Search results for "INSULATOR"

Constitutive Promoter Occupancy by the MBF-1 Activator and Chromatin Modification of the Developmental Regulated Sea Urchin α-H2A Histone Gene

2007

The tandemly repeated sea urchin alpha-histone genes are developmentally regulated. These genes are transcribed up to the early blastula stage and permanently silenced as the embryos approach gastrulation. As previously described, expression of the alpha-H2A gene depends on the binding of the MBF-1 activator to the 5' enhancer, while down-regulation relies on the functional interaction between the 3' sns 5 insulator and the GA repeats located upstream of the enhancer. As persistent MBF-1 binding and enhancer activity are detected in gastrula embryos, we have studied the molecular mechanisms that prevent the bound MBF-1 from trans-activating the H2A promoter at this stage of development. Her…

Lieb polariton topological insulators

2018

We predict that the interplay between the spin-orbit coupling, stemming from the TE-TM energy splitting, and the Zeeman effect in semiconductor microcavities supporting exci- ton-polariton quasi-particles results in the appearance of unidirectional linear topological edge states when the top microcavity mirror is patterned to form a truncated dislocated Lieb lattice of cylindrical pillars. Periodic nonlinear edge states are found to emerge from the linear ones. They are strongly localized across the interface and they are remarkably robust in comparison to their counterparts in hexagonal lattices. Such robustness makes possible the existence of nested unidirectional dark solitons that move …

Defects, Disorder, and Strong Electron Correlations in Orbital Degenerate, Doped Mott Insulators.

2015

We elucidate the effects of defect disorder and $e$-$e$ interaction on the spectral density of the defect states emerging in the Mott-Hubbard gap of doped transition-metal oxides, such as Y$_{1-x}$Ca$_{x}$VO$_{3}$. A soft gap of kinetic origin develops in the defect band and survives defect disorder for $e$-$e$ interaction strengths comparable to the defect potential and hopping integral values above a doping dependent threshold, otherwise only a pseudogap persists. These two regimes naturally emerge in the statistical distribution of gaps among different defect realizations, which turns out to be of Weibull type. Its shape parameter $k$ determines the exponent of the power-law dependence o…

Routing quantum information in spin chains

2013

Two different models for performing efficiently routing of a quantum state are presented. Both cases involve an XX spin chain working as data bus and additional spins that play the role of sender and receivers, one of which is selected to be the target of the quantum state transmission protocol via a coherent quantum coupling mechanism making use of local/global magnetic fields. Quantum routing is achieved, in the first of the models considered, by weakly coupling the sender and the receiver to the data bus. In the second model, strong magnetic fields acting on additional spins located between the sender/receiver and the data bus allow us to perform high fidelity routing.

Controlling Molecular Self-Assembly on an Insulating Surface by Rationally Designing an Efficient Anchor Functionality That Maintains Structural Flex…

2013

Molecular self-assembly on surfaces is dictated by the delicate balance between intermolecular and molecule-surface interactions. For many insulating surfaces, however, the molecule-surface interactions are weak and rather unspecific. Enhancing these interactions, on the other hand, often puts a severe limit on the achievable structural variety. To grasp the full potential of molecular self-assembly on these application-relevant substrates, therefore, requires strategies for anchoring the molecular building blocks toward the surface in a way that maintains flexibility in terms of intermolecular interaction and relative molecule orientation. Here, we report the design of a site-specific anch…

Creating stable Floquet–Weyl semimetals by laser-driving of 3D Dirac materials

2017

Nature Communications 8, 13940 (2017). doi:10.1038/ncomms13940

Front Cover: High-pressure studies of topological insulators Bi2 Se3 , Bi2 Te3 , and Sb2 Te3 (Phys. Status Solidi B 4/2013)

2013

The Sea Urchin sns5 Chromatin Insulator Improves the Likelihood of Lentiviral Vectors in Erythroid Milieu By Organizing an Independent Chromatin Doma…

2015

Abstract Retroviral vectors are currently the most suitable vehicles for therapeutic gene transfer in hematopoietic stem cells. However, these vectors are known to integrate rather randomly throughout the genome, suffering the so called chromosomal position effects (PE). Such a critical occurrence most probably depends upon the ability of heterochromatin to spread in the inserted vector sequences. Moreover, the use of transgenes imply genotoxicity effects, since the cis-regulatory sequences harbored by the vector can disturb the proper transcription of the resident genes neighboring the integration site, potentially leading to malignant transformation. Due to their enhancer blocker activity…

Normal metal - insulator - superconductor thermometers and coolers with titanium-gold bilayer as the normal metal

2018

We have fabricated superconductor - insulator - normal metal - insulator - superconductor (SINIS) tunnel junctions in which Al acts as the superconductor, AlOx is the insulator, and the normal metal consists of a thin Ti layer (5 nm) covered with a thicker Au layer (40 nm). We have characterized the junctions by measuring their current-voltage curves between 60 mK and 750 mK. For comparison, the same measurements have been performed for a SINIS junction pair whose normal metal is Cu. The Ti-Au bilayer decreases the SINIS tunneling resistance by an order of magnitude compared to junctions where Cu is used as normal metal, made with the same oxidation parameters. The Ti-Au devices are much mo…

Topological Insulators from a Chemist's Perspective

2012

Topology and chemistry are deeply entangled subjects, whichmanifests in the way chemists like to think and approachproblems. Although not at first glance, topology allows thecategorizationoffundamentalinherentpropertiesofthehugenumber of different chemical compounds, carving out theunique features of a class of materials of different complexity,a topic which Turro worked out in his treatise on geometricaland topological thinking in chemistry.