Search results for "INITIATION"
showing 10 items of 174 documents
Conscience, cognition et choix alimentaires : Regards croisés entre psychologie et sciences de l'alimentation
2017
Differential Translational Efficiency of the mRNAs Isolated from Derepressed and Glucose Repressed Saccharomyces cerevisiae
1987
Summary: Carbon catabolite derepression induced changes in the pool of yeast mRNAs translatable in a protein-synthesizing reticulocyte system. Competition experiments with globin mRNA showed that the mRNA population obtained from derepressed cells possessed a higher translational efficiency than mRNA from repressed cells. The mRNAs that could account for the high translational efficiency of the derepressed mRNA were not detected in cells growing in glucose-rich medium. Analysis of protein synthesis in the presence of 7-methylguanosine 5′-phosphate indicated that the initiation factors recognizing the 5′-terminal structure of capped messengers interacted with lower affinity with the represse…
Wybrane aspekty odpowiedzialności z tytułu zdarzeń medycznych podmiotów leczniczych prowadzących szpital
2016
Przedmiotem artykułu jest zastosowanie odpowiedzialności z tytułu zdarzeń medycznych oraz formalne wszczęcie odpowiedniego postępowania w tym zakresie. Autor zwraca szczególną uwagę na te kwestie, które powodują istotne problemy interpretacyjne, a także wymagają komentarza co do poprawności i słuszności rozwiązań przyjętych przez ustawodawcę. Omawia pojęcie „zdarzenia medycznego”, krąg podmiotów uprawnionych do wszczęcia postępowania w przedmiocie odpowiedzialności za zdarzenia medyczne oraz kwestie dotyczące złożenia wniosku do właściwej komisji i opisania jego wymogów formalnych.
Stromal Interaction Molecule 1 (STIM1) Is Involved in the Regulation of Mitochondrial Shape and Bioenergetics and Plays a Role in Oxidative Stress
2012
Calcium ions are involved in a plethora of cellular functions including cell death and mitochondrial energy metabolism. Store-operated Ca(2+) entry over the plasma membrane is activated by depletion of intracellular Ca(2+) stores and is mediated by the sensor STIM1 and the channel ORAI1. We compared cell death susceptibility to oxidative stress in STIM1 knock-out and ORAI1 knockdown mouse embryonic fibroblasts and in knock-out cells with reconstituted wild type and dominant active STIM1. We show that STIM1 and ORAI1 deficiency renders cells more susceptible to oxidative stress, which can be rescued by STIM1 and ORAI1 overexpression. STIM1 knock-out mitochondria are tubular, have a higher Ca…
eIF2α confers cellular tolerance to S. aureus α-toxin
2015
We report on the role of conserved stress-response pathways for cellular tolerance to a pore forming toxin. First, we observed that small molecular weight inhibitors including of eIF2α-phosphatase, jun-N-terminal kinase (JNK), and PI3-kinase sensitized normal mouse embryonal fibroblasts (MEFs) to the small pore forming S. aureus α-toxin. Sensitization depended on expression of mADAM10, the murine ortholog of a proposed high-affinity receptor for α-toxin in human cells. Similarly, eIF2α (S51A/S51A) MEFs, which harbor an Ala knock-in mutation at the regulated Ser51 phosphorylation site of eukaryotic translation initiation factor 2α, were hyper-sensitive to α-toxin. Inhibition of translation w…
The distributions of protein coding genes within chromatin domains in relation to human disease.
2019
Abstract Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wide interaction maps shows functional consequences that extend the initial thought of an efficient DNA packaging mechanism: gene regulation, DNA repair, chromosomal translocations and evolutionary rearrangements seem to be only the peak of the iceberg. One key concept emerging from this research is the topologically associating domains (TADs) whose functional role in gene regulation and their association with disease is not fully untangled. Resul…
¿Depende el desarrollo de la RAN de la edad de inicio de la lectoescritura?
2018
Antecedentes:La habilidad del alumno para nombrar rápidamente estímulos familiares (RAN) es un factor implicado en el rendimiento lector evaluable de forma indiscriminada a lo largo de los primeros años de escolarización. El objetivode este estudio, pues, es analizar si la adquisición de dicha habilidad depende de variables relacionadas con una iniciación temprana a la lecto-escritura o si su desarrollo se relaciona con factores de madurez cronológica. Método: Para ello se aplicó la prueba RAN a 71 niños de 6-7 años croatas (cultura en la que la iniciación a la lectura es más tardía); a 44 niños de 4-5 años españoles (equiparando los dos grupos por edad de inicio de la lecto-escritura) y a …
MYC-driven epigenetic reprogramming favors the onset of tumorigensis by inducing a stem cell-like state
2017
AbstractBreast cancer consists of highly heterogeneous tumors, whose cell of origin and driver oncogenes resulted difficult to be uniquely defined. Here we report that MYC acts as tumor reprogramming factor in mammary epithelial cells by inducing an alternative epigenetic program, which triggers loss of cell identity and activation of oncogenic pathways. Over-expression of MYC induces transcriptional repression of lineage-specifying transcription factors, causing decommissioning of luminal-specific enhancers. MYC-driven dedifferentiation supports the onset of a stem cell-like state by inducing the activation of de novo enhancers, which drive the transcriptional activation of oncogenic pathw…
Second report on chicken genes and chromosomes 2005.
2005
International audience
Insomnia in obsessive-compulsive disorder: A Swedish population-based cohort study.
2020
Abstract Background The association between specific psychiatric disorders and insomnia is well established, but the prevalence of insomnia in obsessive-compulsive disorder (OCD) is unknown. This population-based study examined the prevalence of insomnia in patients with OCD compared to unaffected individuals from the general population and to their unaffected full siblings, and evaluated the contribution of psychiatric comorbidities to this association. Methods Individuals diagnosed with OCD (31,856) were identified from a cohort of 13,017,902 individuals living in Sweden anytime during 1973 and 2013. Logistic regression analyses were used to investigate the odds of insomnia in individuals…