Search results for "Hydrochloride"

Levofloxacin effect on erlotinib absorption. Evaluation of the interaction in undernutrition situations through population pharmacokinetic analysis i…

2017

The main objective of this study was to develop a pharmacokinetic model in order to describe the intestinal absorption of erlotinib in rat and to quantify the interaction of levofloxacin on this process in well- and under-nourished rats. Absorption studies were performed in male Wistar rats. Concentration-time profiles in proximal and distal intestine were analysed through non-linear mixed effect modelling using the NONMEM software version 7.3. Simulations were performed in order to explore the influence of covariates on the apparent absorption rate constant. A passive absorption and an active secretion process best-described erlotinib absorption from lumen to enterocyte. The developed mode…

Polymere acroleine. III. Mittteilung. Oximierung und quantitative Bestimmung der Aldehydgruppen

1956

Die Oximierung von Disacryl wird beschrieben. Ferner werden Bedingungen fur eine quantitative Bestimmung von Aldehydgruppen in polymeren Acroleinen mitgeteilt. Es wird festgestellt, das Disacryl und ein durch Redox-Polymerisation gewonnenes Polyacrolein etwa 65% reaktionsfahige Aldehydgruppen enthalten. Bei Polyacroleinen, die mittels Borfluorid-Atherat oder Kaliumcarbonat gewonnen wurden, betragt der Umsatz mit Hydroxylamin nur etwa 20% d. Th. The oximation reaction of disacryl is described. The conditions of a quantitative determination of aldehyde function in polymeric acroleins have been investigated. It has been shown, that disacryl and an other polyacrolein, prepared by a redox-polyme…

In vitro antimicrobial activity of sodium hypochlorite, chlorhexidine gluconate and octenidine dihydrochloride in elimination of microor- ganisms wit…

2011

The aim of this study was to evaluate the effectiveness of different irrigation solutions at different time intervals for the elimination of E.faecalis and C.albicans penetrated into the dentine tubules of primary and permanent teeth in vitro. The 4 mm primary and permanent teeth sections were sterilized and contaminated with a mixture of E.faecalis and C.albicans strains. After the application of different irrigation solutions (Sodium hypochlorite, Chlorhexidine gluconate, Octenidine Dihydrochloride, saline) to the contaminated tooth sections according to study groups, neutralizers were applied for inactivation of the solutions after 30 sec, 1 min and 5 min. Dentine shavings were placed in…

Structure determination of three polymorphs of xylazine from laboratory powder diffraction data

2014

The crystal structures of three xylazine hydrochloride [N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiaz-2-amine hydrochloride] polymorphsA,ZandXhave been solved from powder diffraction data and refined using Rietveld refinement. Data were obtained with Cu Kα radiation. All polymorphs were found to have structures withZ′ = 1 andZ= 4. All the structures determined contained strong hydrogen bonds between the amino groups and chloride anions. The crystal structures of formsAandXfeatured π–π stacking interactions.

Raloxifene increases proliferation of human endothelial cells in association with increased gene expression of cyclins A and B1.

2006

Objective To examine the proliferative effect of of raloxifene on human umbilical-vein endothelial cells (HUVECs), and to investigate whether there is an associated increased expression of some key regulators of the cell cycle. Design Cell culture for different incubation times. Setting University research laboratory. Patient(s) Sources of HUVECs. Intervention(s) Measurement of cell proliferation, of protein levels of cyclin A, cyclin B1, cyclin D1, cyclin-dependent protein kinase (CDK) 2, CDK4, and p27 Kip1 , and of messenger RNA expression of cyclin A, cyclin B1, and p27 Kip1 . Main Outcome Measure(s) Cell proliferation was measured by the 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazol…

Therapeutic dosages of raloxifene do not modify myeloperoxidase and F2alpha-isoprostane levels in postmenopausal women.

2005

We investigated the effect of a therapeutic dose of raloxifene on the plasma levels of myeloperoxidase and F2alpha-isoprostanes, two markers of oxidative stress recently described as reliable indicators of coronary heart disease. Contrary to changes described in the literature for estrogens (E), raloxifene did not modify the levels of either myeloproxidase or F2alpha-isoprostanes after 3 or 6 months of treatment.

Are the serum levels of sCD40L modified by raloxifene in postmenopausal women?

2008

Raloxifene increases the capacity of serum to promote prostacyclin release in human endothelial cells: implication of COX-1 and COX-2.

2004

OBJECTIVE Prostacyclin is a potent vasodilator synthesized by two isoforms of cyclooxygenase in endothelium. The aim of this study was to investigate the effect of serum from postmenopausal women treated with raloxifene on prostacyclin production by human umbilical vein endothelial cells and on cyclooxygenases-1 and -2. DESIGN Serum was collected from 21 women receiving 60 mg/day of raloxifene, at baseline and at 3 and 6 months. Human umbilical vein endothelial cells were exposed to serum for 24 hours, and prostacyclin production was evaluated in supernatants. Selective inhibitors of cyclooxygenases-1 and -2 (SC-560 and NS-398) were used to investigate the relative contribution of each enzy…

CCDC 769714: Experimental Crystal Structure Determination

2011

Related Article: M.Palko, G.Benedek, E.Forro, E.Weber, M.Hanninen, R.Sillanpaa, F.Fulop|2010|Tetrahedron:Asymm.|21|957|doi:10.1016/j.tetasy.2010.05.003

CCDC 243018: Experimental Crystal Structure Determination

2006

Related Article: A.Guirado, R.Andreu, B.Martiz, D.Bautista, C.R.de Arellano, P.G.Jones|2006|Tetrahedron|62|6172|doi:10.1016/j.tet.2006.04.058