Search results for "IFC"

Thioredoxin (Trxo1) interacts with proliferating cell nuclear antigen (PCNA) and its overexpression affects the growth of tobacco cell culture.

2017

Thioredoxins (Trxs), key components of cellular redox regulation, act by controlling the redox status of many target proteins, and have been shown to play an essential role in cell survival and growth. The presence of a Trx system in the nucleus has received little attention in plants, and the nuclear targets of plant Trxs have not been conclusively identified. Thus, very little is known about the function of Trxs in this cellular compartment. Previously, we studied the intracellular localization of PsTrxo1 and confirmed its presence in mitochondria and, interestingly, in the nucleus under standard growth conditions. In investigating the nuclear function of PsTrxo1 we identified proliferati…

The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor

2021

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-stress-regulated protein exhibiting cytoprotective properties through a poorly understood mechanism in various in vitro and in vivo models of neuronal and non-neuronal damage. Although initially characterized as a secreted neurotrophic factor for midbrain dopamine neurons, MANF has recently gained more interest for its intracellular role in regulating the ER homeostasis, including serving as a cofactor of the chaperone glucose-regulated protein 78 (GRP78). We aimed for a better understanding of the neuroprotective mechanisms of MANF. Here we show for the first time that MANF promotes the survival of …

Structural Health Monitoring Procedure for Composite Structures through the use of Artifcial Neural Networks

2015

In this paper different architectures of Artifcial Neural Networks (ANNs) for structural damage detection are studied. The main objective is to investigate an ANN able to detect and localize damage without any prior knowledge on its characteristics so as to serve as a real-time data processor for Structural Health Monitoring (SHM) systems. Two different architectures are studied: the standard feed-forward Multi Layer Perceptron (MLP) and the Radial Basis Function (RBF) ANNs. The training data are given, in terms of a Damage Index =D, properly defined using a piezoelectric sensor signal output to obtain suitable information on the damage position and dimensions. The electromechanical respons…

RDF2NμSMV: Mapping Semantic Graphs to NμSMV Model Checker

2011

International audience; The most frequently used language to represent the semantic graphs is the RDF (W3C standard for meta-modeling). The construction of semantic graphs is a source of numerous errors of interpretation. The processing of large semantic graphs is a limit to the use of semantics in current information systems. The work presented in this paper is part of a new research at the border between two areas: the Semantic Web and the model checking. For this, we developed a tool, RDF2NμSMV, which converts RDF graphs into NμSMV language. This conversion aims checking the semantic graphs with the model checker NμSMV in order to verify the consistency of the data. To illustrate our pro…

Development of a performance threshold approach for identifying the management options for stabilisation/solidification of lead polluted soils

2014

Two soils spiked with lead at different rates were stabilised/solidified using Portland cement and fy ash at different soil:binder ratios, and tested for their setting time, unconfined compressive strength, leachability and durability. A performance threshold approach was used in order to identify optimal management options for the products of the S/S treatment. Results show that soil texture, percentage of binders and lead concentration play an important part in the treatment, significantly influencing the performance of the resulting products in terms of curing, compressive strength and durability. Pb soil concentrations higher than 15000 mg kg-1 were found to heavily reduce the applicab…

Querying and reasoning over large scale building data sets

2016

International audience; The architectural design and construction domains work on a daily basis with massive amounts of data. Properly managing, exchanging and exploiting these data is an ever ongoing challenge in this domain. This has resulted in large semantic RDF graphs that are to be combined with a significant number of other data sets (building product catalogues, regulation data, geometric point cloud data, simulation data, sensor data), thus making an already huge dataset even larger. Making these big data available at high performance rates and speeds and into the correct (intuitive) formats is therefore an incredibly high challenge in this domain. Yet, hardly any benchmark is avai…

Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo

2015

Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis. In contrast, our knowledge of their specific molecular modes of action is limited to the interaction with few cofactors. Here, we show that Hox proteins are able to interact with a wide range of transcription factors in the live Drosophila embryo. In this context, specificity relies on a versatile usage of conserved short linear motifs (SLiMs), which, surprisingly, often restrains the interaction potential of Hox proteins. This novel buffering activity of SLiMs was observed in different tissues and found in Hox proteins from cnidarian to mouse species. Although th…

SIGA3D: Semantic Combination of IFC and GIS to support Urban Facilities Management

2011

The interoperability of Information Systems has been a research topic for over thirty years. While some forms of heterogeneity have been settled by the adoption of standards, some domains, such as the Urban Information Modeling (UIM), require specific research. The UIM combines information from the domain of Building Information Modeling (BIM) with Geographic Information System (GIS) within a collaborative platform. Using this platform, a set of heterogeneous actors takes part in the lifecycle of the urban environment through a 3D digital model. This ambition is faced with several gaps such as resolution of semantic heterogeneity in the lifecycle management system, the resolution of structu…

La Fetuina A, il gentipo AHSG e la calcificazione coronarica

HBIM data management in historical and archaeological buildings

2020

Recent technological evolutions in the acquisition and management of building data are offering new opportunities for digital reconstruction. At the same time, the BIM (Building Information Modeling) methodology, based on the implementation of libraries composed of parametric objects provided by the IFC (Industry Foundation Classes) standard, allows the design and management of data of existing buildings, and, in particular, historical and archaeological buildings. In the latter case, the great variety of Cultural Heritage (CH) distributed over the European territory, and the ability of BIM to cover the life of buildings or/and other artefacts from a geometric, descriptive, physical and sta…