Search results for "IFT"
showing 10 items of 2193 documents
Novel insulin receptor substrate 1 and 2 variants in breast and colorectal cancer
2013
The insulin/insulin-like growth factor pathway is involved in breast and colorectal cancer (CRC) development. In the present study, we analyzed the coding region and short intron-exon borders of the insulin receptor substrate 1 and 2 (IRS‑1 and IRS‑2) genes in 12 cell lines derived from breast cancer (BC), 14 cell lines derived from CRC and 33 primary CRCs. The nucleotide variants identified in BC were 3 in IRS‑1, 1 of which (p.Arg267Cys) was novel and with a pathogenic potential as predicted by in silico analysis and 6 in IRS‑2. Twenty‑one variants in IRS‑1 and 18 in IRS‑2 were identified in the CRC samples. These included 11 novel IRS‑1 variants detected exclusively in CRCs, which include…
Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells.
2011
Breast cancer is the most common cancer and the second leading cause of cancer death in industrialized countries. Systemic treatment of breast cancer is effective at the beginning of therapy. However, after a variable period of time, progression occurs due to therapy resistance. Artesunate, clinically used as anti-malarial agent, has recently revealed remarkable anti-tumor activity offering a role as novel candidate for cancer chemotherapy. We analyzed the anti-tumor effects of artesunate in metastasizing breast carcinoma in vitro and in vivo. Unlike as expected, artesunate induced resistance in highly metastatic human breast cancer cells MDA-MB-231. Likewise acquired resistance led to abol…
Acetaldehyde as a drug of abuse: insight into AM281 administration on operant-conflict paradigm in rats
2013
Increasing evidence focuses on acetaldehyde (ACD) as the mediator of the rewarding and motivational properties of ethanol. Indeed, ACD stimulates dopamine release in the nucleus accumbens and it is self-administered under different conditions. Besides the dopaminergic transmission, the endocannabinoid system has been reported to play an important role in ethanol central effects, modulating primary alcohol rewarding effect, drug-seeking and relapse behaviour. Drug motivational properties are highlighted in operant paradigms which include response-contingent punishment, a behavioural equivalent of compulsive drug use despite adverse consequences. The aim of this study was thus to characterize…
Power-Line Communication in Medium-Voltage System: Simulation Model and Onfield Experimental Tests
2012
The aim of this paper is to develop a complete model of a power-line communication (PLC) system operating on a medium-voltage (MV) network. The core-shield configuration was chosen for signal transmission in the power cables. In order to validate the developed model experimental, the medium-voltage network of the Favignana island was used to carry out detailed testing. The transmission was performed between two transformer substations in the presence of mains voltage (i.e., 24 kV). ST7540 FSK power-line transceivers, together with capacitive coupling interfaces, were used for the transmission and the reception of the communication signal. The correlation between the experimental measurement…
Substituent effect of nitro group on aromaticity of carbazole rings
2014
The molecular geometries of carbazole and its 17 nitro derivatives were optimized at the B3LYP/6-311++G(2d,2p) level of theory. The harmonic oscillator model of aromaticity and nucleus-independent chemical shift descriptors of π-electron delocalization were calculated to estimate the aromaticity of the carbazole five- and six-membered rings. The biggest changes in the value of both descriptors were observed for the pyrrole ring. The nitro group attached to 3 and/or 6 positions of the carbazole ring system exerts only a slight influence on the benzene ring aromaticity.
1H, 13C and 15N NMR spectral characterization of twenty-seven 1,2-diaryl-(4E)-arylidene-2-imidazolin-5-ones.
2006
1H, 13C and 15N NMR chemical shifts and couplings nJ(H,C) in DMSO-d6 at 30 °C have been determined for 1,2-diaryl-(4E)-arylidene-2-imidazolin-5-one derivatives 1–27. Their chemical shift assignments are based on PFG DQF 1H,1H COSY, PFG 1H,13C HMQC as well as PFG 1H,13C and 1H,15N HMBC experiments. For compounds 1–10 including aryl fluorine substituent(s) also the couplings nJ(F,C) (n = 1 − 4) are reported. Copyright © 2006 John Wiley & Sons, Ltd.
Complete 1H and 13C NMR assignments of clerodane diterpenoids of Salvia splendens.
2006
Unambiguous and complete assignments of 1H and 13C NMR chemical shifts for five clerodane diterpenes, four of them isolated from Salvia splendens (salviarin, splendidin and splenolides A and B) and one obtained by acetylation of splenolide A, are presented. The assignments are based on 2D shift-correlated [1H,1H–COSY, 1H,13C-gHSQC–1J(C,H) and 1H,13C-gHMBC-nJ(C,H) (n = 2 and 3)] and nuclear Overhauser effect (NOE) experiments. The conformation of the rings of these compounds is supported by the 3J(H,H) values and NOE results. Copyright © 2006 John Wiley & Sons, Ltd.
Effect of electron-withdrawing substituents on the electrophilicity of carbonyl carbons
2005
Indexación: Scopus The substituent effects on the carbonyl carbon atom for a series of twelve substituted phenyl acetates have been rationalized using a global electrophilicity index. This index is linearly correlated with the experimental reaction rate coefficients. We found that, in contrast to the proposed interpretation based on experimental 13C NMR chemical shifts and ground state destabilization calculations, the electrophilicity of carbonyl compounds increases due to the effect promoted by electron-withdrawing groups in these systems. https://www.sciencedirect.com/science/article/pii/S0040402004018046?via%3Dihub
Über gemischte gruppe 14-gruppe 14-bindungen
1993
Abstract The lead-tin compounds o-Tol6PbSn, o-Tol3PbSnPh3 and Mes3PbSnPh3 have been synthesized from Li and halide precursors in THF/ether at low temperatures. The crystal structures of the S4 symmetric o-Tol4Pb and of the three isomorphous title compounds have been determined (d(SnSn) 2.883 (1), d (PbSn) 2.845 (2), d (PbPb) 2.895 (2), A). The long SnSn distance is in accordance with the Raman data for the pairs of p-Tol6/o-Tol6 substituents (ν(SnSn) 131/123, ν(PbSn) 114/114, ν(PbPb) 105/103 cm−1). The sequence of the 119Sn and 207Pb chemical shifts shows clearly a polarity Pbδ−Snδ+ for all lead-tin compounds investigated. The 1J (119Sn207Pb) and 1J(119Sn119Sn) couplings of identi…
Halogen effect on structure and 13 C NMR chemical shift of 3,6-disubstituted-N -alkyl carbazoles
2013
Structures of selected 3,6-dihalogeno-N-alkyl carbazole derivatives were calculated at the B3LYP/6-311++G(3df,2pd) level of theory, and their 13C nuclear magnetic resonance (NMR) isotropic shieldings were predicted using density functional theory (DFT). The model compounds contained 9H, N-methyl and N-ethyl derivatives. The relativistic effect of Br and I atoms on nuclear shieldings was modeled using the spin–orbit zeroth-order regular approximation (ZORA) method. Significant heavy atom shielding effects for the carbon atom directly bonded with Br and I were observed (~−10 and ~−30 ppm while the other carbon shifts were practically unaffected). The decreasing electronegativity of the haloge…