B cells, including an atypical FCRL5+ T-BET+ memory subset, increased during the infection, especially in patients with mild disease. A…
Ocular gelling microspheres: in vitro precorneal retention time and drug permeation through reconstituted corneal epithelium.
2008
Purpose: The model drug norfloxacin (NOR)was encapsulated into trehalose (TRH) and hydroxyethylcellulose(NAT) microspheres to obtain a novel gelling ophthalmic delivery system for prolonged release on corneal tissue. Methods: We assessed NOR release from microspheres, prepared by the emulsion-solvent evaporation method. A new in vitro tear turnover model, including inserts containing reconstituted human corneal epithelium (RHC), was designed to evaluate the TRH/NAT microspheres’ precorneal retention time. Bioadhesive properties of TRH/NAT microspheres were validated by using drug-loaded microspheres prepared with gelatine (GLT) commonly used as reference material in adhesion studies. Result…
The Inflammatory Feed-Forward Loop Triggered by the Complement Component C3 as a Potential Target in Endometriosis
2021
Copyright © 2021 Agostinis, Zorzet, Balduit, Zito, Mangogna, Macor, Romano, Toffoli, Belmonte, Morello, Martorana, Borelli, Ricci, Kishore and Bulla. The complement system is a major component of humoral innate immunity, acting as a first line of defense against microbes via opsonization and lysis of pathogens. However, novel roles of the complement system in inflammatory and immunological processes, including in cancer, are emerging. Endometriosis (EM), a benign disease characterized by ectopic endometrial implants, shows certain unique features of cancer, such as the capacity to invade surrounding tissues, and in severe cases, metastatic properties. A defective immune surveillance against…
Antibody injection in the egg yolk: maternal antibodies affect humoral immune response of the offspring
2010
Summary 1. In vertebrate species, maternal antibodies specific for the pathogens to which mothers have been exposed can be transmitted to offspring before birth. This is assumed to be adaptive as these antibodies can be essential in protecting offspring early in life before their own immune system is fully developed. However, fitness consequences in natural conditions and the long-term effects of these mechanisms have yet to be fully examined. 2. Exploring the ecological and evolutionary implications of such maternal effects requires experimental manipulations to avoid potential confounding maternal effects. In birds, maternal antibodies are transmitted via the egg yolk – a self contained e…
Physicochemical Surface Properties of Various Intraocular Lenses
2001
<i>Purpose:</i> It is of major interest to understand how intraocular lens (IOL) surfaces interact with aqueous humor or tissues after implantation. Important parameters to describe the physicochemical surface properties are the contact angle and critical surface tension. Therefore, we performed measurements of the contact angle and critical surface tension of several commercially available IOLs. <i>Setting:</i> Department of Ophthalmology, Johannes Gutenberg University, Mainz, University Eye Hospital, Tübingen, and Max Planck Institute for Polymer Research, Mainz, Germany. <i>Methods:</i> A total of 17 commercially available standard quality IOL types (6…
Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patt…
2007
To show the existence of IgG antibodies against retinal antigens in aqueous humor of normal tension glaucoma patients.Forty-two patients were included in this study. Aqueous humor was collected from control subjects (CO; n = 21) and patients with normal tension glaucoma (NTG; n = 21). Western blot methods against bovine retinal antigens were used to detect the IgG antibody patterns. The complex antibody repertoires were analyzed by multivariate statistical techniques. Mass spectrometry was used to identify the most important antigens.Very complex IgG antibody patterns against retinal antigens were found in all analyzed aqueous humor samples. Our multivariate approach could quantify differen…
Penetration of 2% cyclosporin eyedrops into human aqueous humour.
1989
The penetration into the eye and the systemic absorption of 2% cyclosporin eye drops were determined by polarisation immunofluorescent assay of cyclosporin in the aqueous humour and plasma of 30 patients at the time of cataract surgery. The results were then compared with the corresponding results after oral administration at a dosage of 5 mg/kg/day to three further patients. The maximum intraocular concentration (24 (SD 9) mg/l) was achieved four hours after topical administration. This level was slightly less than that found in aqueous humour (28 (SD 10) mg/l) 12 hours after systemic administration of the drug at a dosage of 5 mg/kg/day. Both these levels are below the minimum therapeutic…
La construcción de la imagen de la mujer en el humor gráfico del semanario de humor Hermano Lobo (1972 - 1976)
2014
La construcción de la imagen de la mujer en el humor gráfico del semanario de humor Hermano Lobo (1972 - 1976)