Search results for "IBA"

showing 10 items of 1355 documents

Managing hepatitis C in liver transplant patients with recurrent infection

2009

Tim Zimmermann1, Gerd Otto2, Marcus Schuchmann11Department of Internal Medicine, 2Transplantation Surgery, University of Mainz, GermanyAbstract: Hepatitis C virus (HCV) reinfection after liver transplantation (LT) and recurrent hepatitis C often lead to recurrent cirrhosis (RC). RC is one of the most frequent complications resulting in organ failure and early death after LT in HCV-positive patients with reported 5-year rates from 20% to 40%. As HCV-cirrhosis is one of the leading indications for LT, the therapeutic management is a central issue. To date, the best available therapy is a combination of pegylated interferon + ribavirin in patients with established recurrent hepatitis C proven …

Medicine (General)medicine.medical_specialtyCirrhosisHepatitis C virusmedicine.medical_treatmentLiver transplantationmedicine.disease_causeGastroenterologychemistry.chemical_compoundR5-920Pegylated interferonInternal medicinemedicineTransplantationmedicine.diagnostic_testbusiness.industryRibavirinHepatitis Cmedicine.diseaseSurgerychemistryTolerabilityLiver biopsyStatistics Probability and Uncertaintybusinessmedicine.drugTransplant Research and Risk Management
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Medicinal Properties of Mediterranean Oyster Mushrooms: Species of Genus Pleurotus (Higher Basidiomycetes)

2017

The term “Mediterranean area,” applied in this chapter, refers to the definition reported in Med-Checklist and particularly to all countries bordering the Mediterranean Sea plus Portugal, Bulgaria, the Crimea (Ukraine), and Jordan. The “Mediterranean oyster mushrooms” is a geographically and ecologically well-defined group of Basidiomycetes. The medicinal properties of some widely investigated species such as Pleurotus ostreatus and P. eryngii are recognized worldwide, while in the case of some other Mediterranean Pleurotus taxa, there is still a lack of knowledge. A substantial increase in knowledge about the anticancer and antibacterial properties of the group of Pleurotus species growing…

Mediterranean climatePleurotusOysterbiologySettore BIO/02 - Botanica SistematicaFamily Apiaceaebiology.organism_classificationMediterranean area Medicinal mushrooms Antibacterial activity Oyster mushrooms PleurotusTaxonMediterranean seaGenusbiology.animalBotanySettore BIO/03 - Botanica Ambientale E ApplicataPleurotus ostreatus
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Antibacterial activity and HPLC analysis of extracts from Mediterranean brown algae

2020

The antibacterial activity of methanolic extracts of eight Mediterranean brown algae belonging to the genera Cystoseira sensu lato, Dictyopteris and Padina was investigated. Extracts from Sargassaceae showed antibacterial activity. Specifically, Carpodesmia crinita and Carpodesmia brachycarpa extracts inhibited the growth of the Gram-positive strain Kocuria rhizophila whereas Cystoseira compressa and Carpodesmia amentacea extracts showed antibacterial activity against the Gram-positive strains, Kocuria rhizophila and Staphylococcus aureus. None of them inhibited the growth of the Gram-negative bacterium Escherichia coli. The extracts of Cystoseira sp. pl. and Treptacantha ballesterosii did …

Mediterranean climatemethanolic extractPlant ScienceBiologyCystoseirabrown algaeSettore BIO/19 - Microbiologia Generale01 natural sciences03 medical and health sciencesSensuBotanyMediterranean SeaSettore BIO/04 - Fisiologia VegetaleEcology Evolution Behavior and Systematics030304 developmental biology0303 health sciencesHplc analysis010405 organic chemistrySettore BIO/02 - Botanica SistematicaSettore CHIM/06 - Chimica Organicabiology.organism_classificationphenol compoundpolar metabolites0104 chemical sciencesBrown algaeAntibacterial activityAntibacterial activityPlant Biosystems - An International Journal Dealing with all Aspects of Plant Biology
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L'abolizione delle Province in Sicilia: resoconto semiserio di un rivoluzione in progress

2014

Mentre a livello nazionale era in corso il dibattito sul destino delle Province la Regione Sicilia ha inteso anticipare i tempi procedendo all'abolizione delle proprie Province e la loro sostituzione da parte dei Liberi Consorzi comunali e delle Città metropolitane. Tuttavia l'esatto dimensionamento funzionale dei due nuovi enti resta affidato alla futura legislazione così come incerte appaiono le modalità per la riorganizzazione dei servizi del personale e delle risorse. Il dubbio che tutto rimanga come prima e che la rivoluzione si concreti nella pratica nel mantenimento dell'esistente seppur rivisto sul piano della rappresentatività politica appare molto più che fondato.
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A Sensitive Nanosensor for the In Situ Detection of the Cannibal Drug.

2020

[EN] A bio-inspired nanodevice for the selective and sensitive fluorogenic detection of 3,4- methylenedioxypyrovalerone (MDPV), usually known as Cannibal drug, is reported. The sensing nanodevice is based on mesoporous silica nanoparticles (MSNs), loaded with a fluorescent reporter (rhodamine B) and functionalized on their external surface with a dopamine derivative (3), which specifically interacts with the recombinant human dopamine transporter (DAT), capping the pores. In the presence of MDPV, DAT detaches from the MSNs consequently causing rhodamine B release and allowing drug detection. The nanosensor shows a detection limit of 5.2 µM and it is able to detect the MDPV drug both in sali…

Mesoporous silica nanoparticlesDopamineNanosensorNanoparticleBioengineeringDrug detectionMDPVchemistry.chemical_compoundQUIMICA ORGANICANanosensorQUIMICA ANALITICARhodamine Brecombinant human dopamine transporterHumansmesoporous silica nanoparticlesInstrumentationNanodeviceDopamine transporterFluid Flow and Transfer ProcessesDetection limitbiologyProcess Chemistry and TechnologyQUIMICA INORGANICAMesoporous silicaSilicon DioxidechemistryPharmaceutical Preparationsbiology.proteinBiophysicsNanoparticlesRecombinant human dopamine transporter (DAT)nanosensorcannibal drugCannibal drugACS sensors
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Exploiting redox activity of MIL-100(Fe) carrier enables carvacrol prolonged antimicrobial activity

2021

The design of efficient food contact materials that maintain optimal levels of food safety is of paramount relevance to reduce the increasing foodborne illnesses. In this work, we develop a smart composite MOF-based material that fosters a unique prolonged antibacterial activity. The composite is obtained by entrapping a natural preserving food molecule, carvacrol, into the mesoporous MIL-100(Fe) material following a direct and biocompatible impregnation method and obtaining particularly high payloads. By exploiting the intrinsic redox nature of MIL-100(Fe) material it is possible to achieve a prolonged activity against E. coli bacteria due to a triggered two-step carvacrol release of films…

Metalchemistry.chemical_compoundFood contact materialschemistryvisual_artComposite numbervisual_art.visual_art_mediumMoleculeCarvacrolAntibacterial activityMesoporous materialCombinatorial chemistryRedox
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Synthesis and antibacterial activity of iron-hexacyanocobaltate nanoparticles.

2018

This paper deals with the synthesis and characterization of iron-hexacyanocobaltate (FeHCC) and its antibacterial properties. The nanoparticles were prepared by a facile co-precipitation technique. Crystal structure, particle morphology, and elemental composition were determined using X-ray Powder Diffraction, X-ray fluorescence spectroscopy, Transmission Electron Microscopy (TEM), and Infrared Spectroscopy (IR). The antibacterial activity of the FeHCC nanoparticles was tested against Escherichia coli and Staphylococcus aureus as models for Gram-negative and Gram-positive bacteria, respectively, by bacterial counting method and microscopic visualization (TEM, FEG-SEM, and fluorescence micro…

Metal-hexacyanoferrateStaphylococcus aureusIronColony Count MicrobialInfrared spectroscopyNanoparticleMetal Nanoparticles02 engineering and technologyMicrobial Sensitivity TestsBacterial growth010402 general chemistrymedicine.disease_cause01 natural sciencesBiochemistryFluorescence spectroscopyInorganic ChemistryMicroscopy Electron TransmissionmedicineFluorescence microscopeEscherichia coliEscherichia coliCyanidesChemistryIron-hexacyanocobaltateCobalt021001 nanoscience & nanotechnology0104 chemical sciencesAnti-Bacterial AgentsSpectrometry FluorescenceStaphylococcus aureuMicroscopy Electron ScanningAntibacterial activity0210 nano-technologyAntibacterial activityReactive Oxygen SpeciesNuclear chemistryMacromoleculeJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
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New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens

2013

The synthesis and the in vitro antibacterial activity of novel linezolid-like oxadiazoles are reported. Replacement of the linezolid morpholine C-ring with 1,2,4-oxadiazole results in an antibacterial activity against Staphylococcus aureus both methicillin-susceptible and methicillin-resistant comparable or even superior to that of linezolid. While acetamidomethyl or thioacetoamidomethyl moieties in the C(5) side-chain are required, fluorination of the phenyl B ring exhibits a slight effect on an antibacterial activity but its presence seems to reduce the compounds cytotoxicity. Molecular modeling performed using two different approaches - FLAP and Amber software - shows that in the binding…

Methicillin-Resistant Staphylococcus aureusModels MolecularCell viabilityStaphylococcus aureusMolecular modelCell SurvivalMicrobial Sensitivity TestsAntimicrobial activityCrystallography X-Raymedicine.disease_causeDrug designMicrobiologyStructure-Activity Relationshipchemistry.chemical_compoundoxadiazoles linezolid antibioticsCell Line TumorDrug Resistance Multiple BacterialMorpholineAcetamidesDrug DiscoverymedicineHumansMoietyStructure–activity relationshipOxazolidinonesPharmacologyOxadiazolesOxazolidinones; Linezolid; Drug designDose-Response Relationship DrugMolecular StructureChemistryOrganic ChemistryLinezolidSettore CHIM/06 - Chimica OrganicaHep G2 CellsGeneral Medicinebiochemical phenomena metabolism and nutritionbacterial infections and mycosesSettore CHIM/08 - Chimica FarmaceuticaMethicillin-resistant Staphylococcus aureusCombinatorial chemistryOxazolidinoneAnti-Bacterial AgentsStaphylococcus aureusMED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICALinezolidAntimicrobial activity; Cell viability; Drug design; Oxazolidinones; Staphylococcus aureusAntibacterial activitySoftware
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Aerobic and facultatively anaerobic cellulolytic bacteria from the gut of the termite Zootermopsis angusticollis.

2002

Aims: To demonstrate the occurrence of cellulolytic bacteria in the termite Zootermopsis angusticollis. Methods and Results: Applying aerobic cultivation conditions we isolated 119 cellulolytic strains from the gut of Z. angusticollis, which were assigned to 23 groups of aerobic, facultatively anaerobic or microaerophilic cellulolytic bacteria. 16S rDNA restriction fragment pattern and partial 16S rDNA sequence analysis, as well as numerical taxonomy, were used for the assignment of the isolates. The Gram-positive bacteria of the actinomycetes branch could be assigned to the order Actinomycetales including the genera Cellulomonas/Oerskovia, Microbacterium and Kocuria. The Gram-positive bact…

MicrobacteriumIsopteraGram-Positive BacteriaApplied Microbiology and BiotechnologyDNA RibosomalMicrobiologyPaenibacillusRNA Ribosomal 16SGram-Negative BacteriaAnimalsCellulomonasAnaerobiosisCellulosebiologyBrevibacillusGeneral MedicineSequence Analysis DNAbiology.organism_classificationBacillalesAerobiosisCulture MediaKocuriaIntestinesBiodegradation EnvironmentalZootermopsis angusticollisBacteriaBiotechnologyJournal of applied microbiology
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Rapid isolation of single microbial cells from mixed natural and laboratory populations with the aid of a micromanipulator.

1999

In order to facilitate the isolation of pure cultures from natural habitats we have developed a method for the isolation of single microbial cell clones from a mixed population, e.g. the flora of the termite gut, with the aid of a modern micromanipulator. The separated single prokaryotic or eukaryotic cells were grown after transfer in culture media or they were used for single cell PCR. The micromanipulator was also applied for the removal of nuclei from protozoa, of which the SSU rDNA was directly amplified.

Microbiological TechniquesPopulationmedicine.disease_causeApplied Microbiology and BiotechnologyMicrobiologylaw.inventionMicrobiologyMicromanipulationlawmedicineAnimalseducationMicromanipulatorEcology Evolution Behavior and SystematicsPhylogenyeducation.field_of_studybiologyBacteriaEukaryotaMycoplasmabiology.organism_classificationIsolation (microbiology)ArchaeaMethanobrevibacterProtozoaBacteriaArchaeaSystematic and applied microbiology
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