Search results for "IMPACT"
showing 10 items of 1703 documents
Letter to the Editor regarding the paper by Aurilio et al., A meta-analysis of oestrogen receptor, progesterone receptor and human epidermal growth f…
2014
Sir,We have read with great interest the article in press ofAurilio et al., A meta-analysis of oestrogen receptor, pro-gesterone receptor and human epidermal growth factorreceptor 2 discordance between primary breast cancerand metastases (http://dx.doi.org/10.1016/j.ejca.2003.10.004), which will appear in Eur J Cancer. In the paper,the Authors have performed a meta-analysis of the stud-ies published in the literature concerning the discor-dance rate in oestrogen receptor (ER), progesteronereceptor (PgR) and HER2 status between primarytumour and corresponding relapse. It is well known thata considerable controversy concerns the issue of hor-mone receptors (HRs) expression as well as HER2 sta…
Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer
2016
International audience; Background: To determine whether dose/volume specific endpoints (DVSE) or Area under the rectal DVH curve (rAUC) better predict acute gastrointestinal (GI) toxicity in prostate cancer patients treated with IMRT in the era of daily image guidance (IG-IMRT). Methods: A set of DVSE was recorded from V25 to V75 (increments of 5Gy) (both in % and in cc) for 180 men. The rAUC was calculated for doses ranging between 25Gy and 50Gy (rAUC(25-50)). Univariate and multivariate logistic regressions were performed to determine the relationship between DVSE or rAUC(25-50) and the appearance of any acute GI toxicity. Results: The rates of acute grade 1 (G1), G2 and G3 GI toxicities…
Tumor biology in older breast cancer patients – What is the impact on survival stratified for guideline adherence? A retrospective multi-centre cohor…
2015
Abstract Purpose The tumor biology of older breast cancer patients (oBCP) is usually less aggressive, however applied adjuvant treatment is often less potent resulting in an impaired disease free survival and overall survival in this group. This study tries to answer the following questions for the biological subtypes of oBCP (70+ y): (1) Is there a significant difference in the distribution of the biological subtypes of oBCP vs younger breast cancer patients (yBCP; 50–69 y)? (2) Which biological subtype has the highest rate of non-guideline-adherent-treatment (GL−) among oBCP? (3) Is a single GL− (i.e. radiotherapy/surgery/endocrine-therapy/chemotherapy) significantly associated with the s…
A new sustainable food delivery platform
2022
In recent years, the food delivery business has expanded with great success and during the last months, pandemic have contributed to the growth of online food delivery. Consequently, with this fast growth of the online food delivery commerce, it’s important to analyze its environmental effects. In fact, the downside is represented by the enormous volume of waste produced by this market, consisting of packaging mostly made with materials such as paper, cardboard, plastic, and aluminum; a problem which, in relation to the volume of orders and the limits of separate collection that is not always efficient, leads to a quantity of unmanaged waste. This study aims to assess the impact of urban fo…
Perceived Usefulness of e-WOM Attributes on Buyer’s Choice
2020
Online reviews are a prevalent practice in the digital space to disseminate and acquire information about products and services which has immense effects on consumers’ decision making. The study aims to measure the direct and the interaction effects of the two review attributes of online reviews: review content and review authenticity during the pre-purchase stage on subsequent purchase intention. We conduct a between-subject 2 × 2 experimental online study with 251 participants manipulating review authenticity (verified vs unverified) and review content (general vs specific). While consumers often use online reviews for choosing experiential as well as material products, the present study …
Life Cycle Assessment of organic and conventional apple supply chains in the North of Italy
2017
Abstract This paper compares the energy and environmental impacts of organic and conventional apples cultivated in the North of Italy, by applying the Life Cycle Assessment (LCA) methodology. The authors examined the supply chain of apples, including the input of raw materials and energy sources, the farming step, the post-harvest processes and the distribution of apples to the final users. The paper develops two original contributions: 1) it enhances the limited number of studies on LCA applied to apples; 2) it compares organic and conventional apples produced in lands characterized by the same climatic conditions, to evaluate which of the two products is more competitive from an energy an…
Advance booking across channels: The effects on dynamic pricing
2021
This research analyzes the effects of advance booking and channel type on hotel rates. While this relationship has been addressed in the literature, most studies take a partial approach by focusing only on one distribution channel or one destination. This study fills this gap by analyzing the price dynamics for four channels and multiple destinations. The data set consists of 39,363 bookings for 1085 hotels over 27 consecutive months. We used two-stage least squares to solve potential endogeneity issues, and the results proved that distribution channel, hotel type and hotel size have an influence on the effect of advance booking on hotel rates. Critical managerial implications are discussed…
Demonstration of polarization pulling using a fiber-optic parametric amplifier
2012
International audience; We report the observation of all-optical polarization pulling of an initially polarization-scrambled signal using parametric amplification in a highly nonlinear optical fiber. Broadband polarization pulling has been achieved both for the signal and idler waves with up to 25 dB gain using the strong polarization sensitivity of parametric amplifiers. We further derive the probability distribution function for the final polarization state, assuming a randomly polarized initial state, and we show that it agrees well with the experiments.
Multicriteria-Oriented Optimization of Building Energy Performances: The Annex 72 IEA-EBC Experience
2021
International audience; This chapter describes the research experience of the International Energy Agency-Energy in Buildings and Communities Programme Annex 72 members on the application of multi-objective optimization processes for the selection of design or retrofit actions that allow for improving different aspects (energy, environmental, economic, etc.) of buildings in a life cycle perspective. Thirteen case studies were examined focussing on methodologies, applications and results and deriving generic conclusions and guidelines for building designers and decision-makers.
Matching Economical, Energetic and Environmental Benefits: An Analysis for Hybrid CHCP-Heat Pumps Systems
2006
Abstract The optimization of design and operation of combined heat, cooling and power systems usually leads to select different plant lay-outs and size of components, depending on the adopted optimization criterion (maximum profit or energy saving or minimum environmental impact). This occurs when the current energy prices and the normative provisions supporting cogeneration are not able to coincide with the specific customer’s interest and the overall “social interest” for a reduction in energy consumption and in pollutants’ emissions. At EU level, polygeneration is considered to have a large potential for residential and commercial buildings district network, for the tertiary sector and f…