Search results for "INTEGRATION"
showing 10 items of 1465 documents
Decoupling factors on the energy–output linkage: The Spanish case
2007
The recent increase of energy intensity in Spain and the ratification of the Kyoto protocol call for the implementation of energy policies in Spain. In this paper, we investigate the relationship between Gross Domestic Product (GDP) and Energy Consumption (EC) by taking into account several decoupling factors that can affect this linkage. Specifically, we have considered the temporal aggregation of data and its seasonal adjustments, the multivariate methodology, the substitution between EC and other inputs and the technological changes. Empirical tests reveal a long-run relationship between EC and GDP that can only be established in a complete way with a multivariate cointegration analysis.…
Dendritic Ih selectively blocks temporal summation of unsynchronized distal inputs in CA1 pyramidal neurons.
2004
The active dendritic conductances shape the input-output properties of many principal neurons in different brain regions, and the various ways in which they regulate neuronal excitability need to be investigated to better understand their functional consequences. Using a realistic model of a hippocampal CA1 pyramidal neuron, we show a major role for the hyperpolarization-activated current, I-h, in regulating the spike probability of a neuron when independent synaptic inputs are activated with different degrees of synchronization and at different distances from the soma. The results allowed us to make the experimentally testable prediction that the I-h in these neurons is needed to reduce ne…
Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition
2020
Abstract The interaction of menin (MEN1) and MLL (MLL1, KMT2A) is a dependency and provides a potential opportunity for treatment of NPM1-mutant (NPM1mut) and MLL-rearranged (MLL-r) leukemias. Concomitant activating driver mutations in the gene encoding the tyrosine kinase FLT3 occur in both leukemias and are particularly common in the NPM1mut subtype. In this study, transcriptional profiling after pharmacological inhibition of the menin-MLL complex revealed specific changes in gene expression, with downregulation of the MEIS1 transcription factor and its transcriptional target gene FLT3 being the most pronounced. Combining menin-MLL inhibition with specific small-molecule kinase inhibitors…
Multiparticle emission in the decay of Ar 31
2014
A multihit capacity setup was used to study the decay of the dripline nucleus 31Ar, produced at the ISOLDE facility at CERN. A spectroscopic analysis of the β-delayed three-proton decay of 31Ar is presented for the first time together with a quantitative analysis of the β-delayed 2pγ decay. A new method for determination of the spin of low-lying levels in the βp daughter 30S using proton-proton angular correlations is presented and used to determine that the spin of the 5.2-MeV level is most likely 3+ with 4+ also possible. The half-life of 31Ar is found to be 15.1(3) ms. An improved analysis of the Fermi β strength including the β3p-decay mode gives a total measured branching ratio of 3.60…
Brexit: An Introduction
2020
This section examines the consequences of the United Kingdom (UK)’s decision to leave the EU. Though chapters acknowledge that most will depend on the outcome of the UK–EU negotiations as Brexit will be an unpredictable case of differentiated disintegration. This section offers contributions that aim at stimulating the debate on how Brexit might be understood and analyzed. Will Brexit cause breakdown, heading forward or merely continuous muddling through? The case of Brexit serves as a research laboratory in which we can test existing theories of European integration. Are they able to explain patterns of disintegration equally to integration, or do we need new theoretical and conceptual too…
Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb
2013
Identifying the connectome of adult-generated neurons is essential for understanding how the preexisting circuitry is refined by neurogenesis. Changes in the pattern of connectivity are likely to control the differentiation process of newly generated neurons and exert an important influence on their unique capacity to contribute to information processing. Using a monosynaptic rabies virus-based tracing technique, we studied the evolving presynaptic connectivity of adult-generated neurons in the dentate gyrus (DG) of the hippocampus and olfactory bulb (OB) during the first weeks of their life. In both neurogenic zones, adult-generated neurons first receive local connections from multiple typ…
Understanding the influence of context in technology integration from teacher educators’ perspective
2021
The perspective of teachers is important for advancing the use of technology in classrooms. A considerable number of research studies have explained context in ways that have narrowed the understanding of its impact on successful technology integration. This study employs the Technological Pedagogical and Content Knowledge (TPACK) model as a lens in understanding factors influencing teachers’ integration of technology in classrooms. Data were collected using focused interviews of 19 teacher educators of three colleges of education from the southern part of Nigeria. The results reveal that among the level contexts, the meso level presented the most challenges to teachers’ efforts at integrat…
Analysis of data fusion techniques for multi-microphone audio event detection in adverse environments
2017
Acoustic event detection (AED) is currently a very active research area with multiple applications in the development of smart acoustic spaces. In this context, the advances brought by Internet of Things (IoT) platforms where multiple distributed microphones are available have also contributed to this interest. In such scenarios, the use of data fusion techniques merging information from several sensors becomes an important aspect in the design of multi-microphone AED systems. In this paper, we present a preliminary analysis of several data-fusion techniques aimed at improving the recognition accuracy of an AED system by taking advantage of the diversity provided by multiple microphones in …
Is the Fisher effect non-linear? some evidence for Spain, 1963–2002
2005
In this paper the role of non-linearities in the relationship between nominal interest rates and inflation is examined, in order to shed some additional light on the mostly unfavourable evidence on the presence of a full Fisher effect. The analysis is applied to the case of Spain for the period 1963–2002, which allows previous results on the subject to be re-examined and extended. The empirical methodology makes use of recent developments on threshold cointegration, so that cointegration between a pair of variables should be expected only once a certain threshold was reached.
Language testing as part of integration policy in Norway
2016
In this paper, we present the two standardised tests of Norwegian for adult immigrants in Norway; Test i norsk – høyere nivå, developed by Norsk språktest, and Norskprøven for voksne innvandrere, developed by Skills Norway, the main focus being on Norskprøven, with which both authors are involved. We briefly introduce the tests and the assessment practice and policy in Norway, and the challenges we see for assessment policy in our country. To conclude, we express our concern towards an integration policy where more and stricter requirements are introduced, a development that we fear may lead to segregation and alienation rather than to integration. nonPeerReviewed