Search results for "INSPIRE"
showing 10 items of 52 documents
Closed-Loop Automatic Oxygen Control (CLAC) in Preterm Infants: A Randomized Controlled Trial
2014
BACKGROUND AND OBJECTIVE: In preterm infants receiving supplemental oxygen, routine manual control (RMC) of the fraction of inspired oxygen (FIO2) is often difficult and time consuming. We developed a system for closed-loop automatic control (CLAC) of the FIO2 and demonstrated its short-term safety and efficacy in a single-center study. The objective of this study was to test the hypothesis that this system is more effective than RMC alone in maintaining arterial oxygen saturation within target levels when evaluated over 24 hours under routine conditions and with different target levels. METHODS: We performed a multicenter, randomized controlled, crossover clinical trial in 34 preterm infa…
Engineering the crack path in lattice cellular materials through bio-inspired micro-structural alterations
2019
Abstract A computational study on the fracture behaviour of bio-inspired finite-size lattice configurations is performed in this work. The study draws inspiration from recent investigations aimed at increasing the fracture energy of some materials through small modifications of their microstructure. The main question here is whether it is possible, to some extent, to engineer the crack path in metallic cellular materials through such small micro-structural modifications and how to quantify the effect of alternative strategies. Nature provides several examples of strategies used to delay or arrest damage and crack propagation. One striking example is given by the micro-architecture of severa…
New Mussel Inspired Polydopamine-Like Silica-Based Material for Dye Adsorption
2020
A straightforward and economic procedure has been developed for the synthesis of a new polydopamine-like silica-based material that has been obtained by oxidation of catechol with KIO4 followed by reaction with 3-aminopropyltrimethoxysilane. All techniques adopted for characterization showed that the obtained material is rich in different functional groups and the morphological analyses revealed dimensions in the nanometric range. The hybrid material has been characterized by several techniques showing its polydopamine-like nature, and preliminary observations for dye adsorption have been reported.
Layered Double Hydroxides in Bioinspired Nanotechnology
2020
Layered Double Hydroxides (LDHs) are a relevant class of inorganic lamellar nanomaterials that have attracted significant interest in life science-related applications, due to their highly controllable synthesis and high biocompatibility. Under a general point of view, this class of materials might have played an important role for the origin of life on planet Earth, given their ability to adsorb and concentrate life-relevant molecules in sea environments. It has been speculated that the organic–mineral interactions could have permitted to organize the adsorbed molecules, leading to an increase in their local concentration and finally to the emergence of life. Inspired by nature, material s…
The development of nature-inspired gripping system of a flat CFRP strip for stress-ribbon structural layout
2021
Abstract The elegant stress-ribbon systems are efficient in pedestrian bridges and long-span roofs. Numerous studies defined corrosion of the steel ribbons as the main drawback of these structures. Unidirectional carbon fiber-reinforced polymer (CFRP) is a promising alternative to steel because of lightweight, high strength, and excellent corrosion and fatigue resistance. However, the application of CFRP materials faced severe problems due to the construction of the anchorage joints, which must resist tremendous axial forces acting in the stress-ribbons. Conventional techniques, suitable for the typical design of the strips made from anisotropic material such as steel, are not useful for СF…
A survey on handling computationally expensive multiobjective optimization problems using surrogates: non-nature inspired methods
2015
Computationally expensive multiobjective optimization problems arise, e.g. in many engineering applications, where several conflicting objectives are to be optimized simultaneously while satisfying constraints. In many cases, the lack of explicit mathematical formulas of the objectives and constraints may necessitate conducting computationally expensive and time-consuming experiments and/or simulations. As another challenge, these problems may have either convex or nonconvex or even disconnected Pareto frontier consisting of Pareto optimal solutions. Because of the existence of many such solutions, typically, a decision maker is required to select the most preferred one. In order to deal wi…
DOTASQ as a prototype of nature-inspired G-quadruplex ligand
2011
DOTASQ (for DOTA-templated Synthetic G-quartet) is the first prototype of nature-inspired G-quadruplex ligand: its design, founded on a possible intramolecular G-quartet formation, enables it to interact with G-quadruplex DNA via an unprecedented nature-mimicking binding mode, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand).
A Multi-touch Interface for Multi-robot Path Planning and Control
2014
In the last few years, research in human-robot interaction has moved beyond the issues concerning the design of the interaction between a person and a single robot. Today many researchers have shifted their focus toward the problem of how humans can control a multi-robot team. The rising of multi-touch devices provides a new range of opportunities in this sense. Our research seeks to discover new insights and guidelines for the design of multi-touch interfaces for the control of biologically inspired multi-robot teams. We have developed an iPad touch interface that lets users exert partial control over a set of autonomous robots. The interface also serves as an experimental platform to stud…
Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial
2020
Background There is no proven specific pharmacological treatment for patients with the acute respiratory distress syndrome (ARDS). The efficacy of corticosteroids in ARDS remains controversial. We aimed to assess the effects of dexamethasone in ARDS, which might change pulmonary and systemic inflammation and result in a decrease in duration of mechanical ventilation and mortality. Methods We did a multicentre, randomised controlled trial in a network of 17 intensive care units (ICUs) in teaching hospitals across Spain in patients with established moderate-to-severe ARDS (defined by a ratio of partial pressure of arterial oxygen to the fraction of inspired oxygen of 200 mm Hg or less assesse…
Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distr…
2019
The effect of personalised mechanical ventilation on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remains uncertain and needs to be evaluated. We aimed to test whether a mechanical ventilation strategy that was personalised to individual patients' lung morphology would improve the survival of patients with ARDS when compared with standard of care.We designed a multicentre, single-blind, stratified, parallel-group, randomised controlled trial enrolling patients with moderate-to-severe ARDS in 20 university or non-university intensive care units in France. Patients older than 18 years with early ARDS for less than 12 h were randomly assigned (1:1) to either th…