Search results for "I1"
showing 10 items of 74 documents
Dans quelle mesure les préférences individuelles contraignent-elles le développement du marché de l'assurance dépendance ?
2015
Dans un contexte de vieillissement de la population, différents scenarii sont envisagés pour réformer l’organisation et le financement de la prise en charge des personnes âgées dépendantes. La place de la prévoyance individuelle dans le financement de la dépendance est à ce titre largement débattue. À l’heure actuelle, malgré des restes à charge potentiellement conséquents, peu d’individus disposent d’une couverture assurantielle. Cet article vise à enrichir la littérature existante en évaluant dans quelle mesure les préférences observées dans la population limitent cette couverture. Nous mobilisons pour cela l’enquête Patrimoine et préférences vis-à-vis du temps et du risque (Pater) de 201…
The Saccharomyces cerevisiae flavodoxin-like proteins Ycp4 and Rfs1 play a role in stress response and in the regulation of genes related to metaboli…
2011
SPI1 is a gene whose expression responds to many environmental stimuli, including entry into stationary phase. We have performed a screening to identify genes that activate SPI1 promoter when overexpressed. The phosphatidylinositol- 4-phosphate 5-kinase gene MSS4 was identified as a positive activator of SPI1. Another SPI1 transcriptional regulator isolated was the flavodoxin-like gene YCP4. YCP4 and its homolog RFS1 regulate the expression of many genes during the late stages of growth. The double deletion mutant in YCP4 and its homolog RFS1 has an impact on gene expression related to metabolism by increasing the expression of genes involved in hexose transport and glycolysis, and decreasi…
Stress response and expression patterns in wine fermentations of yeast genes induced at the diauxic shift
2000
During wine fermentation yeasts quickly reach a stationary phase, where cells are metabolically active by consuming sugars present in grape must. It is, consequently, of great interest at this stage to identify suitable gene promoters that may be used to induce the expression of genes with enological applications. With this aim, we have studied a group of genes showing an induction peak at the diauxic shift, and possessing stress response elements (STRE) at their promoters. We have determined their induction levels under individualized stress conditions, such as carbon source starvation or high salt concentrations. In all the cases studied, the activation and/or basal transcription are depe…
The study of calcium signaling in lipid gustatory cells in mice
2012
The lipid-binding glycoprotein CD36, expressed by circumvallate papillae (CVP) of the mouse tongue, has been shown to be implicated in oro-gustatory perception of dietary lipids. We demonstrate that linoleic acid (LA) by activating sPLA2, cPLA2 and iPLA2 via CD36, produced arachidonic acid (AA) and lyso-phosphatidylcholine (Lyso-PC) which triggered Ca2+ influx in CD36-positive taste bud cells (TBC), purified from mouse CVP. LA induced the production of Ca2+ influx factor (CIF). CIF, AA and Lyso-PC exerted different actions on the opening of store-operated Ca2+ (SOC) channels, constituted of Orai proteins and regulated by STIM1, a sensor of Ca2+ depletion in the endoplasmic reticulum. We use…
Induced mutations in the TI1 gene encoding a major double-headed protease inhibitor in Pisum sativum L. can reduce significantly the inhibition of ta…
2013
BAP GEAPSI; International audience; Trypsin / chymotrypsin inhibitors in the seeds of many legume crop species are regarded as antinutritional proteins often leading to a requirement for heat-treatment of seed products prior to their use in feed. A TILLING resource developed in Pisum sativum L. (pea) was exploited to identify mutants in the major seed-expressed trypsin / chymotrypsin inhibitor gene, TI1, where the inhibition of either or both of the target enzymes may be reduced. Three lines with missense mutations in TI1, predicted to affect activity through alteration of (a) a conserved cysteine residue, (b) the P1′ serine within the active site of the chymotrypsin inhibitory domain or (c…
Infected persons by the fact of a public organism : is a fair compensation by the community realistic ? A graph-theory pproach
1999
The paper focuses on indirectly infected persons (persons infected by a person, infected by a person, etc., itself infected by a public organism, for AIDS, hepatitis C, etc.). It is assumed that fairness implies the national community to indemnify them. Graph theory is used to explain what is indirect infection. The concept of chains of infection, and their length is central. Re-infections are considered also because even individuals that are initially infected by another cause could become later indirectly infected by the public agent. The number of persons to be indemnified is larger than for direct infection, so the cost of compensation is higher, unless if compensation per capita is low…
Pharmaciens et coordination des soins primaires en France : quels enjeux ?
2019
Multi-professional coordination is a strong axis of the reorganization of primary care in France. While this coordination concerns a priori all health professionals, some of them actually are still marginally involved. This article examines the challenges of integrating pharmacists into primary care in France. On the one hand, it is based on an analysis of experiments carried out in other health systems, and on their evaluations. On the other hand, it develops an initial reflection on the levers and obstacles that could explain in France, the poor integration of pharmacists but also on the challenges of a stronger presence of these professionals in the coordination of primary care.
Coupled fixed point results in cone metric spaces for -compatible mappings
2011
Abstract In this paper, we introduce the concepts of -compatible mappings, b-coupled coincidence point and b-common coupled fixed point for mappings F, G : X × X → X, where (X, d) is a cone metric space. We establish b-coupled coincidence and b-common coupled fixed point theorems in such spaces. The presented theorems generalize and extend several well-known comparable results in the literature, in particular the recent results of Abbas et al. [Appl. Math. Comput. 217, 195-202 (2010)]. Some examples are given to illustrate our obtained results. An application to the study of existence of solutions for a system of non-linear integral equations is also considered. 2010 Mathematics …
Patient flows through Valhalla : A survival analysis in the context of short-term care institutions
2019
Master's thesis Business Administration BE501 - University of Agder 2019 Individuals experiencing functional decline may often require some form of assistance in order to reassume their activities of daily living. A common form of rehabilitation is a stay at a short-term institution, yet readmissions to such care facilities often occur. Home-based reablement has surfaced in Norway during the past ten years and aims to assist the user in reaching their own activity goals through a self-committed and intensive program, assisted by health care workers. The objective of this study isinquiring into the patient flows between home-nurse areas and short-term institutions in southern Norway over the…
THE EFFECTS OF PEOPLES’ HEIGHT AND RELATIVE HEIGHT ON WELL-BEING
2011
Using a rich Italian survey, we investigate the effect of height on individual happiness. From our analysis it emerges that a large part of the effect of height on well-being is driven by a positive correlation between height and economic and health conditions. However, for young males the effect of height on happiness persists even after controlling for these variables, implying that height may produce some psycho-social direct effects on well-being. Consistent with this hypothesis, we find that males care not only about their own height but also about the height of people in their reference group. Well-being is greater for individuals who are taller than other subjects in their reference …