Search results for "ICT"
showing 10 items of 7961 documents
DEVELOPMENT & QUALIFICATION OF BIOASSAYS FOR THE DETERMINATION OF THE BIOACTIVITY, PREDICTIVE PHARMACOKINETICS AND POTENTIAL IMMUNOGENICITY OF THERAP…
2021
The critical quality attributes of a given biotherapeutic monoclonal antibody (mAb), its molecular characterization, functional assessment and effector function analysis should be defined and profiled in detail during the life cycle of a biotherapeutic drug. In the past, this product characterization was simple and standardized. In today’s complex world of biologics, success demands a more thoughtful approach and drug developers are investing in advanced analytics much earlier in the development process. Indeed, investing in selected sophisticated and state of the art analytics in early developmental phases of a therapeutic monoclonal antibody may mitigate risks by confirming that the drug …
Resolving reading disability : Childhood predictors and adult-age outcomes
2019
We examined frequency of adult‐age reading disability (RD) and its childhood predictors among 48 adults (20 to 39 years) with documented childhood RD, and contrasted their cognitive skills, education, and employment with 37 matched controls. Among individuals with childhood RD, more than half had improved in their reading fluency to the level where the set criterion for adult‐age RD was not met anymore. More fluent rapid naming, less severe childhood RD, and multiple support providers in childhood together predicted improvement of reading fluency. More fluent naming differentiated the childhood RD participants whose reading fluency had improved by adult‐age from those participants whose RD …
Clinical characteristics and predictors of death among hospitalized patients infected with SARS‑CoV‑2 in Sicily, Italy: A retrospective observational…
2022
Since late December 2019, severe acute respiratory syndrome coronavirus 2 has spread across the world, which resulted in the World Health Organization declaring a global pandemic. Coronavirus disease 2019 (COVID-19) presents a highly variable spectrum with regard to the severity of illness. Most infected individuals exhibit a mild to moderate illness (81%); however, 14% have a serious disease and 5% develop severe acute respiratory distress syndrome (ARDS), requiring intensive care support. The mortality rate of COVID-19 continues to rise across the world. Data regarding predictors of mortality in patients with COVID 19 are still scarce but are being actively investigated. The present multi…
Prefaces in medical dictionaries: from moves to rhetorical analysis
2017
Medical dictionaries represent, among the other things, an important pedagogic genre (Swales 1995, Bhatia, 1997, Hyland 2000) within academic education, since they are the means through which professional writers talk about their disciplines and address to scholars. The preface sections are of the utmost importance since, among several functions, they (should) attract and orient the readers (Azar, 2012). This paper describes the macro structure of preface sections in fourteen English dictionaries related to the field of medicine and investigates on the rhetorical and discursive devices employed in these texts to establish the importance of the author's work. In addition, the paper questions…
Interactively Learning the Preferences of a Decision Maker in Multi-objective Optimization Utilizing Belief-rules
2020
Many real life problems can be modelled as multiobjective optimization problems. Such problems often consist of multiple conflicting objectives to be optimized simultaneously. Multiple optimal solutions exist to these problems, and a single solution cannot be said to be the best without preferences given by a domain expert. Preferences can be used to find satisfying solutions: optimal solutions, which best match the expert’s preferences. To model the preferences of the expert, and aid him/her in finding satisfying solutions, a novel method is proposed. The method utilizes machine learning combined with belief-rule based systems to adaptively train a belief rule based system to learn a domai…
Efecto de la dosis de intervención del Programa de Apoyo Psicológico P/Materno Infantil© sobre las madres y sus bebés
2014
This paper presents an analysis of the intervention dose-effect of the Parent Child Psychological Support Program© (Cerezo 1990) a program aimed at promoting protective adaptive system in children which is offered to all new-borns in a given catchment area. The program offers support to parents during the first 18 months of the baby's life. The program dose-effect is examined regarding the parents by examining the level of distress reported by them and with babies by examining the development of attachment using the Strange Situation test of Ainsworth et al. (1978). The study is based on 342 families who made between 2 and 4 visits to the Program before being evaluation post-intervention. T…
Examining pre-service teachers' Technological Pedagogical Content Knowledge as evolving knowledge domains : A longitudinal approach
2019
The aim of this study is to outline the development and changes in pre‐service teachers' technological pedagogical content knowledge (TPACK) assessments during the first 3 years in teacher education. Specifically, research was conducted at three measurement points over a 3‐year teacher education period. The target group consisted of pre‐service teachers (N = 148) from three Finnish universities. Results indicate a growth in confidence related to all TPACK areas during the research period. The strongest gains were in pedagogical content knowledge. In addition, the gains were larger in other areas related to pedagogical knowledge than areas related to technology or content knowledge. In areas…
Il prisma del crimine di Henry e Lanier
2021
Al fine di esemplificare la tensione verso modelli integrati, il lavoro di Stuart Henry e Mark M. Lanier: Essential Criminology (2009) permette di valutare le opportunità che derivano dall’uso di un modello euristico che integra le diverse dimensioni che determinano il crimine. In order to exemplify the tension towards integrated models, the work of Stuart Henry and Mark M.: Lanier Essential Criminology (2009) allows us to evaluate the opportunities that arise from the use of a heuristic model that integrates the different dimensions that determine crime.
Ofiary działań wojennych i polegli żołnierze w Zabrzu w 1945 r
2021
¿Quién paga los platos rotos? Una exploración sobre las vícitimas de la delincuencia juvenil
2022
Se estudian los sujetos que han padecido infracciones penales atribuidas a menores de edad, a partir del análisis de los expedientes incoados a menores de edad en la provincia de Valencia durante el año 2011. Analysis of the subjects who have suffered criminal offenses attributed to minors, through the analysis of the files initiated to minors in the province of Valencia during the year 2011. Analysis of the targets who have suffered criminal offenses attributed to minors, through the analysis of the files initiated to minors in the province of Valencia during the year 2011.