6533b831fe1ef96bd1299045

RESEARCH PRODUCT

A Sensitive Nanosensor for the In Situ Detection of the Cannibal Drug.

Borja Díaz De GreñuAna M. CosteroAna M. CosteroMaría AlfonsoSalvador GilSalvador GilFélix SancenónMaría Dolores MarcosRamón Martínez-máñezEva Garrido

subject

Mesoporous silica nanoparticlesDopamineNanosensorNanoparticleBioengineeringDrug detectionMDPVchemistry.chemical_compoundQUIMICA ORGANICANanosensorQUIMICA ANALITICARhodamine Brecombinant human dopamine transporterHumansmesoporous silica nanoparticlesInstrumentationNanodeviceDopamine transporterFluid Flow and Transfer ProcessesDetection limitbiologyProcess Chemistry and TechnologyQUIMICA INORGANICAMesoporous silicaSilicon DioxidechemistryPharmaceutical Preparationsbiology.proteinBiophysicsNanoparticlesRecombinant human dopamine transporter (DAT)nanosensorcannibal drugCannibal drug

description

[EN] A bio-inspired nanodevice for the selective and sensitive fluorogenic detection of 3,4- methylenedioxypyrovalerone (MDPV), usually known as Cannibal drug, is reported. The sensing nanodevice is based on mesoporous silica nanoparticles (MSNs), loaded with a fluorescent reporter (rhodamine B) and functionalized on their external surface with a dopamine derivative (3), which specifically interacts with the recombinant human dopamine transporter (DAT), capping the pores. In the presence of MDPV, DAT detaches from the MSNs consequently causing rhodamine B release and allowing drug detection. The nanosensor shows a detection limit of 5.2 µM and it is able to detect the MDPV drug both in saliva and blood plasma samples.

yearjournalcountryeditionlanguage
2020-01-01ACS sensors
10.1021/acssensors.0c01553https://pubmed.ncbi.nlm.nih.gov/32844649