Search results for "INOS"
showing 10 items of 2075 documents
Estado de conservación de las tortugas marinas en España (revisión del periodo 2013-2018)
2021
[ES] El presente documento revisa la situación y aporta nuevos datos para las tortugas marinas en España durante el periodo 2013- 2018. Se revisa el estado de conservación para el periodo 2013- 2018 en cada una de las demarcaciones marítimas españolas: Levante¿Baleares y Estrecho¿Alborán para el Mediterráneo, y Noratlántica, Sudatlántica y Macaronesia en aguas del océano Atlántico. Se incluyen análisis de tendencias, las presiones y amenazas que afectan a cada especie y bibliografía actualizada. Para Caretta caretta, se recopila la información de los nidos en las costas mediterráneas españolas desde 2013 hasta 2018 y los movimientos de juveniles nacidos en España, tras su liberación.
Disruptores endocrinos utilizados en la industria textil-confección en España
2009
Artículos originales [ES] Introducción: Los disruptores endocrinos son sustancias químicas que pueden alterar el sistema hormonal. Estas sustancias se utilizan en distintos procesos de la industria del textil-confección. Objetivos: Identificar las sustancias con efectos de disrupción endocrina utilizados en la industria del textil y la confección en España para prevenir la exposición de los trabajadores a estas sustancias. Material y métodos: En el estudio participaron 65 empresas de siete comunidades autónomas, seleccionadas mediante acuerdo entre las organizaciones empresariales y sindicales del sector. Técnicos de salud laboral de las federaciones sindicales visitaron las empresas partic…
Antimicrobial Lessons From a Large Observational Cohort on Intra-abdominal Infections in Intensive Care Units
2021
Severe intra-abdominal infection commonly requires intensive care. Mortality is high and is mainly determined by disease-specific characteristics, i.e. setting of infection onset, anatomical barrier disruption, and severity of disease expression. Recent observations revealed that antimicrobial resistance appears equally common in community-acquired and late-onset hospital-acquired infection. This challenges basic principles in anti-infective therapy guidelines, including the paradigm that pathogens involved in community-acquired infection are covered by standard empiric antimicrobial regimens, and second, the concept of nosocomial acquisition as the main driver for resistance involvement. I…
Pharmacogenomic and molecular docking studies on the cytotoxicity of the natural steroid wortmannin against multidrug-resistant tumor cells
2014
Wortmannin is a cytotoxic compound derived from the endophytic fungi Fusarium oxysporum, Penicillium wortmannii and Penicillium funiculosum that occurs in many plants, including medicinal herbs. The rationale to develop novel anticancer drugs is the frequent development of tumor resistance to the existing antineoplasic agents. Therefore, it is mandatory to analyze resistance mechanisms of novel drug candidates such as wortmannin as well to bring effective drugs into the clinic that have the potential to bypass or overcome resistance to established drugs and to substantially increase life span of cancer patients. In the present project, we found that P-glycoprotein-overexpressing tumor cells…
In vitro study of N-succinyl chitosan for targeted delivery of 5-aminosalicylic acid to colon
2011
In vitro study on N-succinyl chitosan and chitosan (control) matrices for selective colon delivery of 5-aminosalicylic acid is described. Matrices containing β-cyclodextrin were also prepared. As shown by DSC analyses, the drug was successfully loaded into the matrices reaching up to 95% entrapment efficiency. Swelling and drug release were studied at pH 1.2, pH 7.4, and in a pH gradient medium to simulate the gastro-intestinal transit. Main result of this study was a higher capability of N-succinyl chitosan alone to better control drug release in the simulated gastro-intestinal transit: N-succinyl chitosan gave the lowest release in acid medium (≅15%) and the highest in alkaline environmen…
Viability of microorganisms in novel antineoplastic and antiviral drug solutions
1998
Introduction. In determining the expiration-dates of ready-to-use antineoplastic and antiviral drug solu tions, microbiological aspects must be considered. This is especially true because many antineoplastic drugs introduced into the market are already known to lack antimicrobial activity. The purpose of this study is to evaluate the growth of four different microorganisms in ready-to-use solutions of 14 differ ent novel antineoplastic and antiviral drugs. Methods. The lowest concentrations of 14 dif ferent antineoplastic and antiviral drugs prescribed in our hospital were prepared in polyvinyl chloride bags or a polyethylene container (paclitaxel) containing 0.9% sodium chloride or 5% dex…
Studio di conglomerati bituminosi con granulato di gomma proveniente da pneumatici dismessi
2002
La ricerca di conglomerati bituminosi di elevate prestazioni sovente si associa allo studio delle implicazioni ambientali che la produzione, la posa in opera e l’esercizio di tali materiali comportano. Un aspetto assai importante, in tal senso, è l’opportunità che alcune modalità produttive offrono in termini di un ridotto consumo di inerti e del contestuale impiego di materiali destinati a discarica che, invece, vengono inseriti in processi di riciclaggio. È questo il caso della gomma proveniente dal riciclaggio industriale di pneumatici dismessi che, negli Stati Uniti ed in Canada, è divenuta una fonte sostanziosa per la realizzazione di conglomerati bituminosi. La presente ricerca, dopo …
Akomodācijas atpalikšana pirms un pēc tuvuma darba
2015
Bakalaura darbs uzrakstīts latviešu valodā, datorsalikumā uz 39 lappusēm un satur 14 attēlus, 2 tabulas, un tajā ir izmantots 30 literatūras avoti. Darba mērķis: Darba mērķis ir noskaidrot, kā akomodācijas atpalikšanu ietekmē tuvuma darbs pie datora monitora un cik ātri normalizējas šī akomodācijas atpalikšana, izmantojot modificēto retinoskopijas metodi. Metode: ar modificētās dinamiskās retinoskopijas Nott metodi tika novērtēta akomodācijas atpalikšana un tās izmaiņas eksperimenta dalībniekiem 2 stundu gara tuvuma darba laikā pie datora monitoriem un tika mērīts laiks, cik ātri akomodācijas atpalikšanas vērtība normalizēsies pēc tuvuma darba. Rezultāti un secinājumi: Akomodācijas atpalikš…
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate.
2007
Phosphatidylinositol 4,5-bisphosphate [PI(4,5) P 2 ], a phosphoinositide concentrated predominantly in the plasma membrane, binds endocytic clathrin adaptors, many of their accessory factors, and a variety of actin-regulatory proteins. Here we have used fluorescent fusion proteins and total internal reflection fluorescence microscopy to investigate the effect of acute PI(4,5) P 2 breakdown on the dynamics of endocytic clathrin-coated pit components and of the actin regulatory complex, Arp2/3. PI(4,5) P 2 breakdown was achieved by the inducible recruitment to the plasma membrane of an inositol 5-phosphatase module through the rapamycin/FRB/FKBP system or by treatment with ionomycin. PI(4,5)…
Determinants affecting consumers' attention to fish eco-labels in purchase decisions: a cross-country study
2022
PurposeThe purpose of this study was to investigate the role of consumer altruism and other socio-cultural factors in predicting how much attention consumers pay to seafood eco-labels.Design/methodology/approachThe empirical investigation was carried out by administering an online questionnaire to a sample of Italian and Spanish people from December 2019 to April 2020. After carrying out the principal component analysis procedure, the work made use of an ordinal logistic regression.FindingsBoth Italian and Spanish consumers with an altruistic attitude, who feel that food produced in a sustainable way can protect the environment and workers, appear more likely to take an eco-label into accou…