Search results for "ICT."

Lichen sclerosus Mistaken for Sexual Abuse – Prevention of Victimization

2014

This case report describes the forensic examination of 7 girls aged between 4-11 years with suspected sexual abuse. The children had been reported by local pediatricians, hospital physicians or authorities such as the youth welfare office and police due to mucosal changes in the anogenital area. All children presented with a clearly delimited, porcelain-like white discoloration of the skin in the anal and genital area with atrophic conversion to parchment-like skin. The markedly vulnerable skin exhibited very different manifestations of hemorrhagic dermal and mucosal defects in the area of the labia, the clitoris, the perineum and the perianal region. The hymen was intact in all cases. The …

Welche Vorteile bringt eine umfassende Diagnostik mit OPD-KJ bei kinder- und jugendpsychiatrischen Patienten?

2013

Fragestellung: Dieser Beitrag stellt die Vorteile einer umfassenden OPD-KJ Diagnostik für eine kinder- und jugendpsychiatrische Stichprobe dar. Methodik: Drei Achsen der OPD-KJ, die Konflikt- und Strukturachse sowie die Achse Behandlungsvoraussetzungen wurden zusätzlich zum MAS und der ICD-10 Diagnose an einer Gruppe von 61 stationären kinder- und jugendpsychiatrischen Patienten in Österreich eingeschätzt. Ergebnisse: Es zeigten sich deutliche Geschlechtsunterschiede in der Bedeutung internalisierter, entwicklungshemmender Konflikte, allerdings war das Strukturniveau bei allen Patienten einheitlich im Bereich gering bis mäßig angesiedelt, d. h. Strukturleistungen wie Umgang mit negativen A…

Esperienze sfavorevoli infantili ed Intimate Partner Violence in età adulta

Coronavirus Diseases (COVID-19) Current Status and Future Perspectives: A Narrative Review

2020

At the end of 2019 a novel virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing severe acute respiratory syndrome expanded globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus a global pandemic. We performed a narrative review to describe existing literature with regard to Corona Virus Disease 2019 (COVID-19) epidemiology, pathophysiology, diagnosis, management and future perspective. MEDLINE, EMBASE and Scopus databases were searched for relevant articles. Although only when the pandemic ends it will be possible to assess the full health, social and economic impact of this global disaster, this review represents a pic…

A New Extraordinary Dream: A Study of Late-Qing Foreign Fiction Translations from the Perspective of Titology

2022

In the early stage of the introduction of foreign fiction to Chinese readers, newspapers and magazines played a pioneering role in the development of the discourse on the social role of fiction in modern Chinese society. This is particularly true for Shanghai newspaper Shenbao, which introduced a large number of Western novels, trying to fuel readers’ curiosity while avoiding any possible discomfort caused by foreignising or destabilising content. As a privileged type of paratext and the first element with whom readers came into contact, titles and their translations were key elements for promoting the new literary section and increasing daily sales. By adopting the theoretical framework of…

Biosystematic studies on the genus Polygonatum (Convallariaceae) IV. Molecular phylogenetic analysis based on restriction site mapping of the chlorop…

1997

Phylogenetic relationships of 14 species and one variety of the genus Polygonatum as well as three species of the genus Disporopsis and Heteropolygonatum roseolum were analyzed based on mapped restriction site variation in a PCR-amplified chloroplast genome region, trnK. In agreement with earlier taxonomic treatments it was found that Disporopsis and Heteropolygonatum should be distinguished from Polygonatum at generic level, and that P. sect. Polygonatum can be recognized as a monophyletic group. Earlier series concepts in P. sect. Polygonatum based on chromosome number and characteristics of staminal filaments are not supported by the molecular data. The molecular data suggest that satell…

Plasma non-cholesterol sterols: a useful diagnostic tool in pediatric hypercholesterolemia.

2010

Current guidelines strongly recommend the identification of genetic forms of hypercholesterolemia (HC) during childhood. The usefulness of non–cholesterol sterols (NCS) in the diagnosis of genetic HC has not been fully explored. Plasma NCS were measured by gas chromatography/mass spectrometry (GC/MS) in 113 children with hypercholesterolemia affected by: autosomal dominant hypercholesterolemia (ADH), familial combined hyperlipidemia (FCHL), polygenic hypercholesterolemia (PHC), and in 79 controls to evaluate: i) plasma NCS profile in different genetic HC and ii) the usefulness of NCS for the diagnosis of HC beyond current clinical criteria. ADH was characterized by raised lathosterol/total …

RIP-Chip analysis supports different roles for AGO2 and GW182 proteins in recruiting and processing microRNA targets.

2019

Background MicroRNAs (miRNAs) are small non-coding RNA molecules mediating the translational repression and degradation of target mRNAs in the cell. Mature miRNAs are used as a template by the RNA-induced silencing complex (RISC) to recognize the complementary mRNAs to be regulated. To discern further RISC functions, we analyzed the activities of two RISC proteins, AGO2 and GW182, in the MCF-7 human breast cancer cell line. Methods We performed three RIP-Chip experiments using either anti-AGO2 or anti-GW182 antibodies and compiled a data set made up of the miRNA and mRNA expression profiles of three samples for each experiment. Specifically, we analyzed the input sample, the immunoprecipita…

Development of predictive retention-activity relationship models of non-steroidal anti-inflammatory drugs by micellar liquid chromatography: comparis…

2000

The predictive and interpretative capability of quantitative chromatographic retention-biological activity models is supported by the fact that under adequate experimental conditions the solute partitioning into chromatographic system can emulate the solute partitioning into lipid bilayers of biological membranes, which is the basis for drug and metabolite uptake, passive transport across membranes and bioaccumulation. The use of micellar solutions of Brij35 as mobile phases in reversed-phase liquid chromatography has proven to be valid to predict some biological activities of different kinds of drugs. In this study, quantitative retention-activity relationship (QRAR) models to describe som…

Candesartan Cilexetil In Vitro-In Vivo Correlation: Predictive Dissolution as a Development Tool

2020

[EN] The main objective of this investigation was to develop an in vitro-in vivo correlation (IVIVC) for immediate release candesartan cilexetil formulations by designing an in vitro dissolution test to be used as development tool. The IVIVC could be used to reduce failures in future bioequivalence studies. Data from two bioequivalence studies were scaled and combined to obtain the dataset for the IVIVC. Two-step and one-step approaches were used to develop the IVIVC. Experimental solubility and permeability data confirmed candesartan cilexetil. Biopharmaceutic Classification System (BCS) class II candesartan average plasma profiles were deconvoluted by the Loo-Riegelman method to obtain th…