Search results for "IBA"

Refined analysis of genetic variability parameters in hepatitis C virus and the ability to predict antiviral treatment response.

2008

Summary.  Hepatitis C virus (HCV) infects approximately 3% of the world population. The chronicity of hepatitis C seems to depend on the level of genetic variability. We have recently (Torres-Puente et al., J Viral Hepat, 2008; 15: 188) reported genetic variability estimates from a large-scale sequence analysis of 67 patients infected with HCV subtypes 1a (23 patients) and 1b (44 patients) and related them to response, or lack of, to alpha-interferon plus ribavirin treatment.. Two HCV genome regions were analysed in samples prior to antiviral therapy, one compressing the three hypervariable regions of the E2 glycoprotein and another one including the interferon sensitive determining region …

Genetic variability in hepatitis C virus and its role in antiviral treatment response

2007

Summary.  Hepatitis C virus (HCV) is a major health problem worldwide, infecting an estimated 170 million people. The high genetic variability of HCV contributes to the chronicity of hepatitis C. Here, we report results from a large-scale sequence analysis of 67 patients infected with HCV genotype 1, 23 with subtype 1a and 44 with subtype 1b. Two regions of the HCV genome were analysed in samples prior to combined therapy with alpha interferon plus ribavirin, one compressing the hypervariable regions (HVR1, HVR2 and HVR3) of the E2 glycoprotein and another one including the interferon-sensitive determining region (ISDR) and the V3 domain of the NS5A protein. Genetic diversity measures showe…

All-trans retinoic acid for treatment of chronic hepatitis C

2008

Background/Aims: In vitro studies in the subgenomic hepatitis C virus (HCV) replicon system have identified all-trans retinoic acid (ATRA) as a potential therapeutic against hepatitis C. Thus, the antiviral potential of this drug should be assessed in vivo. Methods: Twenty highly treatment experienced serotype 1 patients with non-response to conventional or pegylated interferon-α (Peg-/IFN-α) and ribavirin were randomly assigned to 12 weeks of monotherapy with ATRA (group A) or a combination of ATRA and PegIFN-α2a (group B). HCV RNA was assessed by bDNA assay and if negative by highly sensitive polymerase chain reaction. Results: During treatment, five of 10 patients in group A had a drop o…

PEG IFN alfa-2a vs. alfa-2b: And the winner is …?

2009

Abstract Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. McHutchison JG, Lawitz EJ, Shiffman ML, Muir AJ, Galler GW, McCone J, Nyberg LM, Lee WM, Ghalib RH, Schiff ER, Galati JS, Bacon BR, Davis MN, Mukhopadhyay P, Koury K, Noviello S, Pedicone LD, Brass CA, Albrecht JK, Sulkowski MS; IDEAL Study Team. N Engl J Med 2009 Aug 6;361(6):580–93. Background Treatment guidelines recommend the use of peginterferon alfa-2b or peginterferon alfa-2a in combination with ribavirin for chronic hepatitis C virus (HCV) infection. However, these regimens have not been adequately compared. Methods At 118 sites, patients who had HCV genotype 1 infection and who had not …

Antimitochondrial antibody -M2 positive autoimmune hepatitis during standard of care for chronic hepatitis C

2012

The current standard of care (SoC) for chronic hepatitis C, i.e. the combination of a pegylated-interferon (PEG-IFN) with ribavirin (RBV), may activate underlying autoimmune conditions. Particularly, interferon (IFN) has been known to induce or exacerbate autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) in hepatitis C virus patients. We describe a severe, acute-onset antimitochondrial antibody (AMA)-M2 positive AIH appearing during the last weeks of SoC in a woman with chronic hepatitis C and no previous history of autoimmunity, and resolving on protracted steroids. In this context, the relevance of the characterization of the immunoglobulin isotype of portal plasma cells for …

La llengua de Carles Riba: el cas de Guillot, bandoler

2015

Resum: En l'àmbit d'un estudi sistemàtic sobre la llengua de Carles Riba, n'analitzem aquí un conte primerenc. Guillot, bandoler, publicat probablement cap al 1918, representa la primera incursió de l'autor en la narrativa per a infants, en un moment en què la fixació de l'ortografia i la normativa fabrianes encara es troba en evolució.  Hi veiem, doncs, un llenguatge que aspira a la correcció però que és al mateix temps espontani, mentre podem relacionar-ne alguns trets característics amb la voluntat d'adherir-se a un gènere narratiu concret. En aquest sentit, la tradició rondallística admet la presència de termes de registre més elevat en un context de mímesi literària del llenguatge parl…

Inbreeding does not alter the response to an experimental heat wave in a freshwater snail

2019

Global climate change affects natural populations of many species by increasing the average temperature and the frequency of extreme weather events (e.g. summer heat waves). The ability of organisms to cope with these environmental changes can, however, depend on their genetic properties. For instance, genetic load owing to inbreeding could alter organisms’ responses to climate change-mediated environmental changes but such effects are often overlooked. We investigated the effects of an experimental heat wave (25°C versus 15°C) on life history (reproduction, size) and constitutive immune defence traits (phenoloxidase-like and antibacterial activity of haemolymph) in relation to inbreeding b…

NEW HYALURONAN-BASED HYDROGEL AS RESOBABLE ANTIBACTERIAL COATING FOR PREVENTION OF IMPLANT-RELATED INFECTION IN ORTHOPAEDICS

2014

Rakstveida pierādījumi starptautisko komerciālo šķīrējtiesu procesā

2016

Starptautiskās komerciālās šķīrējtiesas procesā nav vienoti procesuāli noteikumi, kas regulētu ar pierādījumiem saistītus jautājumus, līdz ar to pastāvošā prakse attiecībā uz pierādījumu iegūšanu ir daudzveidīga. To īpaši ietekmē apstāklis, ka dažādos tiesību lokos izpratne par pierādījumiem atšķiras. Tas savukārt noved pie tā, ka attiecībā uz vienu no efektīvākajiem pierādījumu iegūšana veidiem – rakstveida pierādījumu izprasīšanu, starptautisko komerciālo šķīrējtiesu procesos valda nevienprātība un tā tiek dažādi realizēta. Bez tam neskaidrību šī pierādījuma iegūšanas veida realizācija rada augušā elektronisko dokumentu nozīme mūsdienu biznesa vidē. Pētījuma mērķis ir, analizējot šķīrējti…

Enhanced Efficacy and Broadening of Antibacterial Action of Drugs via the Use of Capped Mesoporous Nanoparticles

2013

[EN] A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with epsilon-poly-L-lysine (epsilon-PL) was prepared and its interaction with different Gram-negative bacteria studied. A remarkable improvement in the efficacy of the antimicrobial drug epsilon-PL and a broadening of the antimicrobial spectrum of vancomycin is demonstrated.