Search results for "ICAD"
showing 10 items of 1297 documents
EmPeCemos: un programa multicomponente para la prevención indicada de los problemas de conducta y el abuso de drogas
2009
En la última década, un amplio número de investigaciones ha permitido constatar la existencia de trayectorias de desarrollo desadaptativas, asociadas a problemas de conducta de inicio temprano. Estas trayectorias, en las que se implica una compleja cadena de factores familiares, escolares y socioemocionales, dan lugar a desajustes comportamentales crónicos y severos, de difícil tratamiento, incluyendo comportamientos antisociales y abuso de drogas. Por ello, la investigación en prevención subraya la necesidad de una intervención temprana que, actuando sobre los individuos en alto riesgo y su entorno, permita detener el avance hacia patrones severos de desadaptación. En esta línea, se desarr…
Synthesis of Densely Functionalised 5-Halogen-1,3-oxazin-2-ones byHalogen-Mediated Regioselective Cyclisation of N-Cbz-ProtectedPropargylic Amines: A…
2013
A very efficient synthesis of 5-halogen-1,3-oxazin-2-ones has been accomplished by the halocyclisation reaction of chiral nonracemic N-carbobenzyloxy (N-Cbz)-protected propargylic amines by using I-2, Br-2 and Cl-2 as electrophile sources. The nature of the halogen influences the reaction time and yield. However, in all cases the reaction is totally regioselective taking place through a 6-endo-dig process regardless of the nature of the halogen and of the substituents in the starting material. To rationalise the experimental results, theoretical studies at the B3LYP/6-311G* level have been performed.
Enantioselective alkynylation of benzo[e][1,2,3]-oxathiazine 2,2-dioxides catalysed by (R)-VAPOL-Zn complexes: synthesis of chiral propargylic cyclic…
2015
[EN] (R)-VAPOL-Zn(II) complexes catalysed the enantioselective addition of terminal alkynes to cyclic benzoxathiazine 2,2-dioxides, providing the corresponding chiral propargylic sulfamidates with high yields (up to 93%) and good enantiomeric excesses (up to 87%).
El enfoque de las capacidades de Amartya Sen: alcance y límites.
2007
La tesis tiene como objetivo analizar el sentido, alcance, límites e implicaciones del enfoque de las capacidades elaborado por Amartya Sen desde el ámbito de la filosofía moral y política. Al indagar por el sentido se busca saber qué es el enfoque de las capacidades y cuáles sus aspectos constitutivos. Al explorar el alcance se examina el aporte que brinda el enfoque frente a otros conceptos centrales de diferentes propuestas normativas para una sociedad libre e igualitaria como renta básica, derechos, necesidades básicas, capital humano, calidad de vida y desarrollo humano. Los límites de la propuesta se elaboran a lo largo del trabajo en diálogo con sus críticos (Rawls, Dworkin, Pogge, C…
Morphological alterations in the hippocampus of the Ts65Dn mouse model for Down syndrome correlate with structural plasticity markers
2018
Down syndrome (DS) is the most common chromosomal aneuploidy. Although trisomy on chromosome 21 can display variable phenotypes, there is a common feature among all DS individuals: the presence of intellectual disability. This condition is partially attributed to abnormalities found in the hippocampus of individuals with DS and in the murine model for DS, Ts65Dn. To check if all hippocampal areas were equally affected in 4-5 month adult Ts65Dn mice, we analysed the morphology of dentate gyrus granule cells and cornu ammonis pyramidal neurons using Sholl method on Golgi-Cox impregnated neurons. Structural plasticity has been analysed using immunohistochemistry for plasticity molecules follow…
Some classes of finite groups and mutually permutable products
2008
[EN] This paper is devoted to the study of mutually permutable products of finite groups. A factorised group G=AB is said to be a mutually permutable product of its factors A and B when each factor permutes with every subgroup of the other factor. We prove that mutually permutable products of Y-groups (groups satisfying a converse of Lagrange's theorem) and SC-groups (groups whose chief factors are simple) are SC-groups, by means of a local version. Next we show that the product of pairwise mutually permutable Y-groups is supersoluble. Finally, we give a local version of the result stating that when a mutually permutable product of two groups is a PST-group (that is, a group in which every …
The disease-specific clinical trial network for primary ciliary dyskinesia: PCD-CTN
2022
Primary ciliary dyskinesia; Rare genetic disorder; Lung diseases Discinesia ciliar primaria; Trastorno genético raro; Enfermedades pulmonares Discinesia ciliar primària; Trastorn genètic rar; Malalties pulmonars Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterised by impaired mucociliary clearance leading to irreversible lung damage. In contrast to other rare lung diseases like cystic fibrosis (CF), there are only few clinical trials and limited evidence-based treatments. Management is mainly based on expert opinions and treatment is challenging due to a wide range of clinical manifestations and disease severity. To improve clinical and translational research and facili…
On the exponent of mutually permutable products of two abelian groups
2016
In this paper we obtain some bounds for the exponent of a finite group, and its derived subgroup, which is a mutually permutable product of two abelian subgroups. They improve the ones known for products of finite abelian groups, and they are used to derive some interesting structural properties of such products.
The diamond partial order in rings
2013
In this paper we introduce a new partial order on a ring, namely the diamond partial order. This order is an extension of a partial order defined in a matrix setting in [J.K. Baksalary and J. Hauke, A further algebraic version of Cochran's theorem and matrix partial orderings, Linear Algebra and its Applications, 127, 157--169, 1990]. We characterize the diamond partial order on rings and study its relationships with other partial orders known in the literature. We also analyze successors, predecessors and maximal elements under the diamond order.
ON A QUESTION OF BEIDLEMAN AND ROBINSON
2002
[EN] In [J. C. Beidleman, D. J. S. Robinson, J. Algebra 1997, 191, 686--703, Theorem A], Beidleman and Robinson proved that if a group satisfies the permutizer condition, it is soluble, its chief factors have order a prime number or 4 and G induces the full group of automorphisms in the chief factors of order 4. In this paper, we show that the converse of this theorem is false by showing some counterexamples. We also find some sufficient conditions for a group satisfying the converse of that theorem to satisfy the permutizer condition.